2-Methyl-2-buten-1-yl tiglate

Abstract

The invention is concerned with a novel odorant and/or flavoring substance, namely, 2-methyl-2-buten-1-yl tiglate of the formula ##STR1## The invention is also concerned with a process for the manufacture of the compound of formula I, the compound of formula I as an odorant and/or flavoring substance and odorant and/or flavoring compositions containing the compounds of formula I.

Description

FIELD OF THE INVENTION

This invention relates to flavorants and odorants.

SUMMARY OF THE INVENTION

See the foregoing "Abstract of the Disclosure."

The synthetic process provided by the present invention for the manufacture of the compound of formula I comprises esterifying 2-methyl-2-buten-1-ol with tiglic acid or a reactive derivative thereof, or trans-esterifying a tiglic acid lower alkyl ester with 2-methyl-2-buten-1-ol, or reacting a 2-methyl-2-buten-1-yl halide with an alkali metal salt of tiglic acid.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The esterification of 2-methyl-2-buten-1-ol with tiglic acid or a reactive derivative thereof and the reaction of a 2-methyl-2-buten-1-yl halide with an alkali metal salt of tiglic acid can be carried out according to methods known per se; for example, in accordance with the details given in Table I (see also "Organikum", Org. Chem. Grundpraktikum, VEB Deutscher Verlag der Wissenschaften, Berlin 1969, 9. Edition, p. 440 et seq.).

TABLE I______________________________________ Solvent Temp.Acid component Alcohol Medium e.g. e.g.______________________________________Tiglic acid 2-Methyl-2- acidic.sup. 0 Benzene, 25.degree.-75.degree. C. buten-1-ol toluene.about.anhydride 2-Methyl-2- basic.sup. 2 Benzene, " buten-1-ol toluene.about.halide 2-Methyl-2- " Benzene, " buten-1-ol.sup.1 toluene.about.alkali metal 2-Methyl-2- neutral Benzene, "salt buten-1-yl toluene halide.sup. 3______________________________________ .sup.0 paratoluenesulphonic acid, cation exchanger; .sup.1 or alcoholate (e.g. sodium or potassium alcoholate); .sup.2 pyridine, dimethylaniline etc; .sup.3 especially the chloride.

In the trans-esterification of a tiglic acid lower alkyl ester with 2-methyl-2-buten-1-ol there is preferably used the methyl or ethyl ester, since in this case the low-boiling alcohol methanol or ethanol which is formed can readily be distilled off. The compound of formula I has particular organoleptic properties, on the basis of which it is excellently suited as an odorant and/or flavouring substance.

The invention is therefore also concerned with the use of the compound of formula I as an odorant and/or flavouring substance.

The compound of formula I used in accordance with the present invention as an odorant and/or flavouring substance possesses an original and, for an ester containing this number of carbon atoms, very surprising odour. This can be described as follows: reminiscent of damp forest soil, fungus-like (mushroom), slightly anis-like, flowery, delicate, with aspects of the odour of young leaf buds. The complete absence of the fruity note and the appearance of typical flowery nuances and the prominence of the natural forest soil character are remarkable.

Tiglates have recently enjoyed increasing popularity as odorant substances. However, among them there have been found no representatives which are organoleptically comparable with the compound of formula I hereinabove.

S. Arcander describes in "Perfume and Flavor Chemicals" (1969, Montclair NJ, USA) e.g. the following structurally analogous tiglates:

______________________________________No. 1630: cis-3-hexenyl tiglate fresh, powerful, ##STR2## dark green leaves with slight fruity undertone.No. 1631: trans-2-hexenyl tiglate warm-herby, green ##STR3## odour with slight fruity undertone.No. 1682: n-hexyl tiglate pleasant, sweet- green oily, herby and slightly vinous odour which is rem- iniscent of unripe berries or plums.No. 225: iso-amyl tiglate pleasant herby and vinous odour, rem- iniscent of medicinal herbs.No. 540: n-butyl tiglate warm-herby, diffuse, ethereal and sweet.______________________________________

Again, the olfactory comparison with 2-methyl-2-buten-1-yl 2-methylbutyrate 2, 2-methyl-butyl tiglate 3 and prenyl senecioate 4, known as an insect combating agent (Swiss Patent Specification No. 264,520, Jan. 16, 1950 and U.S. Pat. No. 2,554,947, May 29, 1951), also shows, moreover, that none of these compounds has the typical olfactory properties of 2-methyl-2-buten-1-yl tiglate of formula I and only this tiglate alone, which is reminiscent of damp forest soil, at the same time also combines in its molecule delicate-flowery and bud-like odour combinations without any fruity aspect.

______________________________________ Odour______________________________________ ##STR4## ester-like, fruity, berry- like, aspects of elder. ##STR5## herby, sweet with green and slightly fruity undertone. ##STR6## warm-herby, green, chervil-like.______________________________________

The compound of formula I can therefore be used, for example, for the perfuming or flavouring of products such as cosmetics (soaps, ointments, powders, toothpastes, mouth washes, deodorants, shampoos, lotions etc), detergents, foodstuffs, luxury consumables and drinks, the compound of formula I preferably not being used alone but in the form of compositions which contain other odorant or flavouring substances. Such odorant or flavouring compositions containing the compound of formula I and their manufacture carried out in a manner known per se (addition of the compound of formula I to known odorant or flavouring compositions or mixture of the compound of formula I with natural or synthetic compounds or mixtures suitable as the ingredients of odorant or flavouring compositions) also form objects of the present invention.

On the basis of its aforementioned original notes, the compound of formula I is suitable as an odorant substance, especially in combination with a series of natural and synthetic odorant substances such as, for example:

patchouli oil, pine-needle absolute, tree moss absolute, frankincense balsam, sandalwood oil, basil oil, mugwort oil, camomile oil, sage oil, tagetes oil, ylang-ylang oil, bergamot oil, lemon oil, petitgrain oil, neroli oil etc, aldehydes such as hydroxycitronellal, .alpha.-hexylcinnamaldehyde, lauric aldehyde, methylnonylacetaldehyde, Cyclal.RTM. (2,4-dimethyl-3-cyclohexenyl-1-carboxaldehyde), citral, cyclamen aldehyde, anisaldehyde etc, ketones such as .alpha.-ionone, .beta.-ionone, methylionone etc, acetals and ketals such as Acetal CD.RTM. (Givaudan) (phenylacetaldehyde glycerinacetal), Fructone.RTM. (2-methyl-1,3-dioxolan-2-ethyl acetate) etc, ethers such as eucalyptol, methyl p-cresol, anethol, methyl 1-methylcyclododecyl ether etc, phenolic compounds such as eugenol, isoeugenol etc, alcohols such as linalool, citronellol, geraniol, cinnamic alcohol, benzyl alcohol, phenylethyl alcohol, .alpha.-terpineol etc, esters such as linalyl acetate, bornyl acetate, vetiveryl acetate, geranyl acetate, benzyl acetate, benzyl salicylate, amyl salicylate, styrallyl acetate, phenylethyl phenylacetate, methyl dihydrojasmonate etc, lactones such as .gamma.-nonalactone, .gamma.-decalactone, .gamma.-undecalactone, .delta.-decalactone etc, acids such as phenylacetic acid .alpha.-methylbutyric acid etc, compounds having a musk-like and amber-like odour such as ethylene brassylate, musk ketone, 8.alpha.,12-oxido-13,14,15,16-tetranorlabdane etc, sulphur-containing compounds such as p-menthane-8-thiol-3-one etc, nitrogen-containing compounds such as methyl anthranilate, linalyl anthranilate etc.

As will be evident from Examples 2-8 hereinafter, extremely interesting effects can be achieved with the compound of formula I. In addition to producing valuable and original effects in odorant compositions of the chypre, cologne, wood, jasmine or rose type or in compositions having a generally flowery direction it is, however, also possible to produce novel perfume complexes with 2-methyl-2-buten-1-yl tiglate of formula I. Thus, for example, flowery-fruity complexes from linalool and a lactone (e.g. .delta.-decalactone) are harmonised and enriched by an additional exotic aspect by adding 1-5% of the compound of formula I. The compound of formula I can also be used in the reconstitution of essential oils or absolutes.

In the production of such compositions the known odorant substances specified earlier can be used according to methods which are known to the perfumer such as, for example, as described by W. A. Poucher, Perfumes, Cosmetics and Soaps 2, 7th Edition, Chapman and Hall, London, 1974.

The concentration of the compound of formula I can vary within wide limits depending on the purpose of use, for example between about 0.01 wt.% in the case of detergents and about 15 wt.% in the case of alcoholic solutions. In perfume bases or concentrates the concentrations can, of course, also be higher. The perfume bases can be used in the customary manner for the perfuming of Eau de Cologne, eau de toilette, extracts, lotions, creams, shampoos, soaps, detergents etc. The use of the compound of formula I in colognes and extracts is preferred.

As a flavouring substance, the compound of formula I can be used, for example, for the production or improvement, enhancement or modification of various flavour types such as those used, for example, for the flavouring of foodstuffs (yoghurt, sweet goods, e.g. candies, etc), luxury consumables (tea etc), and drinks (lemonades etc). In particular, interesting effects in the modification of strawberry or herb tea flavours can be produced by adding the compound of formula I (see Table II hereinafter).

The pronounced flavour qualities of the compound of formula I enables it to be used in low concentrations. A suitable range is, for example, 0.1 ppm-100 ppm, preferably 1 ppm-20 ppm, in the finished product (i.e. the flavoured foodstuff, luxury consumable or drink).

In Table II hereinafter there are compiled effects which can be achieved with the compound of formula I.

TABLE II______________________________________Flavour Amount Effect______________________________________Herb tea ppm More complete in the finished product flavour, more 0.1-30 ppm, character especially 0.5-4 ppmStrawberry ppm Modification in the in the finished product direction of 0.1-100 ppm, cranberries especially 1-20 ppm______________________________________

The compound of formula I can be mixed with the ingredients used for flavouring compositions or added to such flavourants in the customary manner. Among the flavourants contemplated in accordance with the invention there are to be understood flavouring compositions which can be diluted or dispersed in edible materials in a manner known per se. The flavouring compositions provided by this invention can be converted according to methods known per se into the customary forms of use such as solutions, pastes or powders. The present flavouring compositions can be spray-dried, vacuum-dried or lyophilised.

The known flavouring substances conveniently used in the production of such flavourants are either included in the foregoing compilation or can readily be selected from the literature; for example, from J. Merory, Food Flavorings, Composition, Manufacture and Use, Second Edition, The Avi Publishing Company, Inc., Westport, Conn. 1968, or G. Fenaroli, Fenaroli's Handbook of Flavor Ingredients, Second Edition, Volume 2, CRC Press Inc., Cleveland, Ohio, 1975.

For the production of such customary forms of use there come into consideration, for example, the following carrier materials, thickening agents, flavour-improvers, spices, auxiliary ingredients etc:

Gum arabic, tragacanth, salts or brewer's yeast, alginates, carrageen or similar absorbants; indole, maltol, spice oleoresins, smoke flavours; cloves, sodium citrate; monosodium glutamate, disodium inosine-5'-monophosphate (IMP), disodium guanosine-5-phosphate (GMP); or special flavouring substances, water, ethanol, propyleneglycol, glycerin.

The following Examples illustrate the present invention:

EXAMPLE 1

A solution of 133.6 g (1.13 mol) of tiglic acid chloride in 100 ml of toluene was allowed to drop into a solution of 106.2 g (1.24 mol) of 2-methyl-2-buten-1-ol and 172.5 g (1.43 mol) of dimethylaniline in 350 ml of toluene over a period of 30 minutes. The mixture was subsequently stirred for 16 hours at 40.degree. C., cooled to room temperature, diluted with 200 ml of ether, washed with dilute hydrochloric acid until the excess dimethylaniline had been completely removed and then with water until neutral. After drying over sodium sulphate and concentration, there were obtained 212 g of crude compound of formula I from which 131.5 g of pure and olfactorily good compound of formula I of boiling point 92.degree. C./12 mmHg were obtained by distillation over a 20 cm Widmer column.

Spectral data

IR: 1715, 1265, 1255, 1155, 1138, 1072, 732 cm.sup.-1. NMR: 1.6-1.9 (4CH.sub.3 on double bonds, mutually overlapping) 4.58 ##STR7## 5.61 ##STR8## 6.90 ##STR9## MS: 168 (M+, 2), 139 (8), 123 (8), 101 (13), 83 (100), 69 (32), 55 (55), 41 (43), 39 (23), 27 (21).

EXAMPLE 2

______________________________________Perfume base direction of chypre Parts by weight______________________________________Bergamotte oil 200Hydroxycitronellal 160Linalool 120Patchouli oil 60.beta.-Ionone 6012-Oxahexadecanolide 60Bornyl acetate 60Tree moss absolute 60Lemon oil 60Vetivenyl acetate 60Indole (10% in ethanol) 20Mugwort oil 20Pine-needle balsam absolute 10Eugenol extra 10Rhodinol pure 20 980______________________________________

If there are added to this conventional chypre composition 20 parts of the compound of formula I, then the original composition takes on a much fresher top note, the bergamotte oil is underlined advantageously and the resulting composition is more delicate and lighter.

EXAMPLE 3

______________________________________Flowery base for use in perfumery Parts by weight______________________________________Benzyl acetate 180Linalool 120Isoeugenol 100Geranyl acetate 100Methyl benzoate 100Geraniol 100Linalyl acetate 50Benzyl salicylate 40Hydroxycitronellal 30Amyl salicylate 30Methylionone 30Cinnamic alcohol 20Musk ketone 20Heliotropin 5Eugenol 5Methyl p-cresol 5Linalyl anthranilate 5 960______________________________________

If there are added to this flowery base, which tends in the direction of ylang, 40 parts of the compound of formula I, then the resulting composition is much more delicate, generally flowery and much more diffuse. This effect can be detected very well even after 24 hours.

EXAMPLE 4

______________________________________Perfumery base direction of Eau de Cologne Parts by weight______________________________________Bergamotte oil 404Lemon oil 120a-Hexylcinnamaldehyde 100Methyl dihydrojasmonate 60.alpha.-Ionone 60Basil oil 50Rhodinol pure 40Eugenol 40Neroli oil 40Patchouli oil 20Tree moss absolute (50% in 20propyleneglycol)Vetivenyl acetate 20Ylang-ylang oil 20 994______________________________________

If there are added to this Eau de Cologne 6 parts of the compound of formula I, then the resulting composition is much fresher and more powerful, and there results a very pleasant aromatic citrus peel note which is not present in the original base. With increasing concentration (1% and 2%) there results a very original and sharp effect which confers more life to the composition and makes it especially suitable for mens colognes.

EXAMPLE 5

______________________________________Perfumery base general-flowery direction Parts by weight______________________________________Benzyl alcohol 500Phenylethyl alcohol 250Hexylcinnamaldehyde 70Benzyl acetate 60Linalool 40Indole (10% in propyleneglycol) 20Linalyl anthranilate 10.delta.-Undecalactone (10% in propylene- 10glycol) 960______________________________________

The addition of 40 parts of the compound of formula I to this base which has a general-flowery odour surprisingly brings about a significant modification of the odour in the direction of hyacinth. The novel modified base has more character and radiance.

EXAMPLE 6

______________________________________Fresh-green base for use in perfumery Parts by weight______________________________________Bornyl acetate 200Methyl 1-methylcyclododecyl 160ether.alpha.Hexylcinnamaldehyde 140Linalool 100Frankincense balsam 801,1,2,4,4,7-Pentamethyl-6- 60acetyl-1,2,3,4-tetrahydro-naphthalene.alpha.-Terpineol 60.alpha.-Ionone 60Styrallyl acetate 30Linalyl anthranilate 20Dodecanal (10% in ethanol) 10Methylnonylacetaldehyde (10% in 10ethanol)3,5-Dimethyl-cyclohex-3-en-1- 6carbaldehydep-Menthane-8-thiol-3-one 4Tree moss absolute 10Citral 20 970______________________________________

If there are added to this fresh-green base 30 parts of the compound of formula I, then the resulting composition is much more powerful and more natural. A very pleasant forest smell is established. The bornyl acetate is pleasantly and significantly emphasised.

EXAMPLE 7

______________________________________Woody perfume base Parts by weight______________________________________Phenylethyl phenylacetate 170Phenylethyl alcohol 100Phenylacetaldehyde glycerylacetal 100Methyl dihydrojasmonate 100Sandalwood oil 120Benzyl salicylate 120Methyl 1-methylcyclododecyl ether 120Hydroxycitronellal 60Ethylene brassylate 40Linalool 20Eugenol 20Cyclamen aldehyde 20 990______________________________________

If there is added to this base which has a generally woody direction 0.5% of the compound of formula I, then the resulting composition is pleasantly flowery and is especially suitable for delicate, especially flowery, directions with a woody bottom note. If the concentration is increased up to 2%, then the wood note likewise appears more in the foreground and it manifests itself in a very fine sandal note which is especially prominent in the bottom note.

EXAMPLE 8

______________________________________Herb tea flavour Parts by weight______________________________________Petitgrain oil (French) 220Anethol 150Camomile oil (Roman) 120Tagetes oil 110Eucalyptol 100Linalyl anthranilate 100Phenylethyl phenylacetate 60Anisaldehyde 60Sage oil (Dalmatian) 20Neroli oil 10 950______________________________________

The addition of 50 parts of 2-methyl-2-butenyl tiglate to the foregoing conventional herb tea flavour brings about a very pleasant rounding-off effect in that an intensified flowery note appears. Flavourwise, with the use of 50 g of a 2% solution of this flavour in glyceryl triacetate per 100 liters of sugar syrup 65.degree. Bx, diluted with water in the ratio 1:5, there is likewise ascertainable a significant improvement in that, in comparison with a blind sample, the tea is now more rounded-off and, moreover, by virtue of an additional flowery note, is reminiscent of certain kinds of black tea.

Claims

1. 2-Methyl-2-buten-1-yl tiglate provided it is not part of a naturally occurring mixture of compounds or part of a synthetic mixture which is the same as said naturally occurring mixture of compounds.