Claims
- 1. A tetracyclic taxane having the formula
- 2. The tetracyclic taxane of claim 1 wherein R2 is benzoyloxy; R4a is acetoxy; R7a is —OR28; and R28 is as defined in claim 1.
- 3. The tetracyclic taxane of claim 2 wherein R10a is a protected hydroxy; R28 is hydrogen or hydroxy protecting group; and R31 is alkyl, alkenyl or alkynyl.
- 4. The tetracyclic taxane of claim 2 wherein R10a is —OCOR29; and R29 is as defined in claim 1.
- 5. The tetracyclic taxane of claim 2 wherein R28 is hydrogen.
- 6. The tetracyclic taxane of claim 2 wherein R28 is a hydroxy protecting group.
- 7. The tetracyclic taxane of claim 1 wherein the taxane is 10-deacetyl-9β-hydroxy-9-deoxo baccatin (III).
- 8. The tetracyclic taxane of claim 1 wherein the taxane is 7,10-bis-O-triethylsilyl-10-deacetyl-9β-hydroxy-9-deoxo baccatin (III).
- 9. The tetracyclic taxane of claim 1 wherein the taxane is 9β-hydroxy-9-deoxo baccatin (III).
- 10. The tetracyclic taxane of claim 1 wherein the taxane is 7-O-triethylsilyl-9β-hydroxy-9-deoxo baccatin (III).
- 11. The tetracyclic taxane of claim 1 wherein the taxane is 7-O-triethylsilyl-9X-hydroxy-9-deoxo-13-O-trimethylsilyl baccatin (III).
- 12. The tetracyclic taxane of claim 1 wherein the taxane is 7-O-triethylsilyl-9β-acetoxy-9-deoxo-10-deacetyl-13-O-trimethylsilyl baccatin (III).
- 13. The tetracyclic taxane of claim 1 wherein the taxane is 7,10-bis-O-triethylsilyl-9β-acetoxy-9-deoxo-10-deacetyl-13-O-trimethylsilyl baccatin (III).
REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation application based on U.S. Ser. No. 10/208,418, filed Jul. 30, 2002 which is a continuation of Ser. No. 09/566,970, filed May 9, 2000, now U.S. Pat. No. 6,495,704, which is a continuation of Ser. No. 08/522,307, filed Oct. 30, 1995, now U.S. Pat. No. 6,066,747, which is a 371 of PCT/US94/02382, filed Mar. 4, 1994, which is a continuation-in-part of Ser. No. 08/026,978, filed Mar. 5, 1993, now U.S. Pat. No. 5,990,325 and a continuation-in-part of Ser. No. 08/095,087, filed Jul. 20, 1993, now abandoned.
Government Interests
[0002] This invention was made with Government support under NIH Grant #CA 42031 and NIH Grant #CA 55131 awarded by the National Institutes of Health. The Government has certain rights in the invention.
Continuations (3)
|
Number |
Date |
Country |
Parent |
10208418 |
Jul 2002 |
US |
Child |
10765692 |
Jan 2004 |
US |
Parent |
09566970 |
May 2000 |
US |
Child |
10208418 |
Jul 2002 |
US |
Parent |
08522307 |
Oct 1995 |
US |
Child |
09566970 |
May 2000 |
US |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
08026978 |
Mar 1993 |
US |
Child |
08522307 |
Oct 1995 |
US |
Parent |
08095087 |
Jul 1993 |
US |
Child |
08522307 |
Oct 1995 |
US |