TREA

2-Decarboxy-2-hydroxymethyl-PGF.sub.1 .alpha. analogs

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Information

  • Patent Grant
  • 4171460
  • Patent Number
    4,171,460
  • Date Filed
    Wednesday, April 6, 1977
    48 years ago
  • Date Issued
    Tuesday, October 16, 1979
    46 years ago
Information
Abstract
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Description
Claims
  • 1. A prostaglandin analog of the formula ##STR1## wherein M.sub.1 is ##STR2## wherein R.sub.5 is hydrogen or methyl; WHEREIN G IS ONE, 2, OR 3; AND
  • Wherein m is one to 5, inclusive.
  • 2. A compound according to claim 1, wherein m is one or 2.
  • 3. A compound according to claim 1, wherein m is 4 or 5.
  • 4. A compound according to claim 1, wherein m is 3.
  • 5. A compound according to claim 4, wherein g is one.
  • 6. A compound according to claim 5, wherein R.sub.5 is hydrogen.
  • 7. 2-Decarboxy-2-hydroxymethyl-16,16-difluoro-PGF.sub.1 .alpha..
Parent Case Info

The present application is a divisional application of Ser. No. 647,369 filed Jan. 8, 1976, now issued as U.S. Pat. No. 4,032,576 on June 28, 1977.

US Referenced Citations (5)
Number Name Date Kind
3914282 Pike Oct 1975
3932463 Schaub et al. Jan 1976
3933889 Magerlein Jan 1976
3959346 Schneider May 1976
3962293 Magerlein Jun 1976
Non-Patent Literature Citations (2)
Entry
Derwent Farmdoc, CPI 22,600 (Jan. 9, 1966).
Burger, "Medicinal Chemistry", pp. 81-82 (1960).
Divisions (1)
Number Date Country
Parent 647369 Jan 1976