2-Decarboxy-2-hydroxymethyl PGF.sub.2 .alpha.analogs

Abstract

This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

Description

Claims

1. A prostaglandin analog of the formula ##STR1## wherein M.sub.1 is ##STR2## or ##STR3## wherein R.sub.5 is hydrogen or methyl; wherein L.sub.3 is ##STR4## or a mixture of ##STR5## and ##STR6## wherein one of R.sub.3 and R.sub.4 is fluoro and the other is hydrogen or fluoro;

wherein g is one, 2, or 3; and

wherein m is one to 5, inclusive.