2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents

Description

BACKGROUND OF THE INVENTION

Insect and acarid pests destroy growing and harvested crops. In the United States, agronomic crops must compete with thousands of those pests. In particular, tobacco budworms and southern armyworms are especially devastating to crops.

Tobacco budworms cause tremendous economic losses in agronomic crops. In particular, budworms devastate cotton crops by feeding on green bolls. Control of budworms is complicated by their resistance to many common insecticides, including organophosphates, carbamates and pyrethroids.

In spite of the commercial insecticides and acaricides available today, damage to crops, both growing and harvested, caused by insect and acarid pests still occurs. Accordingly, there is ongoing research to create new and more effective insecticidal and acaricidal agents.

Certain N-carbamoyl-3-carboxyaryl-heterocyclic and hydrazinecarboximidamidohydrazone compounds which are useful as herbicidal agents are described in U.S. Pat. No. 5,670,456. However, that patent does not describe any insecticidal or acaricidal activity.

Certain cyclic 1,3,4-oxadiazoline compounds are described by D. Kochetov et al in Ukrainskii Khimicheskii Zhurnal, 57(2), pp. 215-217 (1991). However, D. Kochetov et al do not disclose any utility for their cyclic 1,3,4-oxadiazoline compounds

It is, therefore, an object of the present invention to provide compounds which are useful for the control of insect and acarid pests.

It is also an object of the present invention to provide a method for the control of insect and acarid pests.

It is a further object of this invention to provide a method for the protection of growing and harvested crops from damage caused by insect and acarid attack and infestation.

These and other objects of the present invention will become more apparent from the description thereof set forth below.

SUMMARY OF THE INVENTION

The present invention comprises 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds which are useful for the control of insect and acarid pests. Those compounds are also useful for protecting plants from damage caused by insect and acarid attack and infestation.

The pesticidal 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds of the present invention have the structural formula I

wherein

X is 0 or S(O)

m

;

Z is

C(X

1

)R

5

, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl,

benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkyl-thio groups, or

phenyl optionally substituted with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups,

provided that when X is O, Z is

n and p are each independently 0, 1, 2 or 3;

X

1

is O or S;

R and R

4

are each independently halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, OR

6

, S(O)

q

R

7

, nitro, cyano, NR

8

R

9

, CO

2

R

10

, C(O)R

11

or

phenyl optionally substituted with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups, or

two adjacent R groups or R

4

groups may be taken together to form a ring wherein RR or R

4

R

4

is represented by: —OCH

2

O—, —OCF

2

O— or —CH═CH—CH═CH—;

R

6

and R

7

are each independently hydrogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl or

phenyl optionally substituted with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

4

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups;

R

8

, R

9

, R

13

and R

14

are each independently hydrogen, C

1

-C

6

alkyl, C

1

-C

6

alkylcarbonyl or

phenyl optionally substituted with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups;

R

10

and R

11

are each independently hydrogen, C

1

-C

6

alkyl or C

1

-C

6

haloalkyl;

R

1

and R

2

are each independently hydrogen, C

3

-C

7

cycloalkyl, C

1

-C

6

haloalkyl, C

3

-C

6

alkenyl, C

3

-C

6

haloalkenyl, C

3

-C

6

alkynyl, C

3

-C

6

haloalkynyl, C

2

-C

6

alkoxyalkyl, (CH

2

)

v

C(O)R

12

,

C

1

-C

6

alkyl optionally substituted with one phenoxy or phenyl group wherein the phenyl ring of each group is independently, optionally substituted with from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups,

phenyl optionally substituted with from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups, or

a 5- or 6-membered heteroaromatic ring optionally substituted with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups, and

when R

1

and R

2

are taken together with the atom to which they are attached they may form a C

3

-C

6

cycloalkyl ring wherein R

1

R

2

is represented by: —(CH

2

)

t

— where t is 2, 3, 4 or 5;

m, q and v are each independently 0, 1 or 2;

R

12

is hydrogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio, C

1

-C

6

haloalkylthio or NR

13

R

14

;

R

3

is hydrogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl or C(O)R

15

;

R

15

is C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy or C

1

-C

6

haloalkoxy; and

R

5

is C

1

-C

6

alkyl,

phenyl optionally substituted with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups, or

benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, C

1

-C

6

alkoxy, C

1

-C

6

haloalkoxy, C

1

-C

6

alkylthio or C

1

-C

6

haloalkylthio groups; and

the optical isomers thereof and the agriculturally acceptable salts thereof.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides a method for the control of insect or acarid pests which comprises contacting said pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of a 2-aryl-Δ

2

-1,3,4-(oxa or thia)diazoline compound of formula I.

The present invention also provides a method for the protection of growing plants from attack or infestation by insect or acarid pests which comprises applying to the foliage of the plants, or to the soil or water in which they are growing, a pesticidally effective amount of a 2-aryl-Δ

2

-1,3,4-(oxa or thia)diazoline compound of formula I

The pesticidal 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds of the present invention have the structural formula I

wherein n, R, R

1

, R

2

, X and Z are as described hereinabove for formula I.

Preferred 2-aryl-Δ

2

-1,3,4-oxadiazoline compounds of the present invention are those having the structural formula II

wherein

R is halogen, C

1

-C

4

haloalkyl, C

1

-C

4

haloalkoxy or

phenoxy optionally substituted with any combination of from one to three halogen, C

1

-C

4

alkyl, C

1

-C

4

haloalkyl, C

1

-C

4

alkoxy or C

1

-C

4

haloalkoxy groups;

R

4

is C

1

-C

4

haloalkyl, C

1

-C

4

haloalkoxy or C

1

-C

4

haloalkylthio;

R

1

is C

1

-C

4

alkyl;

R

2

is C

1

-C

4

alkyl, C

1

-C

4

haloalkyl, (CH

2

)

v

C(O)R

12

or

2-pyridyl optionally substituted with any combination of from one to three halogen, C

1

-C

4

alkyl, C

1

-C

4

haloalkyl, C

1

-C

4

alkoxy or C

1

-C

4

haloalkoxy groups;

v is 0 or 1;

R

12

is C

1

-C

4

alkoxy or C

1

-C

4

haloalkoxy;

R

3

is hydrogen or C(O)R

15

; and

R

15

is C

1

-C

4

alkoxy.

More preferred insecticidal and acaricidal agents of the present invention are those having the structural formula II wherein

R is F, Br, Cl or phenoxy;

R

4

is CF

3

, OCF

3

or SCF

3

;

R

1

is CH

3

;

R

2

is CH

3

, CH

2

Cl, CH

2

CF

3

, CF

3

, CH

2

CO

2

CH

3

or 2-pyridyl; and

R

3

is hydrogen or CO

2

CH

3

.

Compounds of this invention which are particularly effective insecticidal agents include

2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-bromophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-fluorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

5,5-dimethyl-2-(p-phenoxyphenyl)-4′-[(trifluoromethyl)thio]-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethoxy)-5-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

5-(chloromethyl)-2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

4,5-bis(trifluoromethyl)-2-(p-fluorophenyl)-5-methyl-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethoxy)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-bromophenyl)-5-(chloromethyl)-5-methyl-4′-(trifluoromethoxy)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethoxy)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethoxy)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide;

methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ

2

-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethoxy)-carbanilate;

methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ

2

-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethyl)-carbanilate; and

methyl 2-(p-chlorophenyl)-5-methyl-4-{[p-(trifluoromethoxy)phenyl]carbamoyl}-Δ

2

-1,3,4-oxadiazoline-5-acetate, among others.

In formula I above, 5- and 6-membered heteroaromatic rings include, but are not limited to, pyridyl, pyrazolyl, imidazolyl, triazolyl, isoxazolyl, tetrazolyl, pyrazinyl, pyridazinyl, triazinyl, furanyl, thienyl, and thiazolyl rings each optionally substituted as described in formula I above.

Exemplary of halogen hereinabove are fluorine, chlorine, bromine and iodine. The terms “C

1

-C

6

haloalkyl” , “C

1

-C

4

haloalkyl”, “C

1

-C6 haloalkoxy”, “C

1

-C

4

haloalkoxy”,

“C

1

-C

6

haloalkylthio” and “C

1

-C

4

haloalkylthio” are defined as a C

1

-C

6

alkyl group, a C

1

-C

4

alkyl group, a C

1

-C

6

alkoxy group, a C

1

-C

4

alkoxy group, a C

1

-C

6

alkylthio group and a

C

1

-C

4

alkylthio group substituted with one or more halogen atoms, respectively.

Novel 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds of the present invention are those having the structural formula I

wherein n, R, R

1

, R

2

, X and Z are as described hereinabove, provided that: (1) R is other than CO

2

R

10

when R is on the ortho-position of the phenyl ring, and (2) R

2

is other than ethyl or unsubstituted phenyl when X is O, n and p are 0 and R

1

is methyl.

Formula I compounds wherein X is O and

Z is

may be prepared, as illustrated in Flow Diagram I, by reacting a hydrazine of formula III with a ketone of formula IV in the presence of a solvent such as acetone, ethanol, methylene chloride, 1,1-diethoxyethane and the like, preferably at an elevated temperature, to form a hydrazone of formula V, and reacting the formula V hydrazone with an isocyanate or isothiocyanate of formula VI in the presence of a solvent such as 1,2-dichloroethane and ethyl acetate, preferably at an elevated temperature.

Alternatively, formula I compounds wherein X is O, R

1

is methyl, R

2

is C

1

-C

6

haloalkyl and

Z is

may be prepared, as shown in Flow Diagram II, by reacting a hydrazine of formula III with a 1-haloalkyl-1-acetoxyethylene compound of formula VII in the presence of a solvent such as ethanol, preferably at an elevated temperature, to obtain a hydrazone of formula VIII, and reacting the formula VIII hydrazone with an isocyanate or isothiocyanate of formula VI in the presence of a solvent such as 1,2-dichloroethane and ethyl acetate, preferably at an elevated temperature.

Formula I compounds wherein X is S and

Z is

may be prepared, as illustrated in Flow Diagram III, by reacting a hydrazine of formula IX with a ketone of formula IV in the presence of a solvent such as acetone, ethanol, methylene chloride, 1,1-diethoxyethane and the like to form a 2-aryl-Δ

2

-1,3,4-thiadiazoline of formula X, and reacting the formula X compound with an isocyanate or isothiocyanate of formula VI in the presence of a solvent such as 1,2-dichlorethane and ethyl acetate.

Formula I compounds wherein X is S and Z is C(X

1

)R

5

, C

1

-C

6

alkyl, C

1

-C

6

haloalkyl, optionally substituted benzyl or optionally substituted phenyl may be prepared, as illustrated in Flow Diagram IV, by reacting a 2-aryl-Δ

2

-1,3,4-thiadiazoline of formula X with a halide compound of formula XI and a base in the presence of a solvent.

In addition, certain compounds of formula I may be converted into other compounds of formula I by using conventional procedures known to those skilled in the art.

The 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds of the present invention are effective for controlling insect and acarid pests. Those compounds are also effective for protecting growing or harvested crops from damage caused by insect and acarid attack and infestation.

Insects controlled by the a 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds of this invention include Lepidoptera such as tobacco budworms, cabbage loopers, cotton boll worms, beet armyworms, southern armyworms and diamondback moths; Homoptera such as aphids, leaf hoppers, plant hoppers and white flies; Thysanoptera such as thrips; Coleoptera such as boll weevils, Colorado potato beetles, southern corn rootworms, western corn rootworms and mustard beetles; and Orthoptera such as locusts, crickets, grasshoppers and cockroaches. Acarina controlled by the compounds of this invention include mites such as two-spotted spider mites, carmine spider mites, banks grass mites, strawberry mites, citrus rust mites and leprosis mites.

In practice generally about 10 ppm to about 10,000 ppm and preferably about 100 ppm to about 5,000 ppm of a formula I compound, dispersed in water or another liquid carrier, is effective when applied to plants or the soil in which the plants are growing to protect the plants from insect and acarid attack and infestation.

The 2-aryl-Δ

2

-1,3,4-(oxa and thia)diazoline compounds of this invention are also effective for controlling insect and acarid pests when applied to the foliage of plants and/or to the soil or water in which said plants are growing in sufficient amount to provide a rate of about 0.1 kg/ha to 4.0 kg/ha of active ingredient.

While the compounds of this invention are effective for controlling insect and acarid pests when employed alone, they may also be used in combination with other biological agents, including other insecticides and acaricides. For example, the formula I compounds of this invention may be used effectively in conjunction or combination with pyrethroids, phosphates, carbamates, cyclodienes, endotoxin of

Bacillus thuringiensis

(Bt), formamidines, phenol tin compounds, chlorinated hydrocarbons, benzoylphenylureas, pyrroles and the like.

The compounds of this invention may be formulated as emulsifiable concentrates, flowable concentrates or wettable powders which are diluted with water or other suitable polar solvent, generally in situ, and then applied as a dilute spray. Said compounds may also be formulated in dry compacted granules, granular formulations, dusts, dust concentrates, suspension concentrates, microemulsions and the like all of which lend themselves to seed, soil, water and/or foliage applications to provide the requisite plant protection. Such formulations or compositions of the present invention include a compound of the invention (or combinations thereof) admixed with one or more agronomically acceptable inert, solid or liquid carriers. Those compositions contain a pesticidally effective amount of said compound or compounds, which amount may vary depending upon the particular compound, target pest, and method of use. Those skilled in the art can readily determine what is a pesticidally effective amount without undue experimentation.

In order to facilitate a further understanding of the invention, the following examples are presented primarily for the purpose of illustrating more specific details thereof. The scope of the invention should not be deemed limited by the examples, but encompasses the entire subject matter defined in the claims.

EXAMPLE 1

Preparation of 2-(α,α,α-Trifluoro-m-tolyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide

A solution of m-trifluoromethylbenzoyl hydrazine (1.84 g) and acetone (40 mL) is refluxed for 48 hours, cooled to room temperature and concentrated in vacuo to obtain a colorless hydrazone (1.48 g, m.p. 100-103° C.). A solution of the hydrazone (0.74 g), p-trifluoromethoxyphenylisocyanate (0.62 g), and 1,2-dichloroethane (15 mL) is refluxed for 16 hours, cooled to room temperature, and concentrated in vacuo to give the title product as a colorless solid (1.28 g, m.p. 120-122° C.).

Using essentially the same procedure as described for the preparation of Example 1, but using the appropriately substituted hydrazine, ketone and isocyanate, the following compounds are obtained:

Example

R

R

1

R

2

R

4

mp ° C.

2

4-Cl

CH

3

CH

3

4-OCF

3

100-105

3

4-Cl

CH

3

CH

3

4-CF

3

136-137

4

4-Cl

CH

3

CH

3

4-F

168-169

5

4-Cl

CH

3

CH

3

4-Cl

169-170

6

4-CF

3

CH

3

CH

3

4-OCF

3

121-122

7

4-CF

3

CH

3

CH

3

4-CF

3

136-137

8

3-CF

3

CH

3

CH

3

4-CF

3

156-158

9

4-Cl

CH

3

CH

3

4-SCF

3

142-143

10

4-Cl

CH

3

CH

3

4-Br

11

4-Cl

CH

3

CH

3

3-I

12

4-Cl

CH

3

CH

3

4-I

13

4-Cl

CH

3

CH

3

3-CF

3

14

4-Cl

CH

3

CH

3

4-CN

15

4-Cl

CH

3

CH

3

3-CH

3

16

4-Cl

CH

3

CH

3

4-CO

2

C

2

H

5

17

4-Cl

CH

3

CH

3

4-C

6

H

5

18

4-Cl

CH

3

CH

3

2,5-di-CH

3

19

4-Cl

CH

3

CH

3

4-CH

2

Cl

20

4-Cl

CH

3

CH

3

3,5-di-CF

3

21

4-Cl

CH

3

CH

3

2,3-(CH═CHCH═CH)

22

4-Cl

CH

3

CH

3

2,4-di-Cl

23

2,4-di-F

CH

3

CH

3

4-Cl

24

4-Cl

CH

3

CH

3

2,6-di-F

25

4-Cl

CH

3

CH

3

3-Cl-4-F

26

4-Cl

CH

3

CH

3

3,4-di-F

27

4-Br

CH

3

CH

3

4-CF

3

28

4-F

CH

3

CH

3

4-CF

3

29

4-CH

3

CH

3

CH

3

3-CF

3

30

4-OCH

3

CH

3

CH

3

4-CF

3

31

4-C

6

H

5

CH

3

CH

3

4-CF

3

32

4-OC

6

H

5

CH

3

CH

3

4-CF

3

33

4-N(CH

3

)

2

CH

3

CH

3

4-CF

3

34

4-I

CH

3

CH

3

4-CF

3

35

4-Br

CH

3

CH

3

4-OCF

3

36

4-F

CH

3

CH

3

4-OCF

3

37

4-CH

3

CH

3

CH

3

4-OCF

3

38

4-OCH

3

CH

3

CH

3

4-OCF

3

39

4-C

6

H

5

CH

3

CH

3

4-OCF

3

40

4-OC

6

H

5

CH

3

CH

3

4-OCF

3

41

4-N(CH

3

)

2

CH

3

CH

3

4-OCF

3

42

4-t-Butyl

CH

3

CH

3

4-OCF

3

43

4-I

CH

3

CH

3

4-OCF

3

44

H

CH

3

CH

3

4-CF

3

45

3,4-(CH═CHCH═CH)

CH

3

CH

3

4-CF

3

46

3,4-di-Cl

CH

3

CH

3

4-CF

3

47

4-NHC(O)CH

3

CH

3

CH

3

4-CF

3

48

2,4-di-Cl

CH

3

CH

3

4-CF

3

49

H

CH

3

CH

3

4-OCF

3

50

3,4-di-Cl

CH

3

CH

3

4-OCF

3

51

3,4-(OCH

2

O)

CH

3

CH

3

4-OCF

3

52

4-NHC(O)CH

3

CH

3

CH

3

4-OCF

3

53

4-Cl

CH

3

CH

3

4-SCF

3

54

4-Cl

CH

3

CH

3

2-Cl

55

4-Cl

CH

3

CH

3

3-SCH

3

56

4-Cl

CH

3

CH

3

2-OCF

3

57

4-Cl

CH

3

CH

3

2,4,6-tri-CH

3

58

4-Cl

CH

3

CH

3

2,4,6-tri-Cl

59

4-Br

CH

3

CH

3

4-I

60

4-F

CH

3

CH

3

4-I

61

4-CH

3

CH

3

CH

3

4-I

62

4-OCH

3

CH

3

CH

3

4-I

63

4-C

6

H

5

CH

3

CH

3

4-I

64

4-OC

6

H

5

CH

3

CH

3

4-I

65

4-N(CH

3

)

2

CH

3

CH

3

4-I

66

4-t-Butyl

CH

3

CH

3

4-I

67

4-I

CH

3

CH

3

4-I

68

4-Br

CH

3

CH

3

4-Br

69

4-F

CH

3

CH

3

4-Br

70

4-CH

3

CH

3

CH

3

4-Br

71

4-OCH

3

CH

3

CH

3

4-Br

72

4-NO

2

CH

3

CH

3

4-Br

73

4-C

6

H

5

CH

3

CH

3

4-Br

74

4-OC

6

H

5

CH

3

CH

3

4-Br

75

4-N(CH

3

)

2

CH

3

CH

3

4-Br

76

4-t-Butyl

CH

3

CH

3

4-Br

77

4-I

CH

3

CH

3

4-Br

78

4-Br

CH

3

CH

3

4-CN

79

4-F

CH

3

CH

3

4-CN

80

4-CH

3

CH

3

CH

3

4-CN

81

4-OCH

3

CH

3

CH

3

4-CN

82

4-NO

2

CH

3

CH

3

4-CN

83

4-OC

6

H

5

CH

3

CH

3

4-CN

84

4-N(CH

3

)

2

CH

3

CH

3

4-CN

85

4-I

CH

3

CH

3

4-CN

86

4-Br

CH

3

CH

3

4-SCF

3

87

4-F

CH

3

CH

3

4-SCF

3

88

4-CH

3

CH

3

CH

3

4-SCF

3

89

4-OCH

3

CH

3

CH

3

4-SCF

3

90

4-NO

2

CH

3

CH

3

4-SCF

3

91

4-C

6

H

5

CH

3

CH

3

4-SCF

3

92

4-OC

6

H

5

CH

3

CH

3

4-SCF

3

93

4-N(CH

3

)

2

CH

3

CH

3

4-SCF

3

94

4-I

CH

3

CH

3

4-SCF

3

95

4-Cl

CH

3

C

6

H

5

4-OCF

3

52-62

96

4-Cl

—(CH

2

)

4

—

4-OCF

3

138-139

97

4-Cl

CH

3

C

6

H

5

4-CF

3

123-152

98

4-Cl

CH

3

CO

2

CH

3

4-OCF

3

126-127

99

4-Cl

H

C

6

H

5

4-OCF

3

216-217

100

4-Cl

C

6

H

5

C

6

H

5

4-OCF

3

122-123

101

4-Cl

H

CH

2

C

6

H

5

4-OCF

3

106-108

102

4-Cl

H

CH

3

4-OCF

3

116-118

103

4-Cl

—(CH

2

)

3

—

4-CF

3

167-168

104

4-Cl

H

CH

3

4-CF

3

132-133

105

4-Cl

H

C

6

H

5

4-CF

3

208-210

106

4-Cl

—(CH

2

)

3

—

4-OCF

3

130-131

107

4-Cl

H

CH

2

C

6

H

5

4-CF

3

137-138

108

4-Cl

CH

3

CO

2

CH

3

4-CF

3

162-163

109

4-Cl

CH

3

C

2

H

5

4-CF

3

146-147

110

4-Cl

C

2

H

5

C

2

H

5

4-CF

3

118-119

111

4-Cl

C

2

H

5

CH

3

4-OCF

3

119-120

112

4-Cl

C

2

H

5

C

2

H

5

4-OCF

3

84-86

113

4-Cl

CH

3

3-pyridyl

4-CF

3

137-138

114

4-Cl

CH

3

3-pyridyl

4-OCF

3

66-67

115

4-Cl

CH

3

4-Cl—C

6

H

4

4-CF

3

219-220

116

4-Cl

CH

3

4-Cl—C

6

H

4

4-OCF

3

222-223

117

4-Cl

CH

3

4-CF

3

170-171

118

4-Cl

CH

3

4-OCF

3

141-142

119

4-Cl

1-indanylidene

4-CF

3

76-77

120

4-Cl

CH

3

CH

2

Cl

4-CF

3

183-184

121

4-Cl

CH

3

CH

2

Cl

4-OCF

3

166-167

122

4-Cl

CH

3

CH

2

F

4-CF

3

195-196

123

4-Cl

CH

3

CH

2

F

4-OCF

3

176-177

124

4-Cl

CH

2

Cl

CH

2

Cl

4-CF

3

197 (dec.)

125

4-Cl

CH

3

CH

2

CO

2

CH

3

4-CF

3

145-147

126

4-Cl

CH

3

CH

2

CO

2

CH

3

4-OCF

3

138-139

127

4-Cl

CH

3

CH

2

OC

6

H

5

4-CF

3

128-129

128

4-Cl

CH

3

CH

2

OC

6

H

5

4-OCF

3

100-101

129

4-F

CH

3

CH

2

Cl

4-CF

3

143-144

130

4-Br

CH

3

CH

2

Cl

4-CF

3

175-176

131

4-F

CH

3

CH

2

Cl

4-OCF

3

101-103

132

4-Br

CH

3

CH

2

Cl

4-OCF

3

155-156

133

4-Cl

CH

3

CHCl

2

4-CF

3

175-176

134

4-Cl

CH

3

CHCl

2

4-OCF

3

135-136

135

4-Cl

CH

3

CH

2

CF

3

4-CF

3

131-132

136

4-Cl

CH

3

CH

2

CF

3

4-OCF

3

106-107

137

4-Cl

CH

3

CH

2

OCH

3

4-OCF

3

112-113

138

4-Cl

CH

3

CH

2

OCH

3

4-CF

3

165-166

139

4-Cl

CH

3

CH

2

OC(O)CH

3

4-CF

3

147-148

140

4-Cl

CH

3

CH

2

OC(O)CH

3

4-OCF

3

117-118

141

4-Cl

CH

3

3-thienyl

4-OCF

3

223

142

4-Cl

CH

3

2-thiophene

4-CF

3

196

143

4-Cl

CH

3

2-furyl

4-CF

3

172

144

4-Cl

CH

3

3-thienyl

4-CF

3

201

145

4-Cl

CH

3

2-pyridyl

4-CF

3

136

146

4-Cl

CH

3

2-pyridyl

4-OCF

3

135

147

4-Br

CH

3

2-pyridyl

4-CF

3

151-153

148

4-Br

CH

3

2-pyridyl

4-OCF

3

135-136

149

4-Cl

CH

3

CH

2

C

6

H

5

4-OCF

3

125-126

150

4-Cl

CH

3

CH

2

-4-OCH

3

—

4-CF

3

145

C

6

H

4

151

4-Cl

CH

3

CH

2

-4-OCH

3

—

4-OCF

3

124

C

6

H

4

152

4-I

CH

3

2-pyridyl

4-CF

3

154

153

4-I

CH

3

2-pyridyl

4-OCF

3

151-152

154

4-Cl

CH

3

4-F—C

6

H

4

4-CF

3

202

155

4-Cl

CH

3

4-OCH

3

—C

6

H

4

4-CF

3

168-170

156

4-Cl

CH

3

CH

2

C

6

H

5

4-CF

3

130

157

4-Cl

CH

3

4-F—C

6

H

4

4-OCF

3

189-190

158

4-Cl

CH

3

4-Br—C

6

H

4

4-OCF

3

218-219

159

4-Cl

CH

3

3,4-di-F—C

6

H

3

4-OCF

3

110-111

160

4-Cl

CH

3

3,4-di-Cl—C

6

H

3

4-CF

3

220

161

4-Cl

CH

3

4-CH

3

—C

6

H

4

4-OCF

3

209

162

4-Cl

CH

3

3,4-di-F—C

6

H

3

4- CF

3

172-174

163

4-Cl

CH

3

4-Br—C

6

H

4

4-CF

3

206-207

164

4-Cl

CH

3

4-CF

3

—C

6

H

4

4-CF

3

73

165

4-Cl

CH

3

4-CF

3

—C

6

H

4

4-OCF

3

192-193

EXAMPLE 166

Preparation of 2-(p-Chlorophenyl)-5-methyl-5-trifluoromethyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-oxadiazoline-4-carboxanilide

A mixture of p-chlorobenzoyl hydrazine (1.77 g), 1-trifluoromethyl-l-acetoxyethylene (1.78 g) and ethanol (35 mL) is refluxed for 17 hours, cooled to room temperature, and concentrated in vacuo to obtain the corresponding benzoyl hydrazone (0.71 g). A mixture of the hydrazone (0.8 g) and 1,2-dichloroethane (10 mL) is treated with a p-trifluoromethylphenylisocyanate (0.67 g), heated at reflux for 87 hours, and concentrated in vacuo to obtain a colorless solid (1.48 g). Flash chromatography of the solid on silica gel (25% CH

2

Cl

2

/hexanes to 50% CH

2

Cl

2

/hexanes) gives the title product as a colorless solid (0.16 g, m.p. 157-158° C.).

Using essentially the same procedure as described for Example 166, but using the appropriately substituted hydrazine and isocyanate, the following compounds are obtained.

Example

R

R

4

mp ° C.

167

Cl

OCF

3

128-129

168

Br

CF

3

156-157

169

F

CF

3

141-142

EXAMPLE 170

Preparation of p-chlorobenzoylthiohydrazide

A solution of carbon disulfide (4.5 mL, 75 mmol) and tetrahydrofuran (50 mL) is cooled to 0° C., treated dropwise with a solution p-chlorophenylmagnesium bromide (50 mL of 1M solution) at a rate that maintains the temperature below 10° C., warmed to and stirred at room temperature for 2 hours, concentrated in vacuo and diluted with water. The resultant aqueous mixture is filtered through diatomaceous earth. The filtrate is treated with a solution of chloroacetic acid (5.67 9), sodium hydrogen carbonate (3.82 9) and water (24 mL), stirred for three days at room temperature, acidified to pH 1 with 50% aqueous sulfuric acid and filtered to obtain the thioester (8.98 g). To a cold (0° C.) solution of the thioester (3.5 g), sodium hydroxide (0.58 g) and water (35 mL) is added hydrazine hydrate (1.4 g). During the addition, the color changes from red to yellow and a solid precipitates. The solid is collected, washed with water, and dried to give the title product (1.92 g, m.p. 112-114° C.).

EXAMPLE 171

Preparation of 2-(p-chlorophenyl)-5,5-dimethyl-Δ

2

-1,3,4-thiadiazoline

A solution of p-chlorobenzoylthiohydrazine (1.02 g), acetone (1.89 g) and ethanol (5 mL) is stirred at room temperature for 4 days and the solvents are evaporated to obtain a brown solid. Flash chromatography of the brown solid on silica gel (10% ethyl acetate/hexanes) gives the title product as a yellow solid (0.44 g, m.p. 51-53° C.).

EXAMPLE 172

Preparation of 2-(p-Chlorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ

2

-1,3,4-thiadiazoline-4-carboxanilide

A solution of 2-(p-chlorophenyl)-5,5-dimethyl-Δ

2

-1,3,4-thiadiazoline (0.33 9) and 1,2-dichloroethane (8 mL) is treated with p-trifluoromethylphenylisocyanate (0.30 g), stirred for 72 hours at room temperature, and concentrated in vacuo to obtain a solid. Flash chromatography of the solid on silica gel (30% methylene chloride/hexanes) gives the title product as a colorless solid (0.61 g, m.p. 129-131° C.).

Using essentially the same procedure as described for Example 172, but using the appropriately substituted isocyanate, the following compound is obtained:

EXAMPLE 174

Preparation of 1-Oxide-2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ

2

-1,3,4-thiadiazoline-4-carboxanilide

A solution of 2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ

2

-1,3,4-thiadiazoline-4-carboxanilide (0.50 g) and dichloromethane (15 mL) is stirred at −5° C., treated with 3-chloroperoxybenzoic acid (1.79 g, 70%), stirred for 18 hours at room temperature, treated with additional 3-chloroperoxybenzoic acid (0.12 9, 70%), stirred for 14 hours at room temperature, washed with 5% sodium carbonate solution, dried over anhydrous magnesium sulfate, and concentrated in vacuo to obtain a solid. Flash chromatography of the solid on silica gel using a 10% ethyl acetate in hexanes solution gives the title product as a colorless solid (0.42 g, m.p. 181° C.).

EXAMPLE 176

Insecticidal and Acaricidal Evaluation of Test Compounds

Test solutions are prepared by dissolving the test compound in a 35% acetone in water mixture to give a concentration of 10,000 ppm. Subsequent dilutions are made with water as needed.

Spodoptera eridania

, 2nd Instar Larvae, Southern Armyworm (SAW)

A Sieva lima bean leaf expanded to 7-8 cm in length is dipped in the test solution with agitation for 3 seconds and allowed to dry in a hood. The leaf is then placed in a 100×10 mm petri dish containing a damp filter paper on the bottom and ten 2nd instar caterpillars. At 5 days, observations are made of mortality, reduced feeding, or any interference with normal molting.

Diabrotica virgifera viraifera

Leconte, 2nd Instar Western Corn Rootworm (WCR)

One cc of fine talc is placed in a 30 mL wide-mouth screw-top glass jar. One mL of the appropriate acetone test solution is pipetted onto the talc so as to provide 1.25 mg of active ingredient per jar. The jars are set under a gentle air flow until the acetone is evaporated. The dried talc is loosened, 1 cc of millet seed is added to serve as food for the insects and 25 mL of moist soil is added to each jar. The jar is capped and the contents thoroughly mixed mechanically. Following this, ten 2nd instar rootworms are added to each jar and the jars are loosely capped to allow air exchange for the larvae. The treatments are held for 5 days when mortality counts are made. Missing larvae are presumed dead, since they decompose rapidly and cannot be found. The concentrations of active ingredient used in this test correspond approximately to 50 kg/ha.

Tetranychus urticae

(OP-resistant strain), 2-Spotted Spider Mite (TSM)

Sieva lima bean plants with primary leaves expanded to 7-8 cm are selected and cut back to one plant per pot. A small piece is cut from an infested leaf taken from the main colony and placed on each leaf of the test plants. This is done about 2 hours before treatment to allow the mites to move over to the test plant to lay eggs. The size of the cut, infested leaf is varied to obtain about 100 mites per leaf. At the time of test treatment, the piece of leaf used to transfer the mites is removed and discarded. The newly-infested plants are dipped in the test solution for 3 seconds with agitation and set in the hood to dry. After 2 days, one leaf is removed and mortality counts are made.

Aphis gossypii

, Cotton Aphid (CA)

Cotton plants at the cotyledon stage are selected and cut back to one plant per pot. A heavily infested leaf is taken from the main colony and placed on top of each cotyledon. The aphids are allowed to transfer to the host plant overnight. At the time of test treatment, the leaf used to transfer the aphids is removed and discarded. The cotyledons are dipped in the test solution and allowed to dry. After 5 days, mortality counts are made.

Diabrotica undecimpunctata howardi

, Eggs-southern Corn Rootworm (SCR-Eggs)

Wells containing artificial diet are treated with the test solutions and dried. Southern corn rootworm eggs are then placed in the wells. The wells are covered with vented, adhesive, clear plastic covers. After 7 days, mortality counts are made.

Heliothis virenscens

, 3rd Instar Tobacco Budworm (TBW)

Cotton cotyledons are dipped in the test solution and allowed to dry in a hood. When dry, each is cut into quarters and ten sections are placed individually in 30 mL plastic medicine cups containing a 5 to 7 mm long piece of damp dental wick. One 3rd instar caterpillar is added to each cup and a cardboard lid placed on the cup. Treatments are maintained for 3 days before mortality counts and estimates of reduction in feeding damage are made.

The tests are rated according to the scale shown below and the data obtained are shown in Table I.

Rating Scale

0 = no effect

5 = 56-65% kill

1 = 10-25% kill

6 = 66-75% kill

2 = 26-35% kill

7 = 76-85% kill

3 = 36-45% kill

8 = 86-99% kill

4 = 46-55% kill

9 = 100% kill

TABLE I

Insecticidal and Acaricidal Evaluations

SCR

CA

SAW

TBW

TSM

Eggs

WCR

Ex.

(300

1

)

(300

1

)

(300

1

)

(300

1

)

(1000

1

)

(50

1

)

1

0

9

4

0

9

0

2

9

9

0

9

3

0

9

9

0

9

4

4

0

4

0

0

0

5

0

9

3

2

9

0

6

0

9

9

0

9

1

7

0

9

8

0

9

0

8

0

0

0

0

0

9

0

9

9

0

9

2

10

0

9

3

0

9

0

11

0

0

9

0

0

12

0

9

9

0

9

0

13

0

7

0

0

0

0

14

0

9

9

0

9

0

15

0

0

4

0

0

16

0

8

0

0

9

0

17

0

9

0

0

0

0

18

0

0

0

0

1

19

0

20

0

21

0

22

0

1

0

0

0

23

0

8

0

0

0

1

24

0

2

0

0

0

25

0

2

3

0

0

26

0

0

0

0

1

27

0

9

9

0

9

0

28

0

9

9

0

9

4

29

0

9

0

0

9

0

30

0

9

1

0

9

0

31

0

9

0

0

9

0

32

0

9

8

0

9

0

33

0

9

1

0

9

0

34

0

9

9

0

9

0

35

0

9

9

0

9

0

36

5

9

8

0

9

9

37

0

9

0

0

9

0

38

0

9

1

0

8

0

39

0

9

1

0

9

1

40

0

9

3

0

9

0

41

0

9

3

0

9

0

42

0

1

0

9

0

43

0

9

9

0

9

0

44

0

9

0

0

9

0

45

0

8

0

0

0

0

46

0

8

0

0

0

0

47

0

9

5

0

0

0

48

0

9

6

0

9

0

49

0

9

1

0

9

7

50

0

9

0

0

0

0

51

0

9

5

0

0

0

52

0

9

0

0

0

0

53

0

9

0

0

9

4

54

0

0

0

4

55

0

0

8

0

56

0

0

8

0

57

8

0

0

7

0

58

0

8

0

0

0

0

59

0

9

9

0

9

0

60

0

9

9

0

9

0

61

0

9

0

0

9

0

62

0

9

1

0

0

0

63

0

9

0

0

9

0

64

0

9

9

0

9

0

65

0

9

7

0

9

0

66

0

4

0

0

0

67

0

9

9

0

9

0

68

0

8

1

0

8

9

69

0

9

9

0

9

2

70

0

3

0

0

1

71

0

1

0

0

3

72

0

1

0

0

2

73

6

0

9

2

74

0

9

6

0

7

1

75

0

1

0

7

9

76

0

0

0

0

4

77

0

9

0

0

8

0

78

0

9

0

0

8

0

79

0

9

0

0

9

1

80

0

3

0

0

9

81

0

1

0

0

0

82

0

6

0

0

2

83

0

3

0

0

0

84

0

0

0

0

0

85

0

0

0

0

3

86

0

9

9

0

4

87

0

9

8

0

9

88

0

9

0

0

0

89

0

9

1

0

0

90

0

8

0

0

0

91

0

9

7

0

0

92

0

9

0

0

0

93

0

9

0

0

0

94

0

9

7

0

0

95

0

9

9

0

9

0

96

0

0

0

0

0

97

0

9

3

0

9

0

98

0

9

3

0

9

1

99

0

9

0

0

0

0

100

0

0

0

0

0

101

0

9

8

0

9

0

102

0

9

6

0

7

0

103

0

9

9

0

8

0

104

0

9

2

0

8

0

105

0

9

3

0

0

0

106

0

9

1

0

9

1

107

0

9

2

0

9

0

108

0

0

0

4

109

0

9

8

0

9

0

110

0

9

7

0

9

0

111

0

9

9

4

9

9

112

0

9

9

0

9

3

113

0

9

4

0

9

4

114

0

9

2

0

9

2

115

0

9

9

0

9

3

116

0

9

9

0

8

3

117

0

9

7

0

8

0

118

0

7

0

0

8

0

119

0

8

9

0

0

0

120

0

9

9

0

9

0

121

0

9

9

0

9

3

122

0

9

8

0

0

0

123

0

9

9

0

0

0

124

0

5

0

0

0

125

0

9

7

0

8

0

126

0

9

0

0

9

0

127

0

9

6

0

8

3

128

0

9

6

0

9

3

129

0

9

9

0

2

130

0

9

9

0

0

131

0

9

9

0

0

132

0

9

9

0

0

133

0

9

8

0

0

134

7

9

6

2

1

135

0

9

0

1

136

0

9

0

2

137

0

9

3

0

138

0

6

0

9

139

0

8

0

2

140

0

9

0

3

141

0

8

0

0

9

0

142

0

2

0

0

1

143

0

0

0

0

0

144

0

2

0

9

2

145

0

9

0

0

0

6

146

0

9

8

0

9

0

147

0

9

0

0

6

148

0

6

0

0

7

149

0

9

0

9

0

150

0

0

0

0

0

151

0

0

0

9

0

152

0

4

0

0

9

0

153

0

0

0

0

0

154

0

9

4

0

8

0

155

0

9

0

0

9

0

156

0

0

0

9

0

157

0

9

9

0

9

4

158

0

8

0

0

9

0

159

0

9

9

0

9

0

160

0

4

0

9

3

161

0

9

7

0

0

0

162

0

9

9

0

8

0

163

0

6

0

8

0

164

0

9

7

0

3

165

0

9

0

8

166

0

9

9

0

9

0

167

0

9

9

0

7

4

168

0

9

9

0

9

0

169

0

9

9

0

9

0

172

0

9

9

0

0

173

0

9

9

0

0

1

rates in ppm

Claims

1. A method for the control of insect or acarid pests which comprises contacting said pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of a compound having the structural formula whereinX is O or S(O)m; Z is C(X1)R5, C1-C6alkyl, C1-C6haloalkyl, benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, provided that when X is O, Z is n and p are each independently 0, 1, 2 or 3; X1 is O or S; R and R4 are each independently halogen, C1-C6alkyl, C1-C6haloalkyl, OR6, S(O)qR7, nitro, cyano, NR8R9, CO2R10, C(O)R11 or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or two adjacent R groups or R4 groups may be taken together to form a ring wherein RR or R4R4 is represented by: —OCH2O—, —OCF2O— or —CH═CH—CH═CH—; R6 and R7 are each independently hydrogen, C1-C6alkyl, C1-C6haloalkyl or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C4haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; R8, R9, R13 and R14 are each independently hydrogen, C1-C6alkyl, C1-C6alkylcarbonyl or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; R10 and R11 are each independently hydrogen, C1-C6alkyl or C1-C6haloalkyl; R1 and R2 are each independently hydrogen, C3-C7cycloalkyl, C1-C6haloalkyl, C3-C6alkenyl, C3-C6haloalkenyl, C3-C6alkynyl, C3-C6haloalkynyl, C2-C6alkoxyalkyl, (CH2)vC(O)R12, C1-C6alkyl optionally substituted with one phenoxy or phenyl group wherein the phenyl ring of each group is independently, optionally substituted with from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, phenyl optionally substituted with from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or a 5- or 6-membered heteroaromatic ring optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, and when R1 and R2 are taken together with the atom to which they are attached they may form a C3-C6cycloalkyl ring wherein R1R2 is represented by: —(CH2)t— where t is 2, 3, 4 or 5; m, q and v are each independently 0, 1 or 2; R12 is hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio, C1-C6haloalkylthio or NR13R14; R3 is hydrogen, C1-C6alkyl, C1-C6haloalkyl or C(O)R15; R15 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy or C1-C6haloalkoxy; and R5 is C1-C6alkyl, phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; and the optical isomers thereof and the agriculturally acceptable salts thereof.
2. The method according to claim 1 wherein the compound has the structural formula whereinR is halogen, C1-C4haloalkyl, C1-C4haloalkoxy or phenoxy optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; R4 is C1-C4haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio; R1 is C1-C4alkyl; R2 is C1-C4alkyl, C1-C4haloalkyl, (CH2)vC(O)R12 or 2-pyridyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; v is 0 or 1; R12 is C1-C4alkoxy or C1-C4haloalkoxy; R3 is hydrogen or C(O)R15; and R15 is C1-C4alkoxy.
3. The method according to claim 2 whereinR is F, Br, Cl or phenoxy; R4 is CF3, OCF3 or SCF3; R1 is CH3; R2 is CH3, CH2Cl, CH2CF3, CF3, CH2CO2CH3 or 2-pyridyl; and R3 is hydrogen or CO2CH3.
4. The method according to claim 1 wherein the compound is selected from the group consisting of2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-fluorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5,5-dimethyl-2-(p-phenoxyphenyl)-4′-[(trifluoromethyl)-thio]-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethoxy)-5-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 4,5-bis(trifluoromethyl)-2-(p-fluorophenyl)-5-methyl-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5-(chloromethyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethoxy)-carbanilate; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethyl)-carbanilate; and methyl 2-(p-chlorophenyl)-5-methyl-4-{[p-(trifluoromethoxy)phenyl]carbamoyl}-Δ2-1,3,4-oxadiazoline-5-acetate.
5. A method for the protection of growing plants from attack or infestation by insect or acarid pests which comprises applying to the foliage of the plants, or to the soil or water in which they are growing, a pesticidally effective amount of a compound having the structural formula wherein n, R, R1, R2, X and Z are as described in claim 1.
6. The method according to claim 5 wherein the compound has the structural formula whereinR is halogen, C1-C4haloalkyl, C1-C4haloalkoxy or phenoxy optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; R4 is C1-C4haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio; R1 is C1-C4alkyl; R2 is C1-C4alkyl, C1-C4haloalkyl, (CH2)vC(O)R12 or 2-pyridyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; v is 0 or 1; R12 is C1-C4alkoxy or C1-C4haloalkoxy; R3 is hydrogen or C(O)R15; and R15 is C1-C4alkoxy.
7. The method according to claim 6 whereinR is F, Br, Cl or phenoxy; R4 is CF3, OCF3 or SCF3; R1 is CH3; R2 is CH3, CH2Cl, CH2CF3, CF3, CH2CO2CH3 or 2-pyridyl; and R3 is hydrogen or CO2CH3.
8. The method according to claim 5 wherein the compound is selected from the group consisting of2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-fluorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5,5-dimethyl-2-(p-phenoxyphenyl)-4′-[(trifluoromethyl)-thio]-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethoxy)-5-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 4,5-bis(trifluoromethyl)-2-(p-fluorophenyl)-5-methyl-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5-(chloromethyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethoxy)-carbanilate; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethyl)-carbanilate; and methyl 2-(p-chlorophenyl)-5-methyl-4-{[p-(trifluoromethoxy)phenyl]carbamoyl}-Δ2-1,3,4-oxadiazoline-5-acetate.
9. The method according to claim 5 wherein the compound is applied to the plants, or to the soil or water in which they are growing, at a rate of about 0.1 kg/ha to 4.0 kg/ha.
10. A compound having the structural formula whereinR is halogen, C1-C4haloalkyl, C1-C4haloalkoxy or phenoxy optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; R4 is C1-C4haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio; R1 is C1-C4alkyl; R2 is C1-C4alkyl, C1-C4haloalkyl, (CH2)vC(O)R12 or 2-pyridyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; v is 0 or 1; R12 is C1-C4alkoxy or C1-C4haloalkoxy; R3 is hydrogen or C(O)R15; and R15 is C1-C4alkoxy.
11. The compound according to claim 10 whereinR is F, Br, Cl or phenoxy; R4 is CF3, OCF3 or SCF3; R1 is CH3; R2 is CH3, CH2Cl, CH2CF3, CF3, CH2CO2CH3 or 2-pyridyl; and R3 is hydrogen or CO2CH3.
12. A compound selected from the group consisting of2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-fluorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5,5-dimethyl-2-(p-phenoxyphenyl)-4′-[(trifluoromethyl)-thio]-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethoxy)-5-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 4,5-bis(trifluoromethyl)-2-(p-fluorophenyl)-5-methyl-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5-(chloromethyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethoxy)-carbanilate; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethyl)-carbanilate; and methyl 2-(p-chlorophenyl)-5-methyl-4-{[p-(trifluoromethoxy)phenyl]carbamoyl}-Δ2-1,3,4-oxadiazoline-5-acetate.
13. A composition for the control of insect or acarid pests which comprises an agronomically acceptable carrier and a pesticidally effective amount of a compound having the structural formula whereinR is halogen, C1-C4haloalkyl, C1-C4haloalkoxy or phenoxy optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; R4 is C1-C4haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio; R1 is C1-C4alkyl; R2 is C1-C4alkyl, C1-C4haloalkyl, (CH2)vC(O)R12 or 2-pyridyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; v is 0 or 1; R12 is C1-C4alkoxy or C1-C4haloalkoxy; R3 is hydrogen, C1-C6alkyl or C(O)R15; and R15 is C1-C4alkoxy.
14. The composition according to claim 13 whereinR is F, Br, Cl or phenoxy; R4 is CF3, OCF3 or SCF3; R1 is CH3; R2 is CH3, CH2Cl, CH2CF3, CF3, CH2CO2CH3 or 2-pyridyl; and R3 is hydrogen or CO2CH3.
15. The composition according to claim 14 wherein the compound is selected from the group consisting of2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-fluorophenyl)-5,5-dimethyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5,5-dimethyl-2-(p-phenoxyphenyl)-4′-[(trifluoromethyl)-thio]-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethoxy)-5-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-chlorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 4,5-bis(trifluoromethyl)-2-(p-fluorophenyl)-5-methyl-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 5-(chloromethyl)-2-(p-fluorophenyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-bromophenyl)-5-(chloromethyl)-5-methyl-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2,2,2-trifluoroethyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethyl)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; 2-(p-chlorophenyl)-5-methyl-5-(2-pyridyl)-4′-(trifluoromethoxy)-Δ2-1,3,4-oxadiazoline-4-carboxanilide; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethoxy)-carbanilate; methyl N-{[2-(p-chlorophenyl)-5,5-dimethyl-Δ2-1,3,4-oxadiazolin-4-yl]carbonyl}-p-(trifluoromethyl)-carbanilate; and methyl 2-(p-chlorophenyl)-5-methyl-4-{[p-(trifluoromethoxy)phenyl]carbamoyl}-Δ2-1,3,4-oxadiazoline-5-acetate.
16. A composition for the control of insect or acarid pests which comprises an agronomically acceptable carrier, and an insecticidal or acaricidal effective amount of a compound having the structural formula whereinX is O or S(O)m; Z is C(X1)R5, C1-C6alkyl, C1-C6haloalkyl, or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; X1 is O or S; R and R4 are each independently halogen, C1-C6alkyl, C1-C6haloalkyl, OR6, S(O)qR7, nitro, cyano, NR8R9, CO2R10, C(O)R11 or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or two adjacent R groups or R4 groups may be taken together to form a ring wherein RR or R4R4 is represented by: —OCH2O—, —OCF2O— or —CH═CH—CH═CH—; R6 and R7 are each independently hydrogen, C1-C6alkyl, C1-C6haloalkyl or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C4haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; R8, R9, R13 and R14 are each independently hydrogen, C1-C6alkyl, C1-C6alkylcarbonyl or phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; R10 and R11 are each independently hydrogen, C1-C6alkyl or C1-C6haloalkyl; R1 and R2 are each independently hydrogen, C3-C7cycloalkyl, C1-C6haloalkyl, C3-C6alkenyl, C3-C6haloalkenyl, C3-C6alkynyl, C3-C6haloalkynyl, C2-C6alkoxyalkyl, (CH2)vC(O)R12, C1-C6alkyl optionally substituted with one phenoxy or phenyl group wherein the phenyl ring of each group is independently, optionally substituted with from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, phenyl optionally substituted with from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or a 5- or 6-membered heteroaromatic ring optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, and when R1 and R2 are taken together with the atom to which they are attached they may form a C3-C6cycloalkyl ring wherein R1R2 is represented by: —(CH2)t— where t is 2, 3, 4 or 5; m, q and v are each independently 0, 1 or 2; R12 is hydrogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio, C1-C6haloalkylthio or NR13R14; R3 is hydrogen, C1-C6alkyl, C1-C6haloalkyl or C(O)R15; R15 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy or C1-C6haloalkoxy; and R5 is C1-C6alkyl, phenyl optionally substituted with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups, or benzyl optionally substituted on the phenyl ring with any combination of from one to three halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylthio or C1-C6haloalkylthio groups; and the optical isomers thereof and the agriculturally acceptable salts thereof, provided that: (1) R is other than CO2R10 when R is on the ortho-position of the phenyl ring, and (2) R2 is other than ethyl or unsubstituted phenyl when X is O, n and p are 0 and R1 is methyl.

Parent Case Info

This application claims priority from copending provisional application(s) Ser. No. 60/109,448 filed on Nov. 23, 1998.

US Referenced Citations (1)

Number	Name	Date	Kind
5670456	Anderson et al.	Sep 1997

Non-Patent Literature Citations (3)

Entry
D. Kochetov et al., Ukrainskii Khimicheskii Zhurnal, 57(2), 215-217 (1991).
Matsubara et al., “Synthesis of Novel 2-substituted-1,3,4-thiadiazoles” Chem. Pharm. Bull. 46 329-331 (1998).
Matsubara Chem Pharm Bull 46 (2) 329-31Feb. 1998, Abstract.

Provisional Applications (1)

	Number	Date	Country
	60/109448	Nov 1998	US

2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents

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2-aryl-&#x0394;2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents

Information

Patent Number

Date Filed

Date Issued

Inventors

Original Assignees

Examiners

Agents

CPC

US Classifications

Field of Search

US

International Classifications

Abstract

Description

Claims

Parent Case Info

US Referenced Citations (1)

Non-Patent Literature Citations (3)

Provisional Applications (1)

2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents