Claims
- 1. A 2,3-Dihydro-1H-indene compound or salt thereof represented by the formula (1) ##STR178## wherein R.sup.1 and R.sup.2 are each a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, an unsubstituted phenyl group, a substituted phenyl group having 1 to 3 substituents selected from the group consisting of a halogen atom and a C.sub.1 -C.sub.6 alkyl group on the phenyl ring, an unsubstituted C.sub.3 -C.sub.8 cycloalkyl group, a substituted C.sub.3 -C.sub.8 cycloalkyl group having 1 to 3 halogen atoms as the substitutent on the cycloalkyl ring, a C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 --C.sub.6 alkyl group, a hydroxyl group, a phenyl-C.sub.1 -C.sub.6 alkoxy group, an unsubstituted phenyl-C.sub.1 -C.sub.6 alkyl group, a substituted phenyl-C.sub.1 -C.sub.6 alkyl group having 1 to 3 substituents selected from the group consisting of a halogen atom and a C.sub.1 -C.sub.6 alkoxy group on the phenyl ring or a substituted phenyl-C.sub.1 -C.sub.6 alkyl group having a C.sub.1 -C.sub.4 alkylenedioxy group on the phenyl ring;
- R.sup.3 is a halogen atom or a C.sub.1 -C.sub.6 alkyl group;
- R.sup.4 is a hydrogen atom, a halogen atom, a phenyl-C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl group, a piperidinyl-C.sub.1 -C.sub.6 alkanoylamino-C.sub.1 -C.sub.6 alkyl group, a pyridinium-C.sub.2 -C.sub.6 alkanoylamino-C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkyl group, a 1-phenyl-2-propenyl group, a 1-methyl-2-propenyl group, or a 2 chlorobenzoyl group;
- R.sup.5 is a group of the formula --NH--A--B, wherein A is a C.sub.1 -C.sub.6 alkylene group which may have at least one hydroxy group as the substituent, a group of the formula --CO--(D).sub.l -- or a group of the formula --D--CO--, wherein D is a C.sub.1 -C.sub.6 alkylene group and l is an integer of 0 or 1 and B is a 1-piperazinyl group which may have at least one substitutent selected from the group consisting of a C.sub.1 -C.sub.6 alkyl group which may have at least one hydroxy group as the substitutent, an oxo group, a carboxy group, a C.sub.1 -C.sub.6 alkoxycarbonyl group, a pyridyl group, a phthalimido group, a pyrrolidinylcarbonyl- C.sub.1 -C.sub.6 alkyl group, an unsubstituted phenyl group, a substituted phenyl group having 1 to 3 substituents selected from the group consisting of a halogen atom, a C.sub.1 -C.sub.6 alkyl group which may have 1 to 3 halogen atoms as subsitutents, a C.sub.1 -C.sub.6 alkoxy group and a nitro group on the phenyl ring, a phenyl-C.sub.1 -C.sub.6 alkyl group and a benzoyl group which may have 1 to 3 C.sub.1 -C.sub.6 alkoxy groups as the substituents on the phenyl ring;
- R.sup.6 is a hydrogen atom or a phenyl group; and
- R.sup.7 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group.
- 2. The 2,3-dihydro-1H-indene compounds of claim 1, wherein A is a group of the formula --CO--(D).sub.l.
- 3. The 2,3-dihydro-1H-indene compounds of claim 1, wherein A is a group of the formula --D--CO--.
- 4. The 2,3-dihydro-1H-indene compounds of claim 2, wherein R.sup.1 and R.sup.2 are each a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group.
- 5. The 2,3-dihydro-1H-indene compounds of claim 2, wherein R.sup.1 and R.sup.2 are each an unsubstituted phenyl group, a substituted phenyl group having 1 to 3 substituents selected from the group consisting of a halogen atom and a C.sub.1 -C.sub.6 alkyl group on the phenyl ring, an unsubstituted C.sub.3 -C.sub.8 cycloalkyl group, a saturated C.sub.3 -C.sub.8 cyclalkyl group having 1 to 3 halogen atoms as the substitutent on the cycloalkyl ring, a C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl group, a hydroxy group, a phenyl-C.sub.1 -C.sub.6 alkoxy group, an unsubstituted phenyl-C.sub.1 -C.sub.6 alkyl group or a substituted phenyl-C.sub.1 -C.sub.6 alkyl group having 1 to 3 substituents selected from the group consisting of a halogen atom, and a C.sub.1 --C.sub.6 alkoxy group on the phenyl ring or a substituted phenyl-C.sub.1 --C.sub.6 alkyl group having a C.sub.1 -C.sub.4 alkylenedioxy group on the phenyl ring.
- 6. The 2,3-dihydro-1H-indene compounds of claim 1, wherein R.sup.6 and R.sup.7 are each a hydrogen atom.
- 7. The 2,3-dihydro-1H-indene compounds of claim 6, wherein R.sup.3 and R.sup.4 are each a C.sub.1 -C.sub.6 alkyl group.
- 8. 2,3-Dihydro-1-[4-(3-methoxyphenyl)-1-piperzinyl]acetylamino-2,2,4,6-tetramethyl-7-hydroxy-1H-indene.
- 9. A pharmaceutical composition for improving anoxemic and hypoxic symptoms and syndromes accompanied therewith comprising a pharmaceutically effective amount of a 2,3-dihydro-1H-indene compound or a pharamaceutically acceptable salt thereof of claim 1.
- 10. An antioxidizing composition consisting essentially of a 2,3-dihydro-1H-indene compound or a pharmaceutically acceptable salt thereof of claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
59-183514 |
Aug 1984 |
JPX |
|
60-179191 |
Aug 1985 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 770,677 filed Aug. 29, 1985, now U.S. Pat. No. 4,788,130.
Non-Patent Literature Citations (1)
Entry |
Oshiro et al, CA 105-42509q (1986). |
Divisions (1)
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Number |
Date |
Country |
Parent |
770677 |
Aug 1985 |
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