Claims
- 1. A compound of the structure: ##SPC17##
- and the C.sub.15 epimer thereof wherein
- Ar is biphenyl;
- R is hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- W and L are each a single bond or cis double bond;
- Z is single bond or trans double bond; with the proviso that when n is one and Z is a single bond, W is a single bond;
- M is keto, ##EQU9## N is hydrogen or .alpha.-hydroxyl; and wherein L, M and N are so selected as to complete the structure of a prostaglandin of the A, E or F series.
- 2. A compound of the structure: ##SPC18##
- wherein
- Ar is biphenyl;
- R is hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- W is a single bond or cis double bond;
- Z is a single bond or trans double bond; with the proviso that when n is one and Z is a single bond, W is a single bond.
- 3. A compound of the structure: ##SPC19##
- wherein
- Ar is biphenyl;
- R is hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- W is a single bond or cis double bond;
- and Z is a single bond or trans double bond; with the proviso that when n is one and Z is a single bond, W is a single bond.
- 4. A compound of the structure: ##SPC20##
- wherein
- Ar is biphenyl;
- R is hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- W is a single bond or cis double bond;
- and Z is a single bond or trans double bond; with the proviso that when n is one and Z is a single bond, W is a single bond.
- 5. A compound of the structure: ##SPC21##
- wherein
- Ar is biphenyl;
- R is hydrogen or lower alkyl;
- n is an integer from 1 to 5;
- W is a single bond or cis double bond;
- and Z is a single bond or trans double bond; with the proviso that when n is one and Z is a single bond, W is a single bond.
- 6. The compound of claim 1 wherein n is 1, Ar is p-biphenyl and said prostaglandin is PGE.sub.2.
- 7. The compound of claim 1 wherein n is 1, Ar is p-biphenyl and said prostaglandin is PGE.sub.1.
- 8. A compound of claim 1 wherein n = 1.
- 9. A compound of claim 1 wherein n = 2.
- 10. A compound of claim 1 wherein n = 3.
- 11. A compound of claim 1 wherein n = 4.
- 12. A compound of claim 1 wherein n = 5.
- 13. A compound of claim 1 wherein n = 1, Ar is p-biphenyl, W is a single bond and Z is a trans double bond.
- 14. A compound of claim 1 wherein W is a C.sub.15 double bond and Z is a trans double bond.
- 15. A compound of claim 1 wherein W is a C.sub.15 double bond, Z is a single bond and n is 2-5.
- 16. A compound of claim 1 wherein W is a single bond and Z is a trans double bond.
- 17. A compound of claim 1 wherein W and Z are both single bonds.
Priority Claims (1)
Number |
Date |
Country |
Kind |
485596 |
Jul 1974 |
NZ |
|
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of U.S. patent application Ser. No. 271,220 filed July 13, 1972, and now abandoned and Ser. No. 425,519 filed Dec. 17, 1973 and now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3671570 |
Bagli et al. |
Jun 1972 |
|
3678092 |
Finch |
Jul 1972 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2,154,309 |
May 1972 |
DT |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
271220 |
Jul 1972 |
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