2-Decarboxy-2-hydroxymethyl)-16-fluoro-PGE.sub.2 compounds

Abstract

This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive cycle regulation, gastric antisecretory action, and the like.

Description

Claims

1. A prostaglandin analog of the formula ##STR1## wherein M.sub.1 is ##STR2## wherein R.sub.5 is hydrogen or methyl;

Wherein g is one, 2, or 3; and

Wherein m is one to 5, inclusive.

2. 2-Decarboxy-2-hydroxymethyl-16,16-difluoro-PGE.sub.2.