Claims
- 1. A compound of the formula ##STR13## wherein R.sub.1 is (unsubstituted phenyl)-(alkyl of 1 to 4 carbon atoms)-amino or N-(alkyl of 1 to 4 carbon atoms)-(unsubstituted phenyl)-(alkyl of 1 to 4 carbon atoms)-amino;
- R.sub.2 is thiomorpholino, thiomorpholino-1-oxide or thiomorpholino-1,1-dioxide; and
- R.sub.3 is hydrogen or formyl;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1, where
- R.sub.1 and R.sub.3 have the meanings defined in claim 1, and
- R.sub.2 is thiomorpholino-1-oxide,
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 3. A compound of claim 2, where
- R.sub.1 and R.sub.2 have the meanings defined in claim 2, and
- R.sub.3 is hydrogen;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 4. A compound of claim 3, where
- R.sub.1 is benzylamino; N-benzylmethylamino; 2-phenylethylamino or 3-phenylpropylamino; and
- R.sub.2 and R.sub.3 have the meanings defined in claim 3;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 5. A compound of claim 3, which is 8-(N-methylbenzylamino)-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimido-[5,4-d]-pyrimidine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 6. A compound of claim 3, which is 8-benzylamino-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimido[5,4-d]-pyrimidine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 7. An antithrombotic pharmaceutical composition consisting essentially of an inert pharmaceutical carrier and an effective antithrombotic amount of a compound of claim 1.
- 8. The method of preventing or relieving thrombosis in a warm-blooded animal in need thereof, which comprises perorally, perenterally or rectally administering to said animal an effective antithrombotic amount of a compound of claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
2926804 |
Jul 1979 |
DEX |
|
3013930 |
Apr 1980 |
DEX |
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Parent Case Info
This is a division of Ser. No. 712,341, filed Mar. 15, 1985, now U.S. Pat. No. 4,690,923 which in turn is continuation of Ser. No. 575,322, filed Jan. 31, 1984, now abandoned; which in turn is a continuation-in-part of Ser. No. 350,429, filed Feb. 22, 1982, now abandoned; which in turn is a continuation of Ser. No. 161,010, filed June 19, 1980; now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3031450 |
Fischer et al. |
Apr 1962 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
209344 |
May 1960 |
ATX |
Divisions (1)
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Number |
Date |
Country |
Parent |
712341 |
Mar 1985 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
575322 |
Jan 1984 |
|
Parent |
161010 |
Jun 1980 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
350429 |
Feb 1982 |
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