Claims
- 1. A compound having the structure n is 0; X is CN; Y is N or NH; Z is CH or CH2, with Z being CH2 when Y is NH, with Y—Z forming a single bond, and Z being CH when Y is N, with Y—Z forming a double bond; R1, R2, R3 and R4 are the same or different and are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, bicycloalkyl, bicycloalkylalkyl, alkylthioalkyl, arylalkylthioalkyl, cycloalkenyl, aryl, aralkyl; all optionally substituted through available carbon atoms with 1, 2, 3, 4 or 5 groups selected from hydrogen, halo, alkyl, polyhaloalkyl, alkoxy, haloalkoxy, polyhaloalkoxy, alkoxycarbonyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, polycycloalkyl, arylamino, hydroxy, hydroxyalkyl, nitro, cyano, amino, substituted amino, alkylamino, dialkylamino, thiol, alkylthio, alkylcarbonyl, acyl, alkoxycarbonyl, aminocarbonyl, alkynylaminocarbonyl, alkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyloxy, alkylcarbonylamino, arylcarbonylamino, alkylsulfonylamino, alkylaminocarbonylamino, alkoxycarbonylamino, alkylsulfonyl, aminosulfinyl, aminosulfonyl, alkylsulfinyl, sulfonamido or sulfonyl; and R1 and R3 may optionally be taken together to form —(CR5R6)m— where m is 2 to 6, and R5 and R6 are the same or different and are independently selected from hydroxy, alkoxy, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, alkylcarbonylamino, arylcarbonylamino, alkoxycarbonylamino, aryloxycarbonylamino, alkoxycarbonyl, aryloxycarbonyl, or alkylaminocarbonylamino, or R1 and R4 may optionally be taken together to form —(CR7R8)p— wherein p is 3 to 6, and R7 and R8 are the same or different and are independently selected from hydroxy, alkoxy, cyano, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, arylalkyl, alkylcarbonylamino, arylcarbonylamino, alkoxycarbonylamino, aryloxycarbonylamino, alkoxycarbonyl, aryloxycarbonyl, or alkylaminocarbonylamino, all stereoisomers thereof; and a pharmaceutically acceptable salt thereof.
- 2. The compound as defined in claim 1 having the structure
- 3. The compound as defined in claim 1 having the structure
- 4. The compound as defined in claim 1 having the structure
- 5. The compound as defined in claim 1 having the structure wherein R1 is H, alkyl, cycloalkyl or bicycloalkyl.
- 6. The compound as defined in claim 1 whereinR3 is H or alkyl, R1 is H, alkyl, cycloalkyl or bicycloalkyl, R2 is H or alkyl, n is 0, and X is CN.
- 7. The compound as defined in claim 1 wherein X is CN and has the configuration
- 8. The compound as defined in claim 1 having the structure
- 9. A pharmaceutical composition comprising a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Parent Case Info
This application claims priority to U.S. provisional application No. 60/283,438 filed Apr. 12, 2001, the entirety of which is incorporated herein by reference.
Non-Patent Literature Citations (2)
Entry |
Mish, M.R. et al, J. Am. Chem. Soc., 229, 8379-8380, (1997). |
Vasella, A. et al, Helvetica Chimica Acta, vol. 66, Fasc. 4, Nr. 121, 1241-1252, (1983). |
Provisional Applications (1)
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Number |
Date |
Country |
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60/283438 |
Apr 2001 |
US |