Claims
- 1. A compound of the formula ##STR7## wherein each of X and Y are halogeno, (n) is an integer of zero to three, an R is methylsulfinylacetyl, methylsulfonylacetyl, methylthiohydroxyacetyl, methylthioalkoxyacetyl, methylsulfonylhydroxyethyl, or methylsulfonylhydroxyethyl.
- 2. A compound of claim 1 wherein R is methylsulfonylacetyl.
- 3. A compound of claim 1 wherein R is methylsulfinylacetyl.
- 4. A compound of claim 1 wherein X.sub.(n) represents a monohalogenated substituent.
- 5. A compound of claim 1 wherein X.sub.(n) represents dihalogenated substituents.
- 6. A compound of claim 1 wherein X.sub.(n) represents trihalogenated substituents.
- 7. A compound of claim 1 wherein X.sub.(n) represents dihalogenated substituents and Y.sub.(n) represents a monohalogenated substituent.
- 8. A compound of claim 1 wherein X.sub.(n) represents 6-bromo-5-chloro, Y.sub.(n) represents zero and R represents methylsulfinylacetyl, said compound being 6-bromo-5-chloro-2[(methylsulfinyl)acetyl]-3-phenylindole.
- 9. A compound of claim 1 wherein X.sub.(n) represents, 5,6-dichloro, Y.sub.(n) represents 3,4-dichloro, R represents methylsulfinylacetyl, said compound being 5,6-dichloro-2-[(methylsulfinyl)acetyl]-3-(3,4-dichlorophenyl)indole.
- 10. A compound of claim 1 wherein X.sub.(n) represents 6-bromo-5-chloro, R represents methylsulfonylacetyl, said compound being 6-bromo-5-chloro-[(methylsulfonyl)acetyl]-3-phenylindole.
- 11. A compound of claim 1 wherein X.sub.(n) represents 5-chloro, Y represents 2-fluoro and R represents methylsulfinyl, said compound being 5-chloro-2-[(methylsulfinyl)acetyl]-3-(2-fluorophenyl)indole.
- 12. A compound of claim 1 wherein X.sub.(n) represents 6-bromo-5-chloro, Y.sub.(n) represents 2-fluoro and R represents methylsulfinyl, said compound being 6-bromo-5-chloro-3-(2-fluorophenyl)-2-[(methylsulfinyl)acetyl]indole.
- 13. A compound of claim 1 wherein X.sub.(n) represents zero, Y.sub.(n) represents 2-fluoro and R represents methylsulfinylacetyl, said compound being 5,6-dichloro-2-[(methylsulfinyl)acetyl]-3-phenylindole.
- 14. A compound of claim 1 wherein X.sub.(n) represents 4,5,6-trichoro and R represents methylsulfinylacetyl, said compound being 4,5,6-trichloro-2-[(methylsulfinyl)acetyl]-3-phenylindole.
- 15. A compound of claim 1 wherein X.sub.(n) represents 5-chloro, Y represents, 2,6-difluoro and R represents methylsulfinylacetyl, said compound being 5-chloro-2-[(methylsulfinyl)acetyl]-3-(2,6-difluorophenyl)indole.
- 16. A compound of claim 1 wherein X.sub.(n) represents 5-chloro, Y.sub.(n) represents 2,4-dichloro and R represents methylsulfinylacetyl, said compound being 5-chloro-2-[(methylsulfinyl)acetyl]-3-(2,4-dichlorophenyl)indole.
- 17. A method for treating rheumatoid arthritis which comprises administering to a mammal suffering from rheumatoid arthritis a therapeutically effective quantity of a compound having the formula ##STR8## wherein each of X and Y are halogen, (n) is an integer of zero to three, and R is methylsulfinylacetyl, methylsulfonylacetyl, methylthiohydroxyacetyl, methylthioalkoxyacetyl, methylsulfinylhydroxylethyl, or methylsulfonylhydroxyethyl together with a pharmaceutically acceptable carrier.
- 18. A method of eliciting an immunosuppressant response in a mammal suffering from a disease state responsive to an immunosuppressant which comprises administering a therapeutically effective amount of a compound of the formula ##STR9## wherein each of X and Y are halogeno, (n) is an integer of zero to three, and R is methylsulfinylacetyl, methylsulfonylacetyl, methylthiohydroxyacetyl, methylthioalkoxyacetyl, methylsulfinylhydroxyethyl, or methylsulfonylhydroxyethyl together with a pharmaceutically acceptable carrier.
- 19. A pharmaceutical composition useful in treating rheumatoid arthritis or eliciting an ummuno suppressant response comprising an effective amount of a compound according to any one of claims 1 to 16 and a pharmaceutically acceptable carrier.
Parent Case Info
This application is a continuation-in-part application of our copending application Ser. No. 930,274, filed Aug. 2, 1978, abandoned which in turn is a continuation-in-part application of Application Ser. No. 828,355, filed Aug. 29, 1977, now abandoned.
US Referenced Citations (3)
Non-Patent Literature Citations (1)
Entry |
Hirai et al., Chem. Abs. 80, 133414m (1972). |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
930274 |
Aug 1978 |
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Parent |
828355 |
Aug 1977 |
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