Claims
- 1. 5-X-7-R'-1,6-naphthyridin-2(1H)-one having the formula II ##STR7## or pharmaceutically acceptable or cationic salt thereof, where X is bromo, chloro or hydrazino and R' is hydrogen or methyl.
- 2. 5-Bromo-1,6-naphthyridin-2(1H)-one according to claim 1.
- 3. 5-Hydrazino-1,6-naphthyridin-2(1H)-one according to claim 1.
- 4. 5-Bromo-7-methyl-1,6-naphthyridin-2(1H)-one according to claim 1.
- 5. A cardiotonic composition for increasing cardiac contractility which comprises a pharmaceutically acceptable carrier and, as the active component thereof, a cardiotonically effective amount of 5-X-7-R'-1,6-naphthyridin-2(1H)-one of claim 1 or pharmaceutically acceptable acid-addition or cationic salt thereof, where X is bromo or chloro and R' is hydrogen or methyl.
- 6. A method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a cardiotonically effective amount of 5-X-7-R'-1,6-naphthyridin-2(1H)-one of claim 1 or pharmaceutically acceptable acid-addition or cationic salt thereof, where X is bromo or chloro and R' is hydrogen or methyl.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of copending applications Ser. No. 737,129, now abandoned filed May 23, 1985, and Ser. No. 816,591, filed Jan. 6, 1986, the latter a continuation-in-part of copending application Ser. No. 811,040, now abandoned filed Dec. 19, 1985, in turn, a continuation-in-part of copending application Ser. No. 765,900, now abandoned filed Aug. 14, 1985, in turn, a continuation-in-part of its copending application Ser. No. 695,603, filed Jan. 28, 1985 and now abandoned.
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Number |
Name |
Date |
Kind |
3993656 |
Rooney et al. |
Nov 1976 |
|
4038065 |
Johnson et al. |
Jul 1977 |
|
4415580 |
Lesher et al. |
Nov 1983 |
|
Non-Patent Literature Citations (2)
Entry |
Czuba et al., Pol J. Chem. 52, 2369-76 (1978). |
Paudler et al., J. Heterocyclic Chem. 2 (4), 393-8 (1965). |
Continuation in Parts (4)
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Number |
Date |
Country |
Parent |
737129 |
May 1985 |
|
Parent |
811040 |
Dec 1985 |
|
Parent |
765900 |
Aug 1985 |
|
Parent |
695603 |
Jan 1985 |
|