Claims
- 1. A compound of general formula (1):
- 2. The compound of claim 1, wherein R1 represents a hydrogen atom or an optionally substituted acyl group containing 1 to 7 carbon atoms, and R5 and R6 combine to form a cycloalkyl group containing 3 to 8 carbon atoms or a saturated 5-12 membered heterocyclic group containing 1 to 3 oxygen atoms or sulfur atoms.
- 3. The compound of claim 2, wherein R1 represents a hydrogen atom.
- 4. The compound of claim 1, which is represented by general formula (2):
- 5. The compound of claim 4, wherein R1 represents a hydrogen atom or an optionally substituted acyl group containing 1 to 7 carbon atoms, and R5 and R6 combine to form a cycloalkyl group containing 3 to 8 carbon atoms or a saturated 5-12 membered heterocyclic group containing 1 to 3 oxygen atoms or sulfur atoms.
- 6. The compound of claim 5, wherein R1 represents a hydrogen atom.
- 7. The compound of claim 1, which is represented by general formula (3)
- 8. The compound of claim 7, wherein R1 represents a hydrogen atom or an optionally substituted acyl group containing 1 to 7 carbon atoms, and R5 and R6 combine to form a cycloalkyl group containing 3 to 8 carbon atoms or a saturated 5-12 membered heterocyclic group containing 1 to 3 oxygen atoms or sulfur atoms.
- 9. The compound of claim 8, wherein R1 represents a hydrogen atom.
- 10. A method of treating renal diseases comprising administering to a patient having a renal disease an effective amount of a compound of the formula (1):
- 11. The method in accordance with claim 10, wherein, in said compound of formula (1), R1 represents a hydrogen atom or an optionally substituted acyl group containing 1 to 7 carbon atoms, and R5 and R6 combine to form a cycloalkyl group containing 3 to 8 carbon atoms or a saturated 5-12 membered heterocyclic group containing 1 to 3 oxygen atoms or sulfur atoms.
- 12. The method in accordance with claim 10, wherein the renal disease is selected from the group consisting of chronic renal failure, diabetic nephrosis, glomerular nephritis, immunocomplex nephritis, acute renal failure, nephropathies caused by platinum complex-based anticancer agents, such as cisplatin or other drugs such as gentamicin, nephropathies caused by agrochemicals, such as Paracort, and uremia.
- 13. A method of preserving organs comprising storing an organ in an organ preservative containing an effective amount of a compound of general formula (1):
- 14. The method in accordance with claim 13, wherein, in said compound of formula (1), R1 represents a hydrogen atom or an optionally substituted acyl group containing 1 to 7 carbon atoms, and R5 and R6 combine to form a cycloalkyl group containing 3 to 8 carbon atoms or a saturated 5-12 membered heterocyclic group containing 1 to 3 oxygen atoms or sulfur atoms.
- 15. The method in accordance with claim 13, wherein the organ to be preserved is kidney.
- 16. The method in accordance with claim 13, wherein said compound is dissolved in said maintenance solution at a concentration of 0.1 10,000 mg/L.
Priority Claims (1)
Number |
Date |
Country |
Kind |
170889/1997 |
May 1997 |
JP |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a division of U.S. application Ser. No. 09/424,456, filed Nov. 23, 1999, which is a §371 of international application PCT/JP98/02248, filed May 22, 1998, both of which are herein incorporated by reference.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09424456 |
Nov 1999 |
US |
Child |
10121663 |
Apr 2002 |
US |