Claims
- 1. A compound of the formula ##STR258## where R is H or CH.sub.3 ;
- P' is a removable protecting group for hydroxy;
- R.sup.a is selected from the group consisting of H, Cl, Br, I, SMe, CN, CHO, SOMe, SO.sub.2 Me, and OP';
- M is a removable protecting group for carboxyl; and
- Z is an effective leaving group selected from the group consisting of alkyl and substituted alkylsulfonates, aryl and substituted arylsulfonates, and halides.
- 2. The compound of claim 1 wherein M is selected from the group consisting of benzhydryl, p-nitrobenzyl, 2-naphthylmethyl, allyl, benzyl, trichloroethyl, trimethylsilyl, t-butyldiphenylsilyl, phenacyl, p-methoxybenzyl, acetonyl, o-nitrobenzyl and 4-pyridylmethyl.
- 3. The compound of claim 1 wherein P' is selected from the group consisting of methoxy-t-butylphenylsilyl, t-butoxydiphenylsilyl, trimethylsilyl, triethylsilyl, o-nitrobenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, benzyloxycarbonyl, t-butyloxycarbonyl, 2,2,2-trichloroethyloxycarbonyl and allyloxycarbonyl.
- 4. The compound of claim 1 wherein Z is selected from the group consisting of methanesulfonyloxy, trifluoromethanesulfonyloxy, fluorosulfonyloxy, p-toluenesulfonyloxy, 2,4,6-triisopropylbenzenesulfonyloxy, p-bromobenzenesulfonyloxy, p-nitrobenzenesulfonyloxy, bromo and iodo.
Parent Case Info
This is a continuation of application Ser. No. 594,886, filed Oct. 9, 1990, now abandoned.
US Referenced Citations (15)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0277743 |
Aug 1988 |
EPX |
Non-Patent Literature Citations (2)
Entry |
L. D. Cama et al., Total Synthesis of Thienamycin Analogs-III, Tetrahedron 39, 2531 (1983). |
R. N. Guthikonda, et al., Structure Activity Relationships in the 2-Arylcarbapenem Series, J. Med. Chem., 30, 871 (1987). |
Continuations (1)
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Number |
Date |
Country |
Parent |
594886 |
Oct 1990 |
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