Claims
- 1. A compound of the structure ##STR24## and its C.sub.15 epimer; wherein A is 1-adamantyl, 2-norbornyl, 2-(1,2,3,4-tetrahydronaphthyl) wherein said group is racemic or optically active, 2-indanyl or substituted 2-indanyl wherein said substituent is halo, trifluoromethyl, lower alkyl or lower alkoxy;
- R is hydrogen or lower alkyl;
- n is an integer from 0 to 5;
- W and L are each a single bond or cis double bond;
- Z is a single bond or trans double bond;
- M is keto, ##STR25## N is hydrogen or .alpha.-hydroxyl; X is ##STR26## wherein R' is hydrogen, alkyl of from 1 to 10 carbon atoms; aralkyl of from 7 to 9 carbon atoms; cycloalkyl of from 3 to 8 carbon atoms; .alpha.- or .beta.-naphthyl; 5-indanyl; phenyl or monosubstituted phenyl, wherein said substituent is halo, lower alkyl, lower alkoxy or phenyl;
- and wherein L, M and N are so selected as to complete the structure of the prostaglandin of the A, E or F series.
- 2. A compound according to claim 1 of the structure: ##STR27## and its C.sub.15 epimer.
- 3. The compound of claim 1 wherein M is ##STR28## L is a single bond, and N is .alpha.-hydroxyl.
- 4. A compound according to claim 1 of the structure: ##STR29## and its C.sub.15 epimer.
- 5. A compound according to claim 1 of the structure: ##STR30## and its C.sub.15 epimer.
- 6. A compound of claim 1 wherein n is 0.
- 7. A compound of claim 1 wherein n is 1.
- 8. A compound of claim 1 wherein n is 2.
- 9. A compound of claim 1 wherein n is 3.
- 10. A compound of claim 1 wherein n is 4.
- 11. A compound of claim 1 wherein n is 5.
- 12. A compound of claim 6 wherein said prostaglandin is of the E series.
- 13. A compound of claim 6 wherein said prostaglandin is of the F series.
- 14. A compound of claim 7 wherein said prostaglandin is of the E series.
- 15. A compound of claim 7 wherein said prostaglandin is of the F series.
- 16. A compound of claim 8 wherein said prostaglandin is of the E series.
- 17. A compound of claim 8 wherein said prostaglandin is of the F series.
- 18. A compound of claim 1 wherein A is 2-norbornyl.
- 19. A compound of claim 1 wherein A is 1-adamantyl.
- 20. A compound of claim 1 wherein A is 2-indanyl or substituted 2-indanyl wherein said substituent is halo, trifluoromethyl, lower alkyl or lower alkoxyl.
- 21. A compound of claim 20 wherein A is 2-(5,6-dimethoxy indanyl).
- 22. A compound of claim 1 wherein W is a cis double bond and Z is a trans double bond.
- 23. A compound of claim 1 wherein W is a cis double bond and Z is a single bond.
- 24. A compound of claim 1 wherein W is a single bond and Z is a trans double bond.
- 25. A compound of claim 1 wherein W is a single bond and Z is a single bond.
- 26. A compound of claim 12 wherein A is 2-indanyl and the prostaglandin is PGE.sub.2.
- 27. A compound of claim 13 wherein A is 2-indanyl and the prostaglandin is PGF.sub.2.alpha..
- 28. A compound of claim 12 wherein A is 2-(5,6,dimethoxy indanyl) and the prostaglandin is PGE.sub.2.
- 29. A compound of claim 13 wherein A is 2-(5,6,dimethoxy indanyl) and the prostaglandin is PGF.sub.2.alpha..
- 30. A compound of claim 16 wherein A is 1-adamantyl and the prostaglandins is PGE.sub.2.
- 31. A compound of claim 17 wherein A is 1-adamantyl and the prostaglandin is PGF.sub.2.alpha..
- 32. A compound of claim 26 wherein R and R' and each hydrogen.
- 33. A compound of claim 27 wherein R and R' are each hydrogen.
- 34. A compound of claim 28 wherein R and R' are each hydrogen.
- 35. A compound of claim 29 wherein R and R' are each hydrogen.
- 36. A compound of claim 31 wherein R and R' are each hydrogen.
- 37. A compound of claim 1 wherein A is 2-[1,2,3,4-tetrahydronaphthyl].
- 38. ##STR31## wherein R is hydrogen or CH.sub.3, wherein M is keto, ##STR32## wherein W is a single bond or cis double bond and Z is a single bond or trans double bond.
- 39. A compound of the formula: ##STR33## wherein R is hydrogen or alkyl of 1-10 carbon atoms, wherein M is keto, ##STR34## R.sub.2 is hydrogen or alkyl of 1-4 carbon atoms, wherein W is a single bond or a cis double bond and Z is a single bond or trans double bond, X is halo, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms or trifluoromethyl and n is 0-1.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of our copending application Ser. No. 304,750, filed Nov. 7, 1972 now abandoned.
US Referenced Citations (6)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
304750 |
Nov 1972 |
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