Claims
- 1. A 20-alkyl-7-oxoprostacyclin derivative of formula I ##STR10## wherein n is 1;
- R.sub.2 is a straight-chain or branched-chain C.sub.1-4 -alkyl group;
- m is 1; and
- R.sub.6 and R.sub.7 each independently are H or a straight-chain or branched-chain C.sub.1-4 -alkyl group;
- or a salt thereof with a physiologically compatible base.
- 2. A compound of claim 1, which is 16,20-dimethyl-7-oxo-18,18,19,19-tetradehydro-PGI.sub.2.
- 3. A pharmaceutical preparation comprising an effective amount of a compound of claim 1 and a pharmaceutically acceptable excipient.
- 4. A method of treating hypertension, comprising administering an effective amount of a compound of claim 1.
- 5. A method of inhibiting thrombocyte aggregation, comprising administering an effective amount of a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3340988 |
Nov 1983 |
DEX |
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Parent Case Info
This is a continuation of application Ser. No. 07/277,825, filed Nov. 30, 1988, which is a continuation of Ser. No. 07/144,139, filed Jan. 15, 1988, which is a continuation of Ser. No. 07/037,892, filed Apr. 13, 1987, which is a continuation of Ser. No. 06/917,444, filed Oct. 10, 1986, which is a continuation of Ser. No. 06/759,039, filed Jul. 10, 1985, all now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4364950 |
Shuballa et al. |
Dec 1982 |
|
4466969 |
Nicholson et al. |
Aug 1984 |
|
Non-Patent Literature Citations (1)
Entry |
van Dorp et al., Prostaglandins, vol. 16(6), pp. 953-956. |
Continuations (5)
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Number |
Date |
Country |
Parent |
277825 |
Nov 1988 |
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Parent |
144139 |
Jan 1988 |
|
Parent |
37892 |
Apr 1987 |
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Parent |
917444 |
Oct 1986 |
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Parent |
759039 |
Jul 1985 |
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