Claims
- 1. A method of preparing an acid addition salt of a 2-isoxazoline derivative represented by formula (2) or formula (3) which comprises
- optically resolving a mixture of 2-isoxazoline derivatives represented by formula (2) and formula (3) or a mixture of the acid addition salt thereof and an optically active acid: ##STR9## wherein Ph represents phenyl; and each of R.sup.1 and R.sup.2 independently represents hydrogen, acyl, alkyloxycarbonyl, arylalkyloxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, arylalkylaminocarbonyl, arylaminocarbonyl, alkyl, arylalkyl, aryl, alkylsulfonyl, arylalkylsulfonyl, or arylfulfonyl, or R.sub.1 and R.sup.2 are linked to each other to form divalent acyl.
- 2. The method according to claim 1 wherein R.sup.1 and R.sup.2 are each hydrogen.
- 3. The method according to claim 2, wherein the optically active acid is (S)-mandelic acid, and the compound to be obtained is (5S,1'S)-3-phenylmethyl-5-(1'-amino-2'-phenylethyl)-2-isoxazoline (S)-mandelate.
- 4. The method according to claim 2, wherein the optically active acid is (R)-mandelic acid, and the compound to be obtained is (5R,1'R)-3-phenylmethyl-5-(1'amino-2'-phenylethyl)-2-isoxazoline (R)-mandelate.
Priority Claims (2)
Number |
Date |
Country |
Kind |
6-56639 |
Mar 1994 |
JPX |
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6-183973 |
Jul 1994 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 08/702,582, filed May 25, 1995, now U.S. Pat. No. 5,750,717, which in turn is a .sctn.371 application of PCT/JP95/00331 filed in Japan on Mar. 2, 1995.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5354866 |
Kempf et al. |
Oct 1994 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
9414436 |
Jul 1994 |
WOX |
Divisions (1)
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Number |
Date |
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Parent |
702582 |
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