2,2-Difluoro-PGF.sub.2 analogs

Abstract

2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

Description

Claims

1. A compound of the formula ##STR1## or a mixture comprising that compound and the enantiomer thereof, wherein g is 2 to 4, inclusive;

wherein M.sub.4 is ##STR2## or ##STR3## wherein m is 2 to 4, inclusive, wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro, alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation, ##STR4##

2. A compound according to claim 1, wherein M.sub.4 is ##STR5##

3. A compound according to claim 2, wherein g is 2.

4. A compound according to claim 3, wherein m is 3.

5. 2,2,16,16-Tetrafluoro-PGF.sub.2 .alpha., a compound according to claim 4, wherein R.sub.1 is hydrogen.

6. 2,2,16,16-Tetrafluoro-PGF.sub.2 .alpha., methyl ester, a compound according to claim 4, wherein R.sub.1 is methyl.