Claims
- 1. A method of treating metabolic disorders mediated by insulin resistance or hyperglycemia in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure whereinR1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms; m=0-10; n=1-3; and p=0-10; with the proviso that m+p is less than or equal to 15; or a pharmaceutically acceptable salt thereof.
- 2. The method according to claim 1, whereinm=1 and n=3 and p=6; m=4 and n=3 and p=3; m=5 and n=1 and p=6 or 8; m=7 and n=1 and p=6; or m=10 and n=1 and p=3 or a pharmaceutically acceptable salt thereof.
- 3. The method according to claim 1, wherein the compound administered isa) 2-[((Z)-1-oxo-9-octadecenyl)amino]-4-thiazoleacetic acid; b) 2-[((E)-1-oxo-9-octadecenyl)amino]-4-thiazoleacetic acid; c) 2-[(1-oxo-9-octadecynyl)amino-]4-thiazoleacetic acid; d) 2-[((Z)-1-oxo-6-octadecenyl)amino]-4-thiazoleacetic acid; e) 2-[((Z)-1-oxo-9-hexadecenyl)amino]-4-thiazoleacetic acid; f) 2-[((E)-1-oxo-9-hexadecenyl)amino]-4-thiazoleacetic acid; g) 2-[((E)-1-oxo-11-octadecenyl)amino]-4-thiazoleacetic acid; or h) 2-[((Z,Z,Z)-1-oxo-9,12,15-octadecatrienyl)amino]-4-thiazoleacetic acid or a pharmaceutically acceptable salt thereof.
- 4. A method of treating or inhibiting type II diabetes in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure whereinR1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms; m=0-10; n=1-3; and p=0-10; with the proviso that m+p is less than or equal to 15; or a pharmaceutically acceptable salt thereof.
- 5. The method according to claim 4, whereinm=1 and n=3 and p=6; m=4 and n=3 and p=3; m=5 and n=1 and p=6 or 8; m=7 and n=1 and p=6; or m=10 and n=1 and p=3 or a pharmaceutically acceptable salt thereof.
- 6. The method according to claim 4, wherein the compound administered isa) 2-[((Z)-1-oxo-9-octadecenyl)amino]-4-thiazoleacetic acid; b) 2-[((E)-1-oxo-9-octadecenyl)amino]-4-thiazoleacetic acid; c) 2-[(1-oxo-9-octadecynyl)amino]-4-thiazoleacetic acid; d) 2-[((Z)-1-oxo-6-octadecenyl)amino]-4-thiazoleacetic acid; e) 2-[((Z)-1-oxo-9-hexadecenyl)amino]-4-thiazoleacetic acid; f) 2-[((E)-1-oxo-9-hexadecenyl)amino]-4-thiazoleacetic acid; g) 2-[((E)-1-oxo-11-octadecenyl)amino]-4-thiazoleacetic acid; or h) 2-[((Z,Z,Z)-1-oxo-9,12,15-octadecatrienyl)amino]-4-thiazoleacetic acid or a pharmaceutically acceptable salt thereof.
- 7. A method of modulating glucose levels in a mammal in need thereof which comprises administering to said mammal, a compound of formula I having the structure whereinR1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms; m=0-10; n=1-3; and p=0-10; with the proviso that m+p is less than or equal to 15; or a pharmaceutically acceptable salt thereof.
- 8. The method according to claim 7, whereinm=1 and n=3 and p=6; m=4 and n=3 and p=3; m=5 and n=1 and p=6 or 8; m=7 and n=1 and p=6; or m=10 and n=1 and p=3 or a pharmaceutically acceptable salt thereof.
- 9. The method according to claim 8, wherein the compound administered isa) 2-[((Z)-1-oxo-9-octadecenyl)amino]-4-thiazoleacetic acid; b) 2-[((E)-1-oxo-9-octadecenyl)amino]-4-thiazoleacetic acid; c) 2-[(1-oxo-9-octadecynyl)amino]-4-thiazoleacetic acid; d) 2-[((Z)-1-oxo-6-octadecenyl)amino]-4-thiazoleacetic acid; e) 2-[((Z)-1-oxo-9-hexadecenyl)amino]-4-thiazoleacetic acid; f) 2-[((E)-1-oxo-9-hexadecenyl)amino]-4-thiazoleacetic acid; g) 2-[((E)-1-oxo-11-octadecenyl)amino]-4-thiazoleacetic acid; or h) 2-[((Z,Z,Z)-1-oxo-9,12,15-octadecatrienyl)amino]-4-thiazoleacetic acid or a pharmaceutically acceptable salt thereof.
Parent Case Info
This application claims the benefit of U.S. Provisional Application No. 60/112,008, which was converted from U.S. patent application Ser. No. 09/076,708, filed May 12, 1998 now abandoned, pursuant to a petition filed under 37 C.F.R. 1.53(c)(2)(i) on Jun. 16, 1998.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5688821 |
Kees |
Nov 1997 |
|
Non-Patent Literature Citations (1)
Entry |
Toth, I., Liebigs Ann. Chem., 1994, pp. 685-688. |
Provisional Applications (1)
|
Number |
Date |
Country |
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60/112008 |
May 1998 |
US |