Claims
- 1. A prostacyclin of formula ##STR2## wherein W.sub.1 is .alpha.-OH:.beta.-H, .alpha.-H:.beta.OH, oxo, methylene, .alpha.-H:.beta.-H, .alpha.-CH.sub.2 OH:.beta.-H;
- wherein L is
- (1) -(CH.sub.2).sub.d -C(R.sub.2).sub.2,
- (2) -CH.sub.2 -O-CH.sub.2 -Y-, or
- (3) -CH.sub.2 CH.dbd.CH-,
- wherein d is zero to 5, R.sub.2 is hydrogen, methyl, or fluoro, being the same or different with the proviso that one R.sub.2 is not methyl when the other is fluoro, and wherein Y is a valence bond, -CH.sub.2 - or -(CH.sub.2).sub.2,
- wherein Q is keto, .alpha.-H:.beta.-H, .alpha.-OH:.beta.R.sub.8 or .alpha.-R.sub.8 :.beta.-OH
- wherein R.sub.8 is hydrogen or alkyl of one to 4 carbon atoms, inclusive;
- wherein R.sub.5 and R.sub.6 hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R.sub.5 and R.sub.6 is fluoro only when the other is hydrogen or fluoro and the further proviso that neither R.sub.5 nor R.sub.6 is fluoro when Z is oxa (-O-); wherein Z represents an oxa atom (-O-) or C.sub.j H.sub.2j, wherein C.sub.j H.sub.2j is a valence bond or alkylene of one to 9 carbon atoms, inclusive, with one to 6 carbon atoms, inclusive, between CR.sub.5 R.sub.6 - and the phenyl ring; wherein T is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or -OR.sub.7 -, wherein R.sub.7 is alkyl of one to 4 carbon atoms, inclusive, and s is zero or one; and
- wherein X is
- (1) trans-CH.dbd.CH-,
- (2) cis-CH.dbd.CH-,
- (3) -C.quadbond.C-, or
- (4) -CH.sub.2 CH.sub.2 -;
- including the lower alkanoates thereof.
CROSS REFERENCE TO RELATED APPLICATION
The present application is a divisional application of copending application Ser. No. 959,400, filed Nov. 9, 1978; now U.S. Pat. No. 4,215,222 which is a divisional application of Ser. No. 819,857, filed July 28, 1977, now U.S. Pat. No. 4,158,667; which is a continuation-in-part of Ser. No. 725,548, filed Sept. 22, 1976, now abandoned; which is a continuation-in-part of Ser. No. 716,972, filed Aug. 23, 1976, now abandoned; which is a continuation-in-part of Ser. No. 655,110, filed Feb. 4, 1976, now abandoned.
US Referenced Citations (8)
Divisions (2)
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Number |
Date |
Country |
| Parent |
959400 |
Nov 1978 |
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| Parent |
819857 |
Jul 1977 |
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Continuation in Parts (3)
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Number |
Date |
Country |
| Parent |
725548 |
Sep 1976 |
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| Parent |
716972 |
Aug 1976 |
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| Parent |
655110 |
Feb 1976 |
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Patent Grant
4410695
