Claims
- 1. A pharmaceutical composition consisting essentially of, as active ingredient, a 1,4-dithiino[2,3-c]pyrrole of the formula: ##SPC8##
- wherein A is phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or 1,8-naphthyridin-2-yl, or a said radical singly substituted by halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms, cyano or nitro, and n is zero or 1, or a non-toxic pharmaceutically-acceptable acid addition salt thereof, in association with a significant amount of a pharmaceutical carrier or coating.
- 2. A composition according to claim 1 wherein, in the 1,4-dithiino[2,3-c]pyrrole, n is zero.
- 3. A composition according to claim 1, wherein in the said 1,4-dithiino[2,3-c]pyrrole, said halogen atom is chlorine, said alkyl radical is methyl, or said alkoxy radical is methoxy.
- 4. A composition according to claim 1, wherein said 1,4-dithiino[2,3-c]pyrrole is 6-(7-chloro-1,8-naphthyridin-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole or a non-toxic pharmaceutically-acceptable acid addition salt thereof.
- 5. A composition according to claim 1, wherein said 1,4-dithiino[2,3-c]pyrrole is 6-(7-chloroquinol-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole or a non-toxic pharmaceutically-acceptable acid addition salt thereof.
- 6. A composition according to claim 1, wherein said 1,4-dithiino[2,3-c]pyrrole is 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole or a non-toxic pharmaceutically-acceptable acid addition salt thereof.
- 7. A composition according to claim 1, wherein said 1,4-dithiino[2,3-c]pyrrole is 5-(4-methylpiperazin-1-yl)carbonyloxy-6(3-nitrophenyl)-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino[2,3-c]pyrrole or a non-toxic pharmaceutically-acceptable acid addition salt thereof.
- 8. A composition according to claim 1, wherein said 1,4-dithiino[2,3-c]pyrrole is 5-(4-methylpiperazin-1-yl)carbonyloxy-6-(5-methylpyrid-2-yl)-7-oxo-2,3,6,7-tetrahydro-1,4-dithiino-[2,3-c]pyrrole or a non-toxic pharmaceutically-acceptable acid addition salt thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
72.43054 |
Dec 1972 |
FR |
|
73.37402 |
Oct 1973 |
FR |
|
Parent Case Info
This is a division of application Ser. No. 421,060 filed Dec. 3, 1973.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3818011 |
Challier et al. |
Jun 1974 |
|
3847921 |
Cotrel et al. |
Nov 1974 |
|
Non-Patent Literature Citations (1)
Entry |
Zdzislaw, Kleinrock et al., Chemical Abstracts, vol. 75, p. 196, (1971). |
Divisions (1)
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Number |
Date |
Country |
Parent |
421060 |
Dec 1973 |
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