2-Decarboxy-2-hydroxymethyl-16-fluoro-PGE.sub.2 compounds

Abstract

This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Description

The present invention is related to pharmacologically active 2-decarboxy-2-hydroxymethyl-16-fluoro-PGE.sub.2 compounds whose preparation and use is described in U.S. Pat. No. 4,032,576, issued June 28, 1977, the relevant disclosure of which is hereby incorporated by reference.

Claims

1. A prostaglandin analog of the formula ##STR1## wherein M.sub.1 is ##STR2## wherein R.sub.5 is hydrogen or methyl; wherein L.sub.1 is ##STR3## or a mixture of ##STR4## wherein R.sub.3 and R.sub.4 are hydrogen or fluoro, being the same or different;

wherein g is one, 2, or 3; and

wherein m is one to 5, inclusive:

with the proviso that at least one of R.sub.3 and R.sub.4 is fluoro.