18 MC ANALOGS AS POTENTIAL ANTIADDICTIVE AGENTS

Information

• Research Project
• 2716718

• ApplicationId

  2716718

• Core Project Number

  R43DA012078

• Full Project Number

  1R43DA012078-01

• Serial Number

  12078

• FOA Number

• Sub Project Id

• Project Start Date

  9/1/1998 - 26 years ago

• Project End Date

  6/30/1999 - 25 years ago

• Program Officer Name

• Budget Start Date

  9/1/1998 - 26 years ago

• Budget End Date

  6/30/1999 - 25 years ago

• Fiscal Year

  1998

• Support Year

  1

• Suffix

• Award Notice Date

  8/21/1998 - 26 years ago

Organizations

• ALBANY MOLECULAR RESEARCH, INC.

The aim of this research is to discover new chemical entities that are efficacious as anti-addictive agents. We will synthesize target compounds that are structurally related to known Iboga alkaloids. This will involve chemical synthesis of novel compounds and general functional group manipulation. In Phase 1 of this proposal 5-8 analogs of the synthetic Iboga alkaloid 18-MC will be synthesized in parallel for subsequent testing in both in vitro and in vivo models of drug seeking behavior. Success in Phase 1 will set the stage for a more intensive chemistry and biology discovery program in Phase 2. PROPOSED COMMERCIAL APPLICATION: The ultimate goal of this research is to commercialize a new chemical entity which treats the addictive effects of one or more drugs of abuse, such as cocaine, amphetamine, alcohol or nicotine.

IC Name

• Activity

  R43

• Administering IC

  DA

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  279

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG3

• Study Section Name

• Organization Name

  ALBANY MOLECULAR RESEARCH, INC.

• Organization Department

• Organization DUNS

• Organization City

  ALBANY

• Organization State

  NY

• Organization Country

  UNITED STATES

• Organization Zip Code

  122125098

• Organization District

  UNITED STATES