Claims
- 1. A compound of the formula: ##STR141## where Z is: ##STR142## wherein: X is O or S(O).sub.0-2 ;
- R is H or CH.sub.3 ;
- R.sup.1 and R.sup.2 are independently H, CH.sub.3 --, CH.sub.3 CH.sub.2 --, (CH.sub.3).sub.2 CH--, HOCH.sub.2 --, CH.sub.3 CH(OH)--, (CH.sub.3).sub.2 C(OH)--, FCH.sub.2 CH(OH)--, F.sub.2 CHCH(OH)--, F.sub.3 CCH(OH)--, CH.sub.3 CH(F)--, CH.sub.3 CF.sub.2 --, or (CH.sub.3).sub.2 C(F)--;
- R.sup.a and R.sup.b are independently selected from the group consisting of hydrogen and the radicals set out below:
- (a) a trifluoromethyl group; --CF.sub.3 ;
- (b) a halogen atom: --Br, --Cl, --F, or --I;
- (c) C.sub.1 -C.sub.4 alkoxy radical; --OC.sub.1-4 alkyl, wherein the alkyl is optionally mono-substituted by R.sup.q, where
- R.sup.q is a member selected from the group consisting of --OH; --OCH.sub.3 ; --CN; --C(O)NH.sub.2 ; --OC(O)NH.sub.2 ; CHO; --OC(O)N(CH.sub.3).sub.2 ; --SO.sub.2 NH.sub.2 ; --SO.sub.2 N(CH.sub.3).sub.2 ; --SOCH.sub.3 ; SO.sub.2 CH.sub.3 ; --F; --CF.sub.3 ; --COOM.sup.a (where M.sup.a is hydrogen, alkali metal, methyl or phenyl); tetrazolyl (where the point of attachment is the carbon atom of the tetrazole ring and one of the nitrogen atoms is mono-substituted by M.sup.a as defined above); and --SO.sub.3 M.sup.b (where M.sup.b is hydrogen or an alkali metal);
- (d) a hydroxy group; --OH;
- (e) a carbonyloxy radical; ##STR143## where R.sup.s is C.sub.1-4 alkyl, phenyl, or heteroaryl, each of which is optionally mono-substituted by R.sup.q as defined above, and where heteroaryl is a monocyclic aromatic hydrocarbon group having 5 or 6 ring atoms in which one of the carbon atoms has been replaced by a nitrogen atom, one additional carbon atom is optionally replaced by a heteroatom selected from O and S, and from 1 to 3 additional carbon atoms are optionally replaced by a nitrogen heteroatom;
- (f) a carbamoyloxy radical; ##STR144## where R.sup.y and R.sup.z are independently H, C.sub.1-4 alkyl (optionally mono-substituted by R.sup.q as defined above), together a 3- to 5-membered alkylidene radical to form a ring (optionally substituted with R.sup.q as defined above), or together a 2- to 5-membered alkylidene radical, interrupted by --O--, --S--, --S(O)--, or --S(O).sub.2 --, to form a ring (optionally mono-substituted with R.sup.q as defined above);
- (g) a sulfur radical; ##STR145## where n=0-2, and R.sup.s is as defined above; (h) a sulfamoyl group; --SO.sub.2 N(R.sup.y)R.sup.z where R.sup.y and R.sup.z are as defined above;
- (i) azido; N.sub.3
- (j) a formylamino group: ##STR146## where R.sup.t is H or C.sub.1-4 alkyl, and the alkyl thereof is optionally mono-substituted by R.sup.q as defined above;
- (k) (C.sub.1 -C.sub.4 alkyl)carbonylamino radical: ##STR147## alkyl, where R.sup.t is as defined above, and the alkyl group is also optionally mono-substituted by R.sup.q as defined above;
- (l) a (C.sub.1 -C.sub.4 alkoxy) carbonylamino radical: ##STR148## alkyl, where R.sup.t is as defined above, and the alkyl group is also optionally mono-substituted by R.sup.q as defined above;
- (m) a ureido group: ##STR149## where R.sup.t, R.sup.y and R.sup.z are as defined above; (n) a sulfonamide group: ##STR150## where R.sup.s and R.sup.t are as defined above; (o) a cyano group: --CN;
- (p) a formyl or acetalized formyl radical: ##STR151## (q) (C.sub.1 -C.sub.4 alkyl)carbonyl radical wherein the carbonyl is acetalized: ##STR152## alkyl, where the alkyl is optionally mono-substituted by R.sup.q as defined above;
- (r) carbonyl radical: ##STR153## where R.sup.s is as defined above; (s) a hydroximinomethyl radical in which the oxygen or carbon atom is optionally substituted by a C.sub.1 -C.sub.4 alkyl group; ##STR154## where R.sup.y and R.sup.z are as defined above, except they may not be joined together to form a ring;
- (t) a (C.sub.1 -C.sub.4 alkoxy)carbonyl radical: ##STR155## alkyl, where the alkyl is optionally mono-substituted by R.sup.q as defined above;
- (u) a carbamoyl radical: ##STR156## where R.sup.y and R.sup.z are as defined above; (v) an N-hydroxycarbamoyl or N(C.sub.1 -C.sub.4 alkoxy)carbamoyl radical in which the nitrogen atom may be additionally substituted by a C.sub.1 -C.sub.4 alkyl group: ##STR157## where R.sup.y and R.sup.z are as defined above, except that they may not be joined together to form a ring;
- (w) a thiocarbamoyl group: ##STR158## where R.sup.y and R.sup.z are as defined above; (x) carboxyl; --COOM.sup.b, where M.sup.b is as defined above;
- (y) thiocyanate; --SCN;
- (z) trifluoromethylthio: --SCF.sub.3 ;
- (aa) tetrazolyl, where the point of attachment is the carbon atom of the tetrazole ring and one of the nitrogen atoms is mono-substituted by hydrogen, an alkali metal or a C.sub.1 -C.sub.4 alkyl optionally substituted by R.sup.q as defined above;
- (ab) an anionic function selected from the group consisting of: phosphone [P.dbd.O(OM.sup.b).sub.2 ]; alkylphosphono {P.dbd.O(OM.sup.b)--[O(C.sub.1 -C.sub.4 alkyl)]}; alkylphosphinyl [P.dbd.O(OM.sup.b)--(C.sub.1 -C.sub.4 alkyl)]; phosphoramido [P.dbd.O(OM.sup.b)N(R.sup.y)R.sup.z and P.dbd.O(OM.sup.b)NHR.sup.x ]; sulfino (SO.sub.2 MC.sup.b ; sulfo (SO.sub.3 M.sup.b); acylsulfonamides selected from the structures CONM.sup.b SO.sub.2 R.sup.x, CONM.sup.b SO.sub.2 N(R.sup.y)R.sup.z, SO.sub.2 NM.sup.b CON(R.sup.y)R.sup.z ; and SO.sub.2 NM.sup.b CN, where
- R.sup.x is phenyl or heteroaryl, where heteroaryl is as defined above under R.sup.s, and the phenyl and heteroaryl are optionally mono-substituted by R.sup.q, as defined above; M.sup.b, R.sup.y and R.sup.z are as defined above;
- (ac) C.sub.5 -C.sub.7 cycloalkyl group in which one of the carbon atoms in the ring is replaced by a heteroatom selected from O, S, NH, or N(C.sub.1 -C.sub.4 alkyl) and in which one additional carbon atom may be replaced by NH or N(C.sub.1 -C.sub.4 alkyl), and in which at least one carbon atom adjacent to each nitrogen heteroatom has both of its attached hydrogen atoms replaced by one oxygen thus forming a carbonyl moiety and there are at most two carbonyl moieties present in the ring;
- (ad) C.sub.2 -C.sub.4 alkenyl radical, optionally monosubstituted by one of (1) the substituents (a) to (ac) above; or (2) phenyl, pyridyl, quinoline, or isoquinoline, each of which is optionally monosubstituted by R.sup.q as defined above;
- (ae) C.sub.2 -C.sub.4 alkynyl radical, optionally monosubstituted by one of the substituents (a) to (ac) above;
- (af) C.sub.1 -C.sub.4 alkyl radical;
- (ag) C.sub.1 -C.sub.4 alkyl mono-substituted by one of the substituents (a)-(ac) above;
- (ah) a 2-oxazolidinonyl moiety in which the point of attachment is the nitrogen atom of the oxazolidinone ring, the ring oxygen atom is optionally replaced by a heteroatom selected from S and NR.sup.t (where R.sup.t is as defined above) and one of the saturated carbon atoms of the oxazolidinone ring is optionally mono-substituted by one of the substituents (a) to (ag) above;
- M is selected from:
- (i) hydrogen;
- (ii) a pharmaceutically acceptable esterifying group or removable carboxyl protecting group; or
- (iii) an alkali metal or other pharmaceutically acceptable cation.
- 2. A compound of claim 1 wherein R.sup.1 is (R)--CH.sub.3 CH(OH)-- or (R)--CH.sub.3 CH(F)--; and R and R.sup.2 are both H.
- 3. A compound of claim 2 wherein R.sup.1 is (R)--CH.sub.3 CH(OH)--.
- 4. A compound of claim 3 wherein Z is in the (A) configuration.
- 5. A compound of claim 1 wherein R.sup.a and R.sup.b are independently selected from the group consisting of: H, --CH.sub.3, --CH.sub.2 CH.sub.3, --(CH.sub.2).sub.3 CH.sub.3, --OCH.sub.3, --SCH.sub.3, tetrazolyl, --COOH, --CH.sub.2 CONH.sub.2, --CH.sub.2 CH.sub.2 SO.sub.3 H, --CONH.sub.2, --SO.sub.2 NH.sub.2, --SO.sub.3 H, --CON(CH.sub.3).sub.2, --CN, --CH.sub.2 CN, --CH.sub.2 SCH.sub.3, --CH.sub.2 SO.sub.3 H, --CH.sub.2 SOCH.sub.3, --CH.sub.2 SO.sub.2 CH.sub.3, --SO.sub.2 CH.sub.3, --SOCH.sub.3, --CH.sub.2 OCH.sub.3, --N.sub.3, --OCONH.sub.2, --OH, --CHO, --CH.sub.2 P(O)(OCH.sub.3)OH, --CF.sub.3, --CH.sub.2 OC(O)NH.sub.2, --CH.sub.2 SO.sub.2 NH.sub.2, --SCH.sub.2 CH.sub.2 CN, Br, Cl, F, --SCF.sub.3, --CH.sub.2 SCF.sub.3, --SCH.sub.2 CF.sub.3, --COCH.sub.3, --CH.dbd.NOH, --CONHOH, --C(S)NH.sub.2, --OCOCH.sub.3, --NHCOCH.sub.3, --NHCO.sub.2 CH.sub.3, --NHCONH.sub.2, --NHSO.sub.2 CH.sub.3, --SCN, --CH.dbd.CHCHO, --SCH.sub.2 CH.sub.2 OH, --CH.sub.2 OH, --CH.dbd.NOCH.sub.2 CO.sub.2 H, --CO.sub.2 CH.sub.2 CH.sub.2 OH, and --SO.sub.2 NHCH.sub.2 CONH.sub. 2.
- 6. A compound of claim 1 wherein the compound is:
- ______________________________________ ##STR159##No. M R' R X R.sup.a R.sup.b______________________________________ 4 K OH H S H H 5 K OH H SO H H 6 K OH H SO.sub.2 H H 7 K OH H O H H 19 K OH H O H 7-CH.sub.2 OH 34 K OH H O CONH.sub.2 H 40 K OH H O H 6-OH 43 K F H O H H 44 K OH H O SCH.sub.3 H 45 K OH H O S(O)CH.sub.3 H 46 K OH H O SO.sub.2 CH.sub.3 H 47 K OH H O SC.sub.2 H.sub.5 H 48 K OH H O SCH.sub.2 CH.sub.2 OH H 49 K OH H O S(O)CH.sub.2 CH.sub.2 OH H 50 K OH H O SO.sub.2 CH.sub.2 CH.sub.2 OH H 51 K OH H O CH.sub.2 OH H 52 K OH H O CHO H 53 K OH H O CHNOH H 54 K OH H O CN H 55 K OH H O CO.sub.2 K H 56 K OH H O CO.sub.2 CH.sub.3 H 57 K OH H O H 8-CH.sub.2 OH 58 K OH H O H 7-CHO 59 K OH H O H 7-CHNOH 60 K OH H O H 7-CN 61 K OH H O H 6-CH.sub.2 OH 62 K OH H S H 7-CN 63 K OH H S H 7-CH.sub.2 OH 64 K OH H SO H 7-CH.sub.2 OH 65 K OH H SO.sub.2 H 7-CH.sub.2 OH 66 K OH H S H 7-CHO 67 K OH H SO H 7-CHO 68 K OH H S H 7-CH.sub.2 N.sub.3 69 K OH H S CH.sub.2 OH H 70 K OH H SO CH.sub.2 OH H 71 K OH H SO.sub.2 CH.sub.2 OH H 72 K OH H S CHO H 73 K OH H SO CHO H 74 K OH H S CH(NOH) H 75 K OH H S CN H 76 K OH H S Cl H 77 K OH H SO Cl H 94 K OH H O CONHCH.sub.3 H 95 K OH H O CON(CH.sub.3).sub.2 H 98 K OH H O CONHCH.sub.2 CN H105 K OH H O H 6-CHO106 K OH H O H 8-CHO113 K OH H O H 7-CONH.sub.2161 K OH H S CONH.sub.2 H164 K OH H S H 7-CONH.sub.2209 K OH H SO CN H212 K OH H SO H 7-CN214 K OH H SO CONH.sub.2 H259 K OH H SO.sub.2 CHO H267 K OH H SO.sub.2 H 7-CN294 K OH H SO.sub.2 H 7-CHO302 K OH H SO H 7-CONH.sub.2312 K OH H O CONHCH.sub.2 CONH.sub.2 H315 K OH H O (E)CHCHCHO H324 K F H O CONH.sub.2 H325 K OH H O CONHCH.sub.2 CH.sub.2 OH H326 K OH H O CONHOCH.sub.3 H327 K OH H O H 7-CON(CH.sub.3).sub.2328 K OH H O H 7-COCH.sub.3329 K OH H S H 7-CO.sub.2 CH.sub.3330 K OH H SO H 7 CO.sub.2 CH.sub.3331 K OH H SO H 7-COCH.sub.3332 K F H O H 7-CH.sub.2 OH______________________________________
- ______________________________________ ##STR160##No. M R' R X R.sup.a R.sup.b______________________________________ 8 K OH H O H H 9 K OH H S H H78 K OH H O H 6-CH.sub.2 OH______________________________________
- 7. A compound of claim 1 wherein the compound is:
- __________________________________________________________________________ ##STR161##EXP.NO. M R' R X R.sup.a R.sup.b__________________________________________________________________________79 K OH H O F H80 K OH H O OH H81 K OH H O SCF.sub.3 H82 K OH H O CF.sub.3 H83 K OH H O NHCOCH.sub.3 H84 K OH H O NHSO.sub.2 CH.sub.3 H85 K OH H O SO.sub.3 K H86 K OH H O SO.sub.2 NH.sub.2 H87 K OH H O SO.sub.2 NHCN H88 K OH H O SO.sub.2 NHCONH.sub.2 H89 K OH H O PO.sub.3 KH H90 K OH H O COCH.sub.3 H91 K OH H O CHNOCH.sub.2 CO.sub.2 H H92 K OH H O ##STR162## H93 K OH H O CO.sub.2 CH.sub.2 CH.sub.2 OH H96 K OH H O CONHOH H97 K OH H O CONHCH.sub.2 CONH.sub.2 H99 K OH H O ##STR163## H100 K OH H O ##STR164## H101 K OH H O ##STR165## H102 K OH H O ##STR166## H103 K OH H O ##STR167## H104 K OH H O H 5-CHO107 K OH H O H 5-CN108 K OH H O H 6-CN109 K OH H O H 8-CN110 K F CH.sub.3 O CONH.sub.2 H111 K OH H O H 5-CONH.sub.2112 K OH H O H 6-CONH.sub.2114 K OH H O H 8-CONH.sub.2115 K OH H O F 7-CH.sub.2 OH116 K OH H O F 7-CHO117 K OH H O F 7-CONH.sub.2118 K OH H O F 7-CN119 K OH H O F 7-CO.sub.2 K120 K OH H O SOCH.sub.3 7-CHO121 K OH H O CN 7-SOCH.sub.3122 K OH H O CHO 7-SOCH.sub.3123 K OH H O CONH.sub.2 7-SOCH.sub.3124 K F H O CONH.sub.2 H125 K F H O CN H126 K F H O CHO H127 K OH CH.sub.3 O CONH.sub.2 H128 K OH CH.sub.3 O CN H129 K OH CH.sub.3 O CHO H130 K OH H S F H131 K OH H S OH H132 K OH H S SCF.sub.3 H133 K OH H S CF.sub.3 H134 K OH H S NHCOCH.sub.3 H135 K OH H S NHSO.sub.2 CH.sub.3 H136 K OH H S SO.sub.3 K H137 K OH H S SO.sub.2 NH.sub.2 H138 K OH H S SO.sub.2 NHCN H139 K OH H S SO.sub.2 NHCONH.sub.2 H140 K OH H S PO.sub.3 KH H141 K OH H S COCH.sub.3 H142 K OH H S CHNOCH.sub.2 CO.sub.2 H H143 K OH H S ##STR168## H144 K OH H S CO.sub.2 CH.sub.2 CH.sub.2 OH H145 K OH H S CONHCH.sub.3 H146 K OH H S CON(CH.sub.3).sub.2 H147 K OH H S CONHOH H148 K OH H S CONHCH.sub.2 CONH.sub.2 H149 K OH H S CONHCH.sub.2 CN H150 K OH H S ##STR169## H151 K OH H S ##STR170## H152 K OH H S ##STR171## H153 K OH H S ##STR172## H154 K OH H S ##STR173## H155 K OH H S H 5-CHO156 K OH H S H 6-CHO157 K OH H S H 8-CHO158 K OH H S H 5-CN159 K OH H S H 6-CN160 K OH H S H 8-CN162 K OH H S H 5-CONH.sub.2163 K OH H S H 6-CONH.sub.2165 K OH H S H 8-CONH.sub.2166 K OH H S F 7-CH.sub.2 OH167 K OH H S F 7-CHO168 K OH H S F 7-CONH.sub.2169 K OH H S F 7-CN170 K OH H S F 7-CO.sub.2 K171 K OH H S SOCH.sub.3 7-CHO172 K OH H S CN 7-SOCH.sub.3173 K OH H S CHO 7-SOCH.sub.3174 K OH H S CONH.sub.2 7-SOCH.sub.3175 K F H S CONH.sub.2 H176 K F H S CN H177 K F H S CHO H178 K OH CH.sub.3 S CONH.sub.2 H179 K OH CH.sub.3 S CN H180 K OH CH.sub.3 S CHO H181 K OH H SO F H182 K OH H SO OH H183 K OH H SO SCF.sub.3 H184 K OH H SO CF.sub.3 H185 K OH H SO NHCOCH.sub.3 H186 K OH H SO NHSO.sub.2 CH.sub.3 H187 K OH H SO SO.sub. 3 K H188 K OH H SO SO.sub.2 NH.sub.2 H189 K OH H SO SO.sub.2 NHCN H190 K OH H SO SO.sub.2 NHCONH.sub.2 H191 K OH H SO PO.sub.3 KH H192 K OH H SO COCH.sub.3 H193 K OH H SO CHNOCH.sub.2 CO.sub.2 H H194 K OH H SO ##STR174## H195 K OH H SO CO.sub.2 CH.sub.2 CH.sub.2 OH H196 K OH H SO CONHCH.sub.3 H197 K OH H SO CON(CH.sub.3).sub.2 H198 K OH H SO CONHOH H199 K OH H SO CONHCH.sub.2 CONH.sub.2 H200 K OH H SO CONHCH.sub.2 CN H201 K OH H SO ##STR175## H202 K OH H SO ##STR176## H203 K OH H SO ##STR177## H204 K OH H SO ##STR178## H205 K OH H SO ##STR179## H206 K OH H SO H 5-CHO207 K OH H SO H 6-CHO208 K OH H SO H 8-CHO210 K OH H SO H 5-CN211 K OH H SO H 6-CN213 K OH H SO H 8-CN215 K OH H SO H 5-CONH.sub.2216 K OH H SO H 6-CONH.sub.2217 K OH H SO H 7-CONH.sub.2218 K OH H SO H 8-CONH.sub.2219 K OH H SO F 7-CH.sub.2 OH220 K OH H SO F 7-CHO221 K OH H SO F 7-CONH.sub.2222 K OH H SO F 7-CN223 K OH H SO F 7-CO.sub.2 K224 K OH H SO SOCH.sub.3 7-CHO225 K OH H SO CN 7-SOCH.sub.3226 K OH H SO CHO 7-SOCH.sub.3227 K OH H SO CONH.sub.2 7-SOCH.sub.3228 K F H SO CONH.sub.2 H229 K F H SO CN H230 K F H SO CHO H231 K OH CH.sub.3 SO CONH.sub.2 H232 K OH CH.sub.3 SO CN H233 K OH CH.sub.3 SO CHO H234 K OH H SO.sub.2 F H235 K OH H SO.sub.2 OH H236 K OH H SO.sub.2 SF.sub.3 H237 K OH H SO.sub.2 CF.sub.3 H238 K OH H SO.sub.2 NHCOCH.sub.3 H239 K OH H SO.sub.2 NHSO.sub.2 CH.sub.3 H240 K OH H SO.sub.2 SO.sub.3 K H241 K OH H SO.sub.2 SO.sub.2 NH.sub.2 H242 K OH H SO.sub.2 SO.sub.2 NHCN H243 K OH H SO.sub.2 SO.sub.2 NHCONH.sub.2 H244 K OH H SO.sub.2 PO.sub.3 KH H245 K OH H SO.sub.2 COCH.sub.3 H246 K OH H SO.sub.2 CHNOCH.sub.2 CO.sub.2 H H247 K OH H SO.sub.2 ##STR180## H248 K OH H SO.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 OH H249 K OH H SO.sub.2 CONHCH.sub.3 H250 K OH H SO.sub.2 CON(CH.sub.3).sub.2 H251 K OH H SO.sub.2 CONHOH H252 K OH H SO.sub.2 CONHCH.sub.2 CONH.sub.2 H253 K OH H SO.sub.2 CONHCH.sub.2 CN H254 K OH H SO.sub.2 ##STR181## H255 K OH H SO.sub.2 ##STR182## H256 K OH H SO.sub.2 ##STR183## H257 K OH H SO.sub.2 ##STR184## H258 K OH H SO.sub.2 ##STR185## H260 K OH H SO.sub.2 H 5-CHO261 K OH H SO.sub.2 H 6-CHO262 K OH H SO.sub.2 H 7-CHO263 K OH H SO.sub.2 H 8-CHO264 K OH H SO.sub.2 CN H265 K OH H SO.sub.2 H 5-CN266 K OH H SO.sub.2 H 6-CN268 K OH H SO.sub.2 H 8-CN269 K OH H SO.sub.2 CONH.sub.2 H270 K OH H SO.sub.2 H CONH.sub.2271 K OH H SO.sub.2 H 6-CONH.sub.2272 K OH H SO.sub.2 H 7-CONH.sub.2273 K OH H SO.sub.2 H 8-CONH.sub.2274 K OH H SO.sub.2 F 7-CH.sub.2 OH274 K OH H SO.sub.2 F 7-CHO276 K OH H SO.sub.2 F 7-CONH.sub.2277 K OH H SO.sub.2 F 7-CN278 K OH H SO.sub.2 F 7-CO.sub.2 K279 K F H SO.sub.2 CONH.sub.2 H280 K F H SO.sub.2 CN H281 K F H SO.sub.2 CHO H282 K OH CH.sub.3 SO.sub.2 CONH.sub.2 H283 K OH CH.sub.3 SO.sub.2 CN H284 K OH CH.sub.3 SO.sub.2 CHO H__________________________________________________________________________
- 8. A pharmaceutical composition for antibacterial use comprising an antibacterially effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier therefor.
- 9. A method of treating bacterial infections in human or animal subjects in need of such treatment comprising administering to such subject an antibacterially effective amount of a compound of claim 1.
- 10. The combination of a compound of claim 1 and a DHP inhibitor.
- 11. The combination of a compound of claim 6 and the DHP inhibitor 7-(L-2-amino-2-carboxyethylthio)-2-(2,2-dimethylcyclopropanecarboxamide)-2-heptenoic acid.
- 12. A pharmaceutical composition for antibacterial use comprising an antibacterially effective amount of a compound of claim 1, an inhibitority effective amount of a DHP inhibitor, and, optionally, a pharmaceutically acceptable carrier therefor.
- 13. A pharmaceutical composition according to claim 12 wherein the DHP inhibitor is 7-(L-2-amino-2-carboxyethylthio)-2-(2,2-dimethylcyclopropanecarboxamide)-2-heptenoic acid.
- 14. A method of treating bacterial infections in human or animal subjects in need of such treatment comprising coadministering to such subject an antibacterially effective amount of a compound of claim 1 and an inhibitorily effective amount of a DHP inhibitor.
- 15. A method according to claim 14 wherein the DHP inhibitor is 7-(L-2-amino-2-carboxyethylthio)-2-(2,2-dimethylcyclopropanecarboxamide)-2-heptenoic acid.
CROSS-REFERENCE
This is a continuation-in-part of U.S. Ser. No. 376,193, June 30, 1989, which is a continuation of U.S. Ser. No. 362,916, June 8, 1989, now abandoned.
US Referenced Citations (3)
Foreign Referenced Citations (2)
Number |
Date |
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277243 |
Aug 1988 |
EPX |
291 |
Feb 1982 |
WOX |
Continuations (1)
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362916 |
Jun 1989 |
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Continuation in Parts (1)
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376193 |
Jun 1989 |
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