Claims
- 1. A pharmaceutical composition comprising, in admixture with a pharmaceutically acceptable carrier, an anthelmintically effective amount per unit dosage of a compound of the formula ##STR5## wherein R is phenyl mono-substituted in the o-position by fluorine or in the m- or p-position by fluorine, chlorine, nitro, hydroxy, amino, formylamino, acetylamino, pentanoylamino, hexanoylamino, octanoylamino, oleoylamino, methoxyacetylamino, methylamino, dimethylamino or allylamino, or a physiologically acceptable acid addition salt thereof.
- 2. A composition of claim 1 wherein the compound is, 2-(2-fluorobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 3. A composition of claim 1 wherein the compound is, 2-(3-fluorobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 4. A composition of claim 1 wherein the compound is, 2-(4-fluorobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 5. A composition of claim 1 wherein the compound is, 2-(3-aminobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 6. A composition of claim 1 wherein the compound is, 2-(4-aminobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 7. A composition of claim 1 wherein the compound is, 2-(3-formamidobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 8. A composition of claim 1 wherein the compound is, 2-(4-formamidobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 9. A composition of claim 1 wherein the compound is, 2-(4-nitrobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazinl[2,1-a]isoquinoline.
- 10. A method of treating cestode and trematode infestations which comprises administering to an animal infested with cestodes or trematodes an anthelmintically effective amount of a compound of the formula ##STR6## wherein R is phenyl mono-substituted in the o-position by fluorine or in the m- or p-position by fluorine, chlorine, nitro, hydroxy, amino, formylamino, acetylamino, pentanoylamino, hexanoylamino, octanoylamino, oleoylamino, methoxyacetylamino, methylamino, dimethylamino or allylamino, or a physiologically acceptable acid addition salt thereof.
- 11. A composition of claim 1 wherein the compound is, 2-(4-methylaminobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 12. A composition of claim 1 wherein the compound is, 2-(4-dimethylaminobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 13. A composition of claim 1 wherein the compound is, 2-(3-acetamidobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 14. A composition of claim 1 wherein the compound is, 2-(4-acetamidobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 15. A composition of claim 1 wherein the compound is, 2-(3-methoxyacetamidobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
- 16. A composition of claim 1 wherein the compound is, 2-(4-methoxyacetamidobenzoyl)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2362539 |
Dec 1973 |
DEX |
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Parent Case Info
This is a division of application Ser. No. 533,467, filed Dec. 16, 1974, now U.S. Pat. No. 4,001,211.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4001411 |
Seubert et al. |
Jan 1977 |
|
4049659 |
Seubert et al. |
Sep 1977 |
|
4051243 |
Seubert et al. |
Sep 1977 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1470062 |
Nov 1968 |
DEX |
Divisions (1)
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Number |
Date |
Country |
Parent |
533467 |
Dec 1974 |
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