Claims
- 1. A compound of the formula: ##STR129## or a pharmaceutically acceptable salt thereof, wherein: A is --CH.dbd.CH--, or --C.tbd.C--;
- X is H, CH.sub.3, NH.sub.2, NH(CH.sub.3).sub.2, N(CH.sub.3).sub.2, OH, OCH.sub.3 or SH;
- R.sub.2 is a hydrogen or a methyl or ethyl group;
- R.sub.3 is a hydrogen or a methyl or ethyl group;
- n is 0, 1, 2, 3, 4, 5, or 6; and
- R.sub.1 is selected from the group consisting of (a) C.sub.1 to C.sub.4 alky; (b) C.sub.3 to C.sub.8 cycloalkyl; (c) phenyl or substituted phenyl wherein the substituent may be an alkyl, halogen, amino, methoxy or cyano group; (d) decahydronapthalene; and (e) octahydroindene.
- 2. A compound or pharmaceutically acceptable salt thereof, as defined by claim 1, selected from the group consisting of: ##STR130##
- 3. A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein:
- A is --CH.dbd.CH--, or --C.tbd.C--;
- X is H, CH.sub.3, NH.sub.2, NH(CH.sub.3).sub.2, N(CH.sub.3).sub.2, OH, OCH.sub.3 or SH;
- R.sub.2 is a hydrogen or a methyl or ethyl group;
- R.sub.3 is a hydrogen or a methyl or ethyl group;
- n is 0, 1, 2, 3, 4, 5, or 6; and
- R.sub.1 is selected from the group consisting of (a) C.sub.1 to C.sub.4 alkyl; (b) C.sub.3 to C.sub.8 cycloalkyl; (c) phenyl or substituted phenyl wherein the substituent may be an alkyl, halogen, amino, methoxy or cyano group; (d) decahydronapthalene; and (e) octahydroindene.
- 4. A compound of the formula: ##STR131## or a pharmaceutically acceptable salt thereof, wherein: A is --CH.dbd.CH--, or
- X is H, CH.sub.3, or NH.sub.2 ;
- R.sub.2 and R.sub.3 are H;
- n is 0, 1, 2, 3, 4, or 5; and
- R.sub.1 is selected from the group consisting of (a) C.sub.1 to C.sub.4 alkyl; (b) C.sub.3 to C.sub.8 cycloalkyl; (c) phenyl or substituted phenyl wherein the substituent may be an alky, halogen, amino, methoxy or cyano group; (d) decahydronapthalene; and (e) octahydroindene.
- 5. A compound of the formula: ##STR132## where A is --CH.dbd.CH--, or
- X is H or NH.sub.2 ;
- R.sub.2 and R.sub.3 are H;
- n is 1, 2 or 3; and
- R.sub.1 is selected from the group consisting of (a) C.sub.1 to C.sub.4 alkyl; (b) C.sub.3 to C.sub.8 cycloalkyl; (c) phenyl or substituted phenyl wherein the substituent may be an alkyl, halogen, amino, methoxy or cyano group.
- 6. A compound as claimed in claim 4 having the formula: ##STR133## where R.sub.1, R.sub.2 R.sub.3, n and X are as defined in claim 4.
- 7. A compound as claimed in claim 4 having the formula: ##STR134## where R.sub.1, R.sub.2 R.sub.3, n and X are as defined in claim 4.
- 8. A compound selected from the group consisting of ##STR135## 4-(6-cyclohexyhex-cis-3-enyl)imidazole ##STR136## 4-(6-cyclohexyhex-trans-3-enyl)imidazole ##STR137## 1-cyclohexyl-6-imidazol-4-ylhex-trans-3-en-2-(S)-ylamine ##STR138## 4-(7-methyloct-3-ynyl)imidazole ##STR139## 4-(6-cyclopentylhex-3-ynyl)imidazole ##STR140## 4-(.sup.8 -phenyloct-3-ynyl)imidazole ##STR141## 4-(7,7-dimethyloct-3-ynyl)imidazole ##STR142## 4-non-3-ynylimidazole ##STR143## 4-undec-3-ynylimidpzole ##STR144## 4-(7-cyclohexylhept-3-ynyl)imidazole ##STR145## 4-(7-phenylhept-3-ynyl)imidazole ##STR146## 4-oct-3-ynylimidazole ##STR147## 4-(6-phenylhex-cis-3-enyl)imidazole ##STR148## 1-cyclohexyl-6-imidazol-4-ylhex-cis-3-en-2-(S)-ylamine ##STR149## or 1-cyclohexyl-6-imidazol-4-ylhex-.sup.3 -yn-2-(S)-ylamine ##STR150##
- 9. A compound having the structure: or a pharmaceutically acceptable salt thereof.
- 10. A compound having the structure: ##STR151## or a pharmaceutically acceptable salt thereof.
- 11. A compound having the structure: ##STR152## or a pharmaceutically acceptable salt thereof.
- 12. A compound having the structure: ##STR153## or a pharmaceutically acceptable salt thereof.
- 13. A compound having the structure: ##STR154## or a pharmaceutically acceptable salt thereof.
- 14. A compound having the structure: ##STR155## or a pharmaceutically acceptable salt thereof.
- 15. A compound having the structure: ##STR156## or a pharmaceutically acceptable salt thereof.
- 16. A compound having the structure: ##STR157## or a pharmaceutically acceptable salt thereof.
- 17. A compound having the structure: ##STR158## or a pharmaceutically acceptable salt thereof.
- 18. A compound having the structure: ##STR159## or a pharmaceutically acceptable salt thereof.
- 19. A compound having the structure: ##STR160## or a pharmaceutically acceptable salt thereof.
- 20. A compound having the structure: ##STR161## or a pharmaceutically acceptable salt thereof.
- 21. A compound having the structure: ##STR162## or a pharmaceutically acceptable salt thereof.
- 22. A compound having the structure: ##STR163## or a pharmaceutically acceptable salt thereof.
- 23. A compound having the structure: ##STR164## or a pharmaceutically acceptable salt thereof.
- 24. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of patent application U.S. Ser. No. 08/913,091 filed Sep. 5, 1997, (the U.S. national phase application of PCT application PCT/US96/07873, filed May 29, 1996, which is a continuation-in-part of U.S. Ser. No. 08/454,522, filed May 30, 1995, now abandoned.
US Referenced Citations (9)
Foreign Referenced Citations (3)
Number |
Date |
Country |
WO 9215567 |
Sep 1992 |
WOX |
WO 9314070 |
Jun 1993 |
WOX |
WO 9512581 |
May 1995 |
WOX |
Non-Patent Literature Citations (4)
Entry |
(Schwartz, 1975) Life Sci. 1.7: 503-518. |
(Inagaki et al., 1988) J. Comp. Neurol. 273: 283-300. |
(Schwartz et al., 1986) TIPS 8: 24-28. |
Babizhayel et al., "Pseudodipeptide product, etc.", CA 123:286746 (1995). |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
913091 |
|
|