2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers, process for preparing same and perfumery uses thereof

BACKGROUND OF THE INVENTION
The present invention relates to 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers defined according to the structure: ##STR5## wherein R' represents methyl or ethyl and wherein R.sub.1 and R.sub.2 taken alone are the same or different hydrogen, phenyl, C.sub.1 -C.sub.8 alkyl or C.sub.2 -C.sub.8 alkenyl (with the proviso that R.sub.1 and R.sub.2 are not both hydrogen) and R.sub.1 and R.sub.2 taken together represent C.sub.5 -C.sub.12 cycloalkyl or alkyl cycloalkyl, and reaction products containing same as well as uses thereof in order to alter, modify or enhance the aroma of consumable materials.
There has been considerable work performed relating to substances which can be used to impart (alter, modify or enhance) fragrances to (or in) various consumable materials. These substances are used to diminish the use of natural materials some of which may be in short supply and to provide more uniform properties in the finished product.
Green, herbaceous, basil, parsley, rose, fruity, mandarin orange peel, spicy, earthy, rooty, sauge sclaree, minty, woody, celery-like, citrusy, seashore, fresh, clean, ozoney, tangerine-like, grapefruit-like, Nootkatone-like, jasmine, dill, caraway, nutty, coconut, floral, peach-like, apricot-like, caramel-like, maple syrup and new mown hay aromas, with galbanum, jasmine, celery-like, green, pineapple, cinnamon, pineapple, oak moss, almond oil, animalic, herbaceous, camphoraceous and eucalyptus-like topnotes, and fruity, floral, jasmine, lily of the valley, green, herbaceous, animalic, dill, caraway, citrusy, sweet citrus, straw-like and bergamot undertones are highly desirable in several types of perfume compositions, perfumed articles and colognes.
The perfume use of 2,4-disubstituted tetrahydropyranols having the structures: ##STR6## is disclosed in the literature as follows:
(a) the perfume use of the compound having the structure: ##STR7## USSR Patent 620487 of July 17, 1978 (Chemical Abstracts 89: 185929p);
(b) the compound having the structure: ##STR8## USSR Patent 638597 of Dec. 28, 1978 (Chemical Abstracts, Volume 90: 109812a);
(c) the compound having the structure: ##STR9## USSR Patent 618374 of Aug. 5, 1978 (Chemical Abstracts 89: 179861u).
The perfumery uses of compounds defined according to the generic structure: ##STR10## wherein R.sub.1 ' and R.sub.2 ' are defined, supra, including compounds of the subgenuses: ##STR11## is well known in the prior art. Thus, for example, U.S. Letters Patent 3,681,263 (Van der Linde, et al) discloses the use of the compounds having the structures: ##STR12## in perfumery (mixtures wherein in the mixtures in each of the compounds one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds) using as an intermediate to form such compounds the compound having the structure: ##STR13## Van der Linde, et al also discloses the perfumery use of the compound having the structure: ##STR14## and the synthesis process, to wit: ##STR15##
Hall, et al, U.S. Letters Patent 4,240,447 discloses the genus of compounds defined according to the structure: ##STR16## for use in perfumery wherein the moieties R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 may be hydrogen or alkyl and one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines are carbon-carbon single bonds in each of the compounds disclosed.
Netherlands Published Patent Application 68/08496 discloses the genus of compounds defined according to the structure: ##STR17## wherein A completes a cycloalkyl moiety and the moieties R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13 and R.sub.14 represent hydrogen or alkyl . . . including the compound having the structure: ##STR18## (formula 15).
Vinals, et al, U.S. Letters Patent 4,070,491, at columns 15 and 16, discloses the organoleptic uses of the compound having the structure: ##STR19## wherein one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Nothing in the prior art discloses the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention for their organoleptic utilities.
In addition, the prior art discloses synthetic routes to the genus of compounds having the structure: ##STR20## to wit: Chem. Abstracts Volume 101: 54857g disclosing the genus of compounds having the structure: ##STR21## wherein R.sub.3 and R.sub.4 represent alkyl, hydrogen, phenyl, vinyl, cyclohexyl and cyclopentyl; Chem. Abstracts Volume 87: 5757h disclosing the synthesis route: ##STR22## Chem. Abstracts Volume 101: 54857 disclosing the synthesis route: ##STR23## Chem. Abstracts Volume 94: 47139h disclosing the synthesis route: ##STR24##
Nothing in the prior art shows synthesis routes which will effect production of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention.

BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is the GLC profile for the reaction product of Example I containing compounds having the structures: ##STR25## wherein the compounds having the structure: ##STR26## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 180.degree. C. isothermal).
FIG. 2 is the NMR spectrum for the compound having the structure: ##STR27## fraction 11 of the distillation product of the reaction product of Example I.
FIG. 3 is the GLC profile for the reaction product of Example II containing the compounds having the structures: ##STR28## wherein in the compounds having the structure: ##STR29## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines are carbon-carbon single bonds (Conditions: SE-30 column programmed at 180.degree. C. isothermal).
FIG. 4 is the NMR spectrum for the peaks indicated by reference numerals 31 and 32 of the GLC profile of FIG. 3; for the compound having the structure: ##STR30##
FIG. 5 is the GLC profile for the reaction product of Example III containing the compounds having the structures: ##STR31## wherein in the compounds having the structure: ##STR32## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 120.degree. C. isothermal).
FIG. 6 is the NMR spectrum for Fraction 14 of the distillation product of the reaction product of Example III which is for the compound having the structure: ##STR33##
FIG. 7 is the NMR spectrum for Fraction 11 of the distillation product of the reaction product of Example III which is for the compound having the structure: ##STR34##
FIG. 8 is the GLC profile for the reaction product of Example IV containing the compounds having the structures: ##STR35## wherein in the compounds having the structure: ##STR36## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 120.degree. C. isothermal).
FIG. 9 is the NMR spectrum for the peaks indicated by reference numerals 81 and 82 of the GLC profile of FIG. 8 for the compound having the structure: ##STR37##
FIG. 10 is the GLC profile for the reaction product of Example V containing the compounds having the structures: ##STR38## wherein in the compounds having the structure: ##STR39## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 11 is the NMR spectrum for peak 103 of the GLC profile of FIG. 10 for the compound having the structure: ##STR40## prepared according to Example V.
FIG. 12 is the GLC profile for the reaction product of Example VI containing the compounds having the structures: ##STR41## wherein in the compounds having the structure: ##STR42## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 120.degree. C. isothermal).
FIG. 13 is the NMR spectrum for Fraction 14 of the distillation product of the reaction product of Example VI which is for the compound having the structure: ##STR43##
FIG. 14 is the GLC profile for the reaction product of Example VII containing the compounds having the structures: ##STR44## wherein in the compounds having the structure: ##STR45## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 180.degree. C. isothermal).
FIG. 15 is the NMR spectrum for the peak indicated by reference numerals 140 and 141 of the GLC profile of FIG. 14 for the compound having the structure: ##STR46##
FIG. 16 is the GLC profile for the reaction product of Example VIII containing the compounds having the structures: ##STR47## wherein in the compounds having the structure: ##STR48## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 160.degree. C. isothermal).
FIG. 17 is the NMR spectrum for the peaks indicated by reference numerals 160 and 161 of the GLC profile of FIG. 16 for the compound having the structure: ##STR49##
FIG. 18 is the GLC profile for the reaction product of Example IX containing the compounds having the structures: ##STR50## wherein in the compounds having the structure: ##STR51## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 19 is the NMR spectrum for the peaks indicated by reference numerals 180 and 181 of the GLC profile of FIG. 18 for the compound having the structure: ##STR52## prepared according to Example IX.
FIG. 20 is the GLC profile for the reaction product of Example X containing the compounds having the structures: ##STR53## wherein in the compounds having the structure: ##STR54## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 21 is the NMR spectrum for Fraction 14 of the distillation product of the reaction product of Example X and is for the compound having the structure: ##STR55##
FIG. 22 is the GLC profile for the reaction product of Example XI containing the compounds having the structures: ##STR56## wherein in the compounds having the structure: ##STR57## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 23 is the NMR spectrum for the peaks indicated by reference numerals 2202, 2203 and 2204 of the GLC profile of FIG. 22 for the mixture of compounds having the structure: ##STR58## wherein in the mixture of compounds having the structure: ##STR59## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 24 is the NMR spectrum for the peaks indicated by reference numerals 2201 and 2200 of the GLC profile of FIG. 22 for the compound having the structure: ##STR60##
FIG. 25 is the GLC profile for the reaction product of Example XII for the compounds having the structures: ##STR61## wherein in the compounds having the structure: ##STR62## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 160.degree. C. isothermal).
FIG. 26 is the NMR spectrum for the peaks indicated by reference numerals 2500 and 2501 of the GLC profile of FIG. 25 for the compound having the structure: ##STR63##
FIG. 27 is the GLC profile for the reaction product of Example XIII containing the compounds having the structures: ##STR64## wherein in the compounds having the structure: ##STR65## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: Carbowax column programmed at 120.degree. C. isothermal).
FIG. 28 is the NMR spectrum for the peaks indicated by reference numerals 2700 and 2701 of the GLC profile of FIG. 27 for the compound having the structure: ##STR66##
FIG. 29 is the GLC profile for the reaction product of Example XIV containing the compounds having the structures: ##STR67## wherein in the compounds having the structure: ##STR68## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 200.degree. C. isothermal).
FIG. 30 is the NMR spectrum for Fraction 9 of the distillation product of the reaction product of Example XIV which is for the compound having the structure: ##STR69##
FIG. 31 is the GLC profile for the reaction product of Example XV containing the compounds having the structures: ##STR70## wherein in the compounds having the structure: ##STR71## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 32 is the NMR spectrum for the peaks indicated by reference numerals 312, 313 and 314 of the GLC profile of FIG. 31 for the compounds having the structure: ##STR72## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines is a carbon-carbon single bond.
FIG. 33 is the NMR spectrum for peaks 310 and 311 of the GLC profile of FIG. 31 for the compound having the structure: R1 ? ##STR73## prepared according to Example XV.
FIG. 34 is the GLC profile for the reaction product of Example XVI containing the compounds having the structures: ##STR74## wherein in the compounds having the structure: ##STR75## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 35 is the NMR spectrum for the peaks indicated by reference numerals 340 and 341 of the GLC profile of FIG. 34 for the compound having the structure: ##STR76## prepared according to Example XVI.
FIG. 36 is the NMR spectrum for the peaks indicated by reference numerals 342 and 343 of the GLC profile of FIG. 34 for the mixture of compounds defined according to the structure: ##STR77## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 37 is the GLC profile for the reaction product of Example XVII containing the compounds having the structures: ##STR78## wherein in the compounds having the structures: ##STR79## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 38 is the NMR spectrum for Fraction 11 of the distillation product of the reaction product of Example XVII containing the compound having the structure: ##STR80##
FIG. 39 is the NMR spectrum for Fraction 5 of the distillation product of the reaction product of Example XVII containing the mixture of compounds having the structure: ##STR81## wherein in the mixture in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 40 is the GLC profile for the reaction product of Example XVIII containing the compounds having the structures: ##STR82## wherein in the compounds having the structure: ##STR83## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 41 is the NMR spectrum for peaks 400 and 401 of the GLC profile of FIG. 40 for the compound having the structure: ##STR84## prepared according to Example XVIII.
FIG. 42 is the NMR spectrum for the peaks indicated by reference numerals 402, 403 and 404 of the GLC profile of FIG. 40 for the compounds having the structure: ##STR85## wherein in each of the compounds of the mixture one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represents a carbon-carbon single bond.
FIG. 43 is a GLC profile for the reaction product of Example XIX containing the compounds having the structures: ##STR86## wherein in the compounds having the structure: ##STR87## in each of the compounds of the mixture one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 44 is the NMR spectrum for the peak indicated by reference numeral 430 of the GLC profile of FIG. 43 and is for the compound having the structure: ##STR88## prepared according Example XIX.
FIG. 45 is the GLC profile for the reaction product of Example XX containing the compounds having the structures: ##STR89## wherein in the compounds have the structure: ##STR90## one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds (Conditions: SE-30 column programmed at 200.degree. C. isothermal).
FIG. 46 is the NMR spectrum for the peaks indicated by reference numerals 450, 451 and 452 of the GLC profile of FIG. 45 for the mixture of compounds having the structure: ##STR91## wherein in the mixture in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 47 represents a cut-away side elevation view of apparatus used in forming perfumed polymers which contain imbedded therein at least one of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention.
FIG. 48 is a front view of the apparatus of FIG. 47 looking in the direction of the arrows.

DETAILED DESCRIPTION OF THE DRAWINGS
FIG. 1 is the GLC profile for the reaction product of Example I. The peaks indicated by reference numerals 10 and 11 are the peaks for the compound having the structure: ##STR92## The peaks indicated by reference numerals 12, 13 and 14 are the peaks for the compounds defined according to the generic structure: ##STR93## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 3 is the GLC profile for the reaction product of Example II. The peaks indicated by reference numerals 31 and 32 are for the compound having the structure: ##STR94## The peaks indicated by reference numerals 33, 34 and 35 are for compounds defined according to the generic structure: ##STR95## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 5 is the GLC profile for the reaction product of Example III. The peaks indicated by reference numerals 51 and 52 are for the compound having the structure: ##STR96## The peaks indicated by reference numerals 53, 54 and 55 are for the compounds represented by the generic structure: ##STR97## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 8 is the GLC profile for the reaction product of Example IV. The peaks indicated by reference numerals 81 and 82 are for the compound having the structure: ##STR98## The peaks indicated by reference numerals 83, 84 and 85 are for the compounds defined according to the generic structure: ##STR99## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 10 is the GLC profile for the reaction product of Example V. The peak indicated by reference numeral 103 is for the compound having the structure: ##STR100## The peaks indicated by reference numerals 100, 101 and 102 are for the compounds defined according to the generic structure: ##STR101## wherein in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 12 is the GLC profile of the reaction product of Example VI. The peaks indicated by reference numerals 121 and 122 are for the compound having the structure: ##STR102## The peaks indicated by reference numerals 123, 124 and 125 are for the compounds of the genus of compounds having the structure: ##STR103## wherein in each of the compounds one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 14 is the GLC profile for the reaction product of Example VII. The peaks indicated by reference numerals 140 and 141 are for the compound having the structure: ##STR104## The peaks indicated by reference numerals 142, 143 and 144 are for the members of the genus having the structure: ##STR105## wherein in each of the compounds of the genus one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 16 is a GLC profile for the reaction product of Example VIII. The peaks indicated by reference numerals 160 and 161 are for the compound having the structure: ##STR106##
FIG. 18 is the GLC profile for the reaction product of Example IX. The peaks indicated by reference numerals 180 and 181 are for the compound having the structure: ##STR107## The peaks indicated by reference numerals 182, 183 and 184 are for the members of the genus of compounds having the structure: ##STR108## wherein in each of the compounds one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 20 is the GLC profile for the reaction product of Example X. The peaks indicated by reference numerals 200 and 201 are for the compound having the structure: ##STR109## The peaks indicated by reference numerals 202, 203 and 204 are for the members of the genus of compounds having the structure: ##STR110## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 22 is the GLC profile for the reaction product of Example XI. The peaks indicated by reference numerals 2201 and 2200 are for the compound having the structure: ##STR111## The peaks indicated by reference numerals 2202, 2203 and 2204 are for the members of the genus of compounds having the structure: ##STR112## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 25 is the GLC profile for the reaction product of Example XII. The peaks indicated by reference numerals 2500 and 2501 are for the compound having the structure: ##STR113## The peaks indicated by reference numerals 2502, 2503 and 2504 are for the members of the genus of compounds having the structure: ##STR114## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 27 is the GLC profile for the reaction product of Example XIII. The peaks indicated by reference numerals 2700 and 2701 are for the compound having the structure: ##STR115## The peaks indicated by reference numerals 2702, 2703 and 2704 are for the members of the genus of compounds having the structure: ##STR116## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 29 is the GLC profile for the reaction product of Example XIV. The peak indicated by reference numeral 290 is the peak for the compound having the structure: ##STR117##
The peaks indicated by reference numerals 291, 292 and 293 are for the compounds defined according to the genus having the structure: ##STR118## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 31 is the GLC profile for the reaction product of Example XV. The peaks represented by the numerals 310 and 311 are for the compound having the structure: ##STR119## The peaks represented by reference numerals 312, 313 and 314 are for the compounds defined according to the genus: ##STR120## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 34 is the GLC profile for the reaction product of Example XVI. The peaks indicated by reference numerals 340 and 341 are for the compound having the structure: ##STR121## The peaks indicated by reference numerals 342 and 343 are for the members of the genus of compounds having the structure: ##STR122## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and the other two of the dashed lines represent carbon-carbon single bonds.
FIG. 37 is the GLC profile for the reaction product of Example XVII. The peaks indicated by reference numerals 373 and 374 are for the compound having the structure: ##STR123## The peaks indicated by reference numerals 370, 371 and 372 are for the members of the genus of the compounds having the structure: ##STR124## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other two dashed lines represent carbon-carbon single bonds.
FIG. 40 is the GLC profile for the reaction product of Example XVIII. The peaks indicated by reference numerals 400 and 401 are for the compound having the structure: ##STR125## The peaks indicated by reference numerals 402, 403 and 404 are for the members of the genus of compounds having the structure: ##STR126## wherein in each of the compound is one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
FIG. 43 is the GLC profile for the reaction product of Example XIX. The peak indicated by reference numeral 430 is the peak for the compound having the structure: ##STR127## The peaks indicated by reference numerals 431 and 432 are for the members of the genus of compounds having the structure: ##STR128## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other two of the dashed lines represent carbon-carbon single bonds.
FIG. 45 is the GLC profile for the reaction product of Example XX. The peaks indicated by reference numerals 450, 451 and 452 are for the members of the genus of compounds having the structure: ##STR129## wherein in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represents a carbon-carbon signal bond.
Referring to FIGS. 47 and 48, there is provided a process for forming scented polymer elements (wherein the polymer may be a thermoplastic polymer such as low density polyethylene or polypropylene or copolymers of ethylene and vinyl acetate or mixtures of polymers and copolymers such as copolymers of ethylene and vinyl acetate and polyethylene) such as pellets useful in the formation of plastic particles useful in fabricating certain articles which ay be perfumed (and, further, which may be exposed to chlorine bleaches). This process comprises heating the polymer or mixture of polymers to the melting point of said polymer or mixture of polymers, e.g., 250.degree. C. in the case of low density polyethylene. The lower most portion of the container is maintained at a slightly lower temperature and the material in the container is taken off at such location for delivery through the conduit. Thus, referring to FIGS. 47 and 48, in particular, the apparatus used in producing such elements comprises a device for forming the polymer containing the perfume, e.g., polyethylene or polyethylene-polyvinyl acetate or mixtures of same or polyproylene, which comprises a vat or container 212 into which the polymer taken alone or in admixture with other copolymers and the perfuming substance which is at least one of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention and other compatible perfumes is placed. The container is closed by means of an air-tight lid 228 and clamped to the container by bolts 265. The stirrer 273 traverses the lid or cover 228 in an air-tight manner and is rotatable in a suitable manner. A surrounding cylinder 212A having heating coils which are supplied with electric current through cable 214 from a rheostat or control 216 is operated to maintain the temperature inside the container 212 such that the polymer in the container will be maintained in the molten or liquid state. It has been found advantageous to employ polymers at such a temperature that the viscosity will be in the range of 90-100 sayboldt seconds. The heater 218 is operated to maintain the upper portion of the container 212 within a temperature range of, for example, 220.degree.-270.degree. C. in the case of low density polyethylene.
The bottom portion of the container 212 is heated by means of heating coils 212A regulated through the control 220 connected thereto through a connecting wire 222 to maintain the lower portion of the container 212 within a temperature range of 220.degree.-270.degree. C.
Thus, the polymer or mixture of polymers added to the container 212 is heated from 10-12 hours, whereafter the perfume composition or perfume material which contains one or more of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention is quickly added to the melt. Generally, about 10-45 percent by weight of the resulting mixture of the perfumery substance is added to the polymer.
After the perfume material is added to the container 212, the mixturee is stirred for a few minutes, for example, 5-15 minutes and maintained within the temperature ranges indicated previously by the heating coil 212A. The controls 216 and 220 are connected through cables 224 and 226 to a suitable supply of electric current for supplying the power for heating purposes.
Thereafter, the valve "V" is opened permitting the mass to flow outwardly through conduit 232 having a multiplicity of orifices 234 adjacent to the lower side thereof. The outer end of the conduit 232 is closed so that the liquid polymer in intimate admixture with one or more of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention and one or more other substances, will continuously drop through the orifices 234 downwardly from the conduit 232. During this time, the temperature of the polymer intimately admixed with the perfumery substance in the container 212 is accurately controlled so that a temperature in the range of from about 240.degree.-250.degree. C., for example, (in the case of low density polyethylene) will exist in the conduit 232. The regulation of the temperature through the controls 216 and 220 is essential in order to insure temperature balance to provide for the continuous dripping or dropping of molten polymer intimately admixed with the perfume substance which is all of or which contains one or more of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention, through the orifices 234 at a rate which will insure the formation of droplets 236 which will fall downwardly onto a moving conveyor belt 238 caused to run between conveyor wheels 240 and 242 beneath the conduit 232.
When the droplets 236 fall onto the conveyor 238, they form pellets 244 which harden almost instantaneously and fall off the end of the conveyor 238 into a container 250 which is advantageously filled with water or some other suitable cooling liquid to insure the rapid cooling of each of the pellets 244. The pellets 244 are then collected from the container 250 and utilized for the formation of functional products, e.g., garbage bags and the like.
THE INVENTION
The present invention provides 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers defined according to the structure: ##STR130## wherein R' represents methyl or ethyl and R.sub.1 and R.sub.2 taken alone are the same or different hydrogen, phenyl, C.sub.1 -C.sub.8 alkyl or C.sub.2 -C.sub.8 alkenyl (with the proviso that R.sub.1 and R.sub.2 are not both hydrogen) and R.sub.1 and R.sub.2 taken together are a C.sub.5 -C.sub.12 cycloalkyl or alkyl cycloalkyl moiety. The present invention also provides mixtures of such 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers with compounds having the structure: ##STR131## wherein R.sub.1 ' and R.sub.2 ' are the same as R.sub.1 and R.sub.2 defined, supra, and the moiety: ##STR132## causes the structure: ##STR133## to represent a mixture wherein in the mixture, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines in each of the compounds of the mixture represents a carbon-carbon single bond.
The 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention may be produced according to three process steps:
(a) first reacting an aldehyde or a ketone with a reagent for effecting acetal or ketal formation according to the reaction: ##STR134##
(b) then reacting the thus-formed ketal or acetal with prenyl alcohol according to the reaction: ##STR135##
(c) the thus-formed prenyl acetal or ketal then rearranges to form a composition of matter containing the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention, thusly: ##STR136##
The mechanisms of the reaction whereby the prenyl alcohol is first reacted with the ketal or acetal and the resulting prenyl acetal or ketal is rearranged is as follows: ##STR137##
The aforementioned reaction between the prenyl alcohol and the acetal or ketal having the structure: ##STR138## and resultant rearrangement is carried in the presence of from about 1% up to about 5% by weight of the reaction mass of a protonic acid, preferably sulfuric acid. The mole ratio of prenyl alcohol having the structure: ##STR139## to acetal or ketal having the structure: ##STR140## is preferably about 1:1. The reaction temperature may range from about 50.degree. C. up to about 100.degree. C. with a preferred reaction temperature of about 80.degree. C.
At the end of the reaction, the reaction mass is fractionally distilled and, if desired, (from an organoleptic standpoint) the group of compounds having the structure: ##STR141## may be separated by means of distillation from the group of compounds having the structure: ##STR142##
An alternative route to form the compounds having the structure: ##STR143## is to react the corresponding alcohols with an etherifying reagent such as dimethyl sulfate according to the reaction: ##STR144##
The pyranol reactants for the foregoing reaction may be produced using conditions as set forth in the prior art, for example, conditions set forth in USSR Patent No. 620,487 by means of reacting an aldehyde or a ketone with prenyl alcohol according to the reaction: ##STR145## in the presence of an acid catalyst such as an inorganic acid or an acid anion exchange catalyst or phosphoric acid or sulfuric acid at a temperature in the range of from about 50 up to about 60.degree. C. Examples of such reactions in the prior art to form pyranols are as follows:
(a) the reaction: ##STR146## set forth in U.S.S.R. Patent 620,487;
(b) the reaction: ##STR147## set forth in U.S.S.R. Patent 638,597.
Specific examples of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers produced according to the foregoing processes and useful in the practice of our invention and their organoleptic properties are set forth in Table I below:
TABLE I______________________________________Structure of Compound Perfumery Evaluation______________________________________The compound having A green, herbaceous,the structure: parsley, rose, fruity, ##STR148## spicy, earthy and rooty aroma profileproduced accordingto Example I.The compound having A sauge sclaree, mintythe structure: and woody aroma. ##STR149##produced accordingto Example II. The compound having A fruity, herbaceous,the structure: celery-like, citrusy ##STR150## aroma with fruity, floral, jasmine, lily of the valley, green and herbaceous undertones.produced accordingto Example III.The compound having A fresh, clean, tange-the structure: ine-like, fruity, ##STR151## jasmine aroma with galbanum, jasmine, celery-like, green and pineapple topnotes.produced accordingto Example IV.The compound having A green, herbaceous,the structure woody, aroma with ##STR152## floral undertones.produced accordingto Example V.The compound having A spicy, dill, caraway,the structure herbaceous aroma ##STR153## animalic, dill and caraway undertones.produced accordingto Example VI.The compound having A nutty, coconutthe structure: aroma with cinnamon ##STR154## and pineapple topnotes and floral, herbaceous undertones.produced accordingto Example VII.The compound having A spicy aroma withthe structure oak moss topnotes ##STR155##produced accordingto Example VIII.The compound having A fruity, herbaceous,the structure: floral aroma with ##STR156## citrusy, herbaceous and floral undertones.produced accordingto Example IX.The compound having A fruity, peach andthe structure: coconut-like aroma ##STR157## with almond oil topnotes.produced accordingto Example X.The compound having A fresh, ozoney,the structure: seashore, aroma with ##STR158## animalic topnotes.produced accordingto Example XI.The compound having A caramel, maplethe structure: syrup aroma with ##STR159## green, herbaceous topnotes.produced accordingto Example XII.The compound having A minty, woody,the structure: green, herbaceous ##STR160## aroma with camphoraceous, eucalyptus-like topnotes. .produced accordingto Example XIII.The compound having A citrusy, grapefruit,the structure: nootkatone-like ##STR161## aromaproduced accordingto Example XIV.The compound having A green, herbaceous,the structure: aroma with animalic ##STR162## undertones.produced accordingto Example XV.The compound having A new moun haythe structure: aroma with green, ##STR163## herbaceous, straw- like undertones.produced accordingto Example XVI.The compound having A jasmine aroma.the structure: ##STR164##produced accordingto Example XVII.The compound having A fruity, peach-like,the structure: apricot and jasmine ##STR165## aroma profile.produced accordingto Example XVIII.The compound having A woody, citrusy,the structure: mandarine orange ##STR166## peel-like, floral, herbaceous and basil aroma with sweet citrus, bergamot and floral undertones.produced accordingto Example XIX.The compound having A herbaceous, plumthe structure: aroma with fresh, ##STR167## ozoney undertones.prepared accordingto Example XX.______________________________________
The 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention and one or more auxiliary perfume ingredients, including, for example, hydrocarbons, alcohols, ketones, aldehydes, nitriles, esters lactones, ethers other than the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention, hydrocarbons, synthetic essential oils and natural essential oils may be admixed so that the combined odors of the individual components produce a pleasant and desired fragrance, particularly and preferably in the citrusy and/or herbaceous and/or woody and/or piney and/or earthy fragrances.
Such perfume compositions usually contain (a) the main note or the "bouquet" or foundation stone of the composition; (b) modifiers which round off and accompany the main note; (c) fixatives which include odorous substances which lend a particular note to the perfume throughout all stages of evaporation and substances which retard evaporation; and (d) topnotes which are usually low boiling fresh smelling materials.
In perfume compositions, it is the individual components which contribute to their particular olfactory characteristics; however the overall sensory effect of the perfume composition will be at least the sum total of the effects of each of the ingredients. Thus, one or more of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention can be used to alter, modify or enhance the aroma characteristics of a perfume composition, for example, by utilizing or moderating the olfactory reaction contributed by another ingredient in the composition.
The amount of one or more of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention which will be effective in perfume compositions as well as in perfumed articles and colognes depends upon many factors, including the other ingredients, their amounts and the effects which are desired. It has been found that perfume compositions containing as little as 0.005% of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention or even less (e.g., 0.002%) can be used to impart, augment or enhance green, herbaceous, basil, parsley, rose, fruity, mandarin orange peel, spicy, earthy, rooty, sauge sclaree, minty, woody, celery-like, citrusy, seashore, fresh, clean, ozoney, tangerine-like, grapefruit-like, Nootkatone-like, jasmine, dill, caraway, nutty, coconut, floral, peach-like, apricot-like, caramel-like, maple syrup and new moun hay aroma profiles with galbanum, jasmine, celery-like, green, cinnamon, pineapple, oak moss, almond oil, animalic, herbaceous, camphoraceous and eucalyptus-like topnotes and fruity, floral, jasmine, lily of the valley, green, herbaceous, animalic, dill, caraway, citrusy, sweet citrus, straw-like and bergamot undertones to soaps, cosmetics, detergents (including anionic, cationic, nonionic or zwitterionic solid or liquid detergents) or other products. The amount employed can range up to 70% of the fragrance components and will depend upon considerations of cost, nature of the end product, the effect desired on the finished product and the particular fragrance sought.
The 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention are useful (taken alone or together with other ingredients in perfume compositions) in detergents and soaps, space odorants, perfumes, colognes, toilet water, bath preparations such as lacquers, brilliantines, pomades and shampoos; cosmetic preparations, such as creams, deodorants, hand lotions and sun screens; powders such as talcs, dusting powders, face powders and the like. As little as 0.25% of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention will suffice to impart an intense and long-lasting green, herbaceous, basil, parsley, rose, fruity, mandarin orange peel, spicy, earthy, root, sauge sclaree, minty, woody, celery-like, citrusy, seashore, fresh, clean, ozoney, tangerine-like, grapefruit-like, Nootkatone-like, jasmine, dill, caraway, nutty, coconut, floral, peach-like, apricot-like, caramel-like, maple syrup and new moun hay aromas with galbanum, jasmine, celery-like, green, cinnamon, pineapple, oak moss, almond oil, animalic, herbaceous, camphoraceous and eucalyptus-like topnotes and with fruity, floral, jasmine, lily of the valley, green, herbaceous, animalic, dill, caraway, citrusy, sweet citrus, straw-like and bergamot undertones to citrusy, woody, floral, herbaceous and earthy perfume formulations. Generally, no more than 5% of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention based on the ultimate end product is required to be used as is or in perfume compositions.
Furthermore, as little as 0.25% of the 2,4-disubstituted and 2,2,4-trisubstitued tetrahydropyranyl-4-ethers of our invention will suffice to impart such aroma to perfumed articles per se, whether in the presence of other perfume materials or whether used by themselves. Thus, the range of use of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention in perfumed articles may vary from about 0.25% up to about 5% by weight based on the total weight of the perfumed article.
In addition, the perfume composition or fragrance composition of our invention can contain a vehicle or carrier for the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention. The vehicle can be a liquid such as a non-toxic alcohol, e.g., ethanol, a non-toxic glycol, e.g., propylene glycol or the like. The carrier can also be an absorbent solid, such as a gum (e.g., gum arabic), or components for encapsulating the composition by means of coacervation (such as gelatin).
It will thus be apparent that the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention can be utilized to alter, modify or enhance the aroma of perfume compositions, colognes or perfumed articles.
Furthermore, several processes may be used in order to produce a thickened, highly viscous hypochlorite bleaching or sterilizing solution whereby the desired aroma profiles are imparted to the articles treated with said hypochlorite solutions.
Thus, for example, the 2,4-disubstituted and 2,2,4-trisubstitued tetrahydropyranyl-4-ethers of our invention may be premixed with the diphenyl oxide derivative or diphenyl oxide derivative-amine oxide solubilizer-stabilizer (having the structures, respectively: ##STR168## and the resulting 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers/diphenyl oxide derivative or 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers-diphenyl oxide derivative-amine oxide premix is then mixed with the hypochlorite bleaching or sterilzing solution with stirring. Immediately after such addition, an aqueous alkali metal hydroxide solution is added to the mixture to bring the pH to the range of 11-14.0. A pH of less than 11 is not desired since it is difficult to achieve a single phase stable system at low pH's. A pH higher than 14.0 will also create a system which (1) is unnecessarily corrosive; (2) will narrow the range of perfume oils useable (in conjunction wit the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers) of the system and (3) will limit the particular ingredients useable in such perfume oils in conjunction with the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers. On the other hand, if for example, the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers is used alone or further in combination with (i) diisoamylene epoxides; (ii) diisoamylenes as described in application for U.S. Letters Patent, Ser. No. 188,576 filed on Oct. 9, 1980; or (iii) acyl diisoamylene derivatives described in application for U.S. Letters Patent, Ser. No. 184,132 filed on Sept. 4, 1980 and/or (iv) ketal derivatives of acyl diisoamylene derivatives described in application for U.S. Letters Patent, Ser. No. 212,993 filed on Dec. 4, 1980, a pH of about 14.0 and even slightly higher (e.g., 14.1) is acceptable.
The aqueous alkali metal hydroxide can be added to the aqueous alkali metal hypochlorite solution before adding the diphenyl oxide derivatives (taken alone or in conjunction with the amine oxide) or the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers or mixtures of 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers with other materials such as diisoamylene epoxides. Indeed, the ingredients: the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers; the alkali metal hydroxide and the diphenyl oxide derivative or diphenyl oxide derivative-amine oxide composition (having the structures, respectively: ##STR169## may be added or admixed in any order which is convenient to the formulator. One desirable process involves first forming the diphenyl oxide derivative or diphenyl oxide derivative-amine oxide composition-2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers "premix", mixing the premix with the alkali metal hypochlorite solution and finally adjusting the pH of the solution with alkali metal hydroxide to bring the pH to within the range of 11-14.0. A second, more preferable process, involves first adjusting the pH of the aqueous alkali metal hypochlorite solution to 11-14.0 and then admixing the solution with the aforedescribed "premix".
The alkali metal hypochlorites preferred in the practice of our invention are: sodium hypochlorite, potassium hypochlorite and lithium hypochlorite or mixtures of same. The alkali metal hypochlorites preferred in the practice of this invention are: lithium hydroxide, potassium hydroxide and sodium hydroxide, or, if desired, mixtures of such hydroxides.
The temperature at which the composition of our invention remains both substantially stable and commercially useful for the purposes set forth herein (that is, remains as a clear single aqueous or gel phase) and retains (1) the desired properties inherent in the known bleaching and sterilizing uses of aqueous alkali metal hypochlorite liquid or gel solutions, and (2) the properties imparted thereto as a result of the use of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers which impart to articles previously subjected to the aqueous alkali metal hypochlorite gel or liquid solutions a desired aroma profile, varies from approximately 20.degree. F. up to approximately 120.degree. F. At temperatures below 20.degree. F. a two-phase system usually occurs and at temperatures higher than 120.degree. F. the bleaching or sterilizing efficiency of the compositions of our invention is diminished at an excessive rate.
When it is desired to (1) initially from the C.sub.10 -C.sub.12 straight chain or branched chain diphenyl oxide alkali metal sulfonate or diphenyl oxide derivative-amine oxide-2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ether premix; (2) then combine the resulting premix with an alkali metal hypochlorite solution; (3) then add the thickening agent and then (4) adjust the pH of the resulting solution to the range of 11-14.0, then the temperature of mixing ranges are considered to be within the scope of this invention as follows:
______________________________________(a) Formation of the diphenyl oxide 20.degree. F.-150.degree. F. derivative or diphenyl oxide-amine oxide-2,4-disubstituted and 2,2,4-trisubstituted tetra- hydropyranyl-4-ethers premix(b) Mixing the premix with aqueous 20.degree. F.-120.degree. F. metal alkali hypochlorite solution followed by thickening agent(c) Adjustment of pH of the solution 20.degree. F.-120.degree. F. to the range of 11-14.0 using aqueous alkali metal hydroxide solution.______________________________________
In any event, wherever a mixing unit operation involves the aqueous alkali metal hypochlorite solution, the temperature of mixing is limited to the range of 20.degree. F.-120.degree. F. Where the mixing unit operation involves the mixing of 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers, the upper bound of the temperature range is limited by the stability of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers or other perfume ingredient mixed with the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers useable in the practice of our invention; and the lower bound of said temperature range is limited by the least temperature where a single liquid phase or gel phase including the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers or other ingredient admixed therewith will exist. Where a unit mixing operation of the process of our invention involves the mixing of one or more diphenyl derivatives having the generic structure: ##STR170## taken alone or taken together with one or more amine oxides having the generic structure: ##STR171## with other materials, the upper bound of the temperature range is the decomposition point of any one of the diphenyl oxide derivatives or amine oxide components and the lower bound is the least temperature where a single liquid phase or gel phase, including the diphenyl oxide derivatives or diphenyl oxide-amine mixture will exist.
Preferred diphenyl oxide derivative compositions from a practical standpont useful in the practice of our invention are compounds having the structure: ##STR172## where the C.sub.12 H.sub.25 moiety represents one or a series of different branched chains; compounds defined according to the structure: ##STR173## where the C.sub.12 H.sub.25 moiety represents one or a series of different branched chains; compounds defined according to the structure: ##STR174## and compounds defined according to the structure: ##STR175## otherwise known as DOWFAX.RTM.2A1 in the case where one or R.sub.1 or R.sub.2 represents branched C.sub.12 H.sub.25 alkyl chains and the other of R.sub.1 or R.sub.2 represents hydrogen, or DOWFAX.RTM.3B2 in the case where one of R.sub.1 or R.sub.2 represents straight C.sub.10 alkyl chain and the other of R.sub.1 or R.sub.2 represents hydrogen (DOWFAX.RTM. being a registered trademark of the Dow Chemical Company of Midland, Mich.).
When used in conjunction with the diphenyl oxide derivatives preferred amine oxide compositions, from a practical standpoint, useful in the practice of our invention are the commercially available (1) dimethyl "cocoamine" oxide (a mixture which is dominated by dimethyl-C.sub.12 -C.sub.16 straight chain alkyl amine oxides: more particularly a mixture containing approximately 70% C.sub.12 straight chain alkyl amines oxides, approximately 25% of straight chain C.sub.14 alkyl amine oxides and approximately 4% straight chain C.sub.16 alkyl amine oxides) and (2) N-cocomorpholine oxide, a mixture dominated by straight chain C.sub.12 -C.sub.16 alkyl morpholine oxides (specifically containing approximately 70% straight chain C.sub.12 alkyl morpholine oxide, approximately 25% straight chain C.sub.14 alkyl morpholine oxide, and approximately 4% straight chain C.sub.16 alkyl morpholine oxide). Commercial examples of such amine oxide compositions are: AROMOX.RTM. DMC-W and AROMOX.RTM. DMMC-W which are 30% aqueous dimethyl cocoamine oxide solutions and AROMOX.RTM. NCMDW which is a 40% aqueous N-cocomorpholine oxide solution each of which is produced by the Armac Division of AKZO of Chicago, Ill. These materials are described in Brochure 68011, published by Armous Industrial Chemicals, P.O. Box 1805, Chicago, Ill. 60690. Other preferred amine oxides are n-undecyl dimethyl amine oxide and n-tridecyl dimethyl amine oxide.
The percentage of hypochlorite ion in the compositions of our invention may vary from about 1% up to about 20% for the desired effects to be produced using the diphenyl oxide derivative or diphenyl oxide derivative-amine-oxide 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers compositions covered by our invention. The usual percent of alkali metal hypochlorite in solution is about 5%, the percentage of sodium hypochlorite in such mixtures as CLOROX.RTM. the registered trademark of the Clorox Corporation.
The perfume oil used in conjunction with the 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention which, in turn, is used in conjunction with the aqueous alkali metal hypochlorite solution must have such properties as to be able (1) to be compatible with the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention; (2) to impart to the resulting or "aqueous alkali metal hypochlorite" liquid or gel solution a pleasing aroma which harmonizes with the aroma of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers; (3) to effect a substantial diminution or elimination of the disagreeable "hypochlorite" aroma which is imparted to surfaces (e.g., bleached laundry or the hands of the user which are in direct contact with the hypochlorite solution) on which known aqueous alkali metal hypochlorite solutions have been used; and (4) to impart to the surfaces with which such aqueous alkali metal hypochlorite solutions are in contact, a pleasant long lasting stable aroma. Examples of ingredients compatible with 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers and suitable for the aforementioned purposes, that is, useable in conjunction with the hypochlorites, amine oxide derivatives and diphenyl oxide derivatives of our invention are as follows:
1. Cedryl alkyl ethers covered by U.S. Pat. No. 3,373,208 such as cedryl methyl ether;
2. Isochroman musks covered by U.S. Pat. Nos. 3,360,530 and 3,591,528 such as 6-oxa-1,1,3,3,8-pentamethyl-2,3,5,6,7,8-hexahydro-1H-benz(1)indene;
3. Polycyclic ethers covered by U.S. Pat. No. 3,281,432, such as octahydro-1,3a-6-trimethyl-1H-1,6a,ethanopentaleno-(1,2-C)furan;
4. Polycyclic ketones such as hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalen-8-(5H)one;
5. Diisoamylenes described according to application for U.S. Letters Pateent, Ser. No. 188,576 filed on Sept. 18, 1980;
6. Acyldiisoamylene derivatives described according to application for U.S. Letters Patent, Ser. No. 184,132 filed on Sept. 4, 1980 and ketal derivatives thereof described according to application for U.S. Letters Patent, Ser. No. 212,993 filed on Dec. 4, 1980; and
7. Diisoamylene epoxide derivatives according to application for U.S. Letters Patent, Ser. No. 231,773 filed on Feb. 27, 1981.
It will be understood that a number of materials which impart to the citrusy or floral aromas of certain of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention additional eucalyptol-like, or minty or woody nuances will not be useful for the practice of that aspect of our invention concerning perfumed hypochlorite bleaches because they are, interalia, easily oxidized by the alkali metal hypochlorite in the system. Examples are 1,5,9-trimethyl-12-acetyl-cyclododecatriene-1,5,8 and 1,5,9-trimethyl-12-cyclodeadiene-1,8 covered by British Patent No. 1,204,409.
A basic feature of our invention concerns the fact that the only detergent group needed or desirable in the composition of our invention is the class of diphenyl oxide derivatives defined according to the structure: ##STR176## wherein R.sub.1, R.sub.2, M and N are defined, supra, taken alone or in conjunction with the class of morpholino and/or dimethyl C.sub.11 -C.sub.13 straight chain alkyl amine oxides defined according to the structure: ##STR177## More specifically, such detergents as sodium decyl ether sulfate, sodium myristyl ether sulfate, sodium lauryl ether sulfate and lithium lauryl ether sulfate are neither desire nor are they required. Furthermore, the well known hydrotropes employed in prior art compositions such as the well known families of clarifying agents comprising the alkali metal or alkai earth metal salts of mono- and polyalkylated benzene or naphthalene sulfonates such as sodium xylene or magnesium toluene sulfonate are again neither desired nor are they required in the composition intended to be encompassed by the instant invention.
Another basic feature of our invention concerns the fact that when it is desired to have a gel phase composition, thickener agents may be employed in conjunction with the system; hypochlorite bleach-2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers-diphenyl oxide derivative or plain oxide derivative-amine oxide derivative (having the general structure) ##STR178## and having the structure: ##STR179## of our invention.
Still another basic feature of our invention concerns the fact that the gel phase compositions including thickener agents are employed with the "premix" system; 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers-diphenyl oxide derivative or diphenyl oxide derivative-amine oxide of our invention.
Thus, sodium palmitate, sodium stearate, sodium laurate, potassium palmitate, potassium stearate, potassium laurate, lithium palmitate, lithium stearate and/or lithium laurate or combinations of the foregoing may be added to the compositions of matter of our invention to provide a thickened gel-type hypochlorite bleach which is, in addition to being a semi-solid state, is unobviously, advantageously and unexpectedly stable over long periods of time. Percentages of thickening agents such as sodium palmitate, sodium stearate, sodium laurate, potassium palmitate, potassium stearate, potassium laurate, lithium palmitate, lithium stearate or lithium laurate or combinations of these which may be used in the thickened compositions of our invention are from 1% by weight up to 12% by weight of the thickener based on the overall weight of hypochlorite bleach-diphenyl oxide-derivative (or diphenyl oxide derivative-amine oxide)2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers composition of our invention. When it is merely desired to have a thickened "premix" the percentage of thickening agent may very from about 5% up to about 40% by weight of thickener based on overall weight of "premix".
The following Examples I-XX serve to illustrate processes for producing the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention. Examples following Example XX, e.g., Examples XXI, et seq. illustrate the organoleptic uses of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention.
It will be understood that these examples are illustrative and that the invention is to be considered restricted thereto only as indicated in the appended claims. All parts and percentages given herewith are by weight unless otherwise specified.
The following table illustrates organoleptic properties of certain precursor alcohols of the prior art compounds which may be used in producing certain of the 2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers of our invention:
TABLE II______________________________________Prior Art Compound Structure Organoleptic Utilities______________________________________ ##STR180## A nasturtium aroma profile.produced accordingto U.S.S.R. PatentNo. 620,847 of July 17,1987 the specification forwich is incorported byreference herein (abstractedat Chem. Abstracts, Volume 89,No. 185929p). ##STR181## A nerol, caramel, methacry- late, chamomile aroma with a non descript undertone.produced accordingto Example I of appli-cation for U.S. LettersPat. Ser. No. 308,182filed on February 9, 1989,the specification of which isincorporated by referenceherein. ##STR182## A floral (muguet), spicy (nutmeg) aroma profile with a weak muguet topnote.produced accordingto Example VII of appli-cation for U.S. LettersPat. Ser. No. 308,182filed on Feb. 9, 1989,the specification of whichis incorporated byreference herein. ##STR183## A terpenic, flat floral (muguet) aroma profile with floral (muguet/freesia) undertones. ##STR184## A sweet, muguet, green aroma with floral (muguet) topnotes.purchased under thename "FLORAL.RTM. " fromthe Firmenich, et Cie S.A.of Geneva, Switzerland.______________________________________
EXAMPLE I
Preparation of Tetrahydro-4-Methoxy-4-Methyl-2-n-Propyl-2H-Pyran
Reactions: ##STR185##
A solution of 7 grams of sulfuric acid is intimately admixed with 344 grams of isoprenol.
Into a 2 liter reaction vessel equipped with stirrer, thermometer and reflux condenser and cooling bath are placed 288 grams of butyraldehyde, 530 grams of trimethylorthoformate and 100 grams of methanol. The resulting mixture is cooled to -5.degree. C. and then allowed to reach +10.degree. C. While maintaining the reaction mass at 10.degree. C., dropwise over a period of 0.5 hours, 8 grams of concentrated hydro-chloric acid is added thereto. The temperature of the reaction mass is then permitted to rise to room temperature.
The reaction mass is quenched by adding thereto 8 grams of sodium acetate followed by 600 ml water and stirring for ten minutes.
The resulting organic phase is separated from the aqueous phase.
The previously-prepared mixture containing 344 grams of isoprenol is then admixed with the reaction mass slowly over a two hour period.
The resulting reaction product is quenched with 60 grams of 50% aqueous sodium hydroxide followed by 300 grams of water. The organic phase is separated from the aqueous phase and the organic phase is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 45/ 74/ 3/302 48 74 103 48 74 104 48 77 105 48 80 106 55 83 107 70 85 108 74 86 109 75 93 1010 75 92 1011 75 103 1012 77 106 1013 90 130 10.______________________________________
FIG. 1 is the GLC profile for the reaction product prior to distillation.
The peaks indicated by reference numerals 10 and 11 are for the compound having the structure: ##STR186## The peaks indicated by reference numerals 12 and 13 are for the mixture of compounds defined according to the structure: ##STR187## wherein in the mixture in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Fractions 8-13 when bulked contain solely the compound having the structure: ##STR188##
The compound having the structure: ##STR189## has a green, herbaceous, parsley, rose, fruity, spicy and earthy and rooty aroma profile,
FIG. 2 is the NMR spectrum for distillation Fraction 11 which is for the compound having the structure: ##STR190##
EXAMPLE II
Preparation of Tetrahydro-2-isopropyl-4-methoxy-4-methyl-2H-pyran
Reactions: ##STR191##
The procedure of Example I is carried out with the exception that the following ingredients (with their weights) are used in place of the reagents in Example I:
______________________________________Reagent Weight______________________________________Isobutyraldehyde 288 grams (4 moles)Trimethylorthoformate 530 grams (5 moles)Concentrated hydro- 4 mlchloric acidSodium acetate 8 gramsIsoprenol 344 gramsSulfuric acid 6 gramsconcentractedSodium hydroxide 60 grams(50% aqueous sodiumsolution)______________________________________
After the reaction mass is quenched, the organic phase is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 16/ 18/ 2.42 35 69 2.23 30 70 2.54 40 74 2.45 51 80 2.86 55 80 3.27 56 90 3.28 54 86 3.09 56 94 3.210 61 98 3.611 66 108 3.712 74 118 3.4.______________________________________
Fractions 7-12 contain solely the compound having the structure: ##STR192##
Fractions 2-5 contain solely the mixture of compounds having the structure: ##STR193##
The compound having the structure: ##STR194## has a sauge sclaree, minty and woody aroma profile. The mixture of compounds having the structure: ##STR195## has a floral, green and minty aroma profile.
EXAMPLE III
Preparation of 2-Butyltetrahydro-4-methoxy-4-methyl-2H-pyran
Reactions: ##STR196##
A procedure is carried out similar to the procedure of Example I with the exception that the following reagents are used:
______________________________________Reagent Quantity______________________________________N-Pentanal 344 gramsTrimethylorthoformate 530 gramsConcentrated Hydro- 4 mlchloric acidMethyl alcohol 100 mlSodium Acetate 8 gramsIsoprenol 344 gramsSulfuric acid 8 grams(concentrated)50% Aqueous Sodium 60 gramsHydroxide______________________________________
Subsequent to the workup, the organic phase is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 42/ 78/ 2.02 53 86 5.03 59 91 6.54 62 91 6.55 68 95 7.06 79 96 6.57 83 96 6.08 85 97 6.09 85 97 6.010 86 98 6.011 86 100 6.012 87 103 6.013 84 118 6.014 79 147 6.015 79 180 6.0.______________________________________
Fractions 12, 13 and 14 consist of the compound having the structure: ##STR197##
The compound having the structure: ##STR198## has a fruity, herbaceous, celery-like, citrusy aroma with fruity, floral, jasmine, lily of the valley, green and herbaceous undertones.
Fractions 2-10 consist of the mixture of compounds defined according to the generic structure: ##STR199## wherein in each of the compounds, one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
EXAMPLE IV
Preparation of Tetrahydro-4-methoxy-4-methyl-2-N-pentyl-2H-pyran
Reactions: ##STR200##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used in the reactions:
______________________________________Reagent Weight______________________________________n-Hexanal 400 gramsTrimethylorthoformate 530 gramsMethyl Alcohol 100 gramsSodium Acetate 8 gramsIsoprenol 344 gramsSulfuric Acid 8 grams(concentrated)50% Aqueous Sodium 60 gramsHydroxide______________________________________
After the workup the organic phase is distilled on a micro vigreux column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________ 1 32/ 88/ 2.4 2 48 92 2.4 3 55 94 2.4 4 56 94 2.4 5 56 97 2.4 6 57 97 2.4 7 58 100 2.4 8 60 103 2.4 9 67 105 2.410 71 105 2.411 75 107 2.412 77 107 2.413 77 107 2.414 78 107 2.415 78 107 2.416 82 108 2.417 82 108 2.418 58 180 2.6.______________________________________
Fractions 10-18 consist of the compound having the structure: ##STR201##
The compound having the structure: ##STR202## has a fresh, clean, tangerine-like, fruity, jasmine aroma with galbanum, jasmine, celery-like, green and pineapple topnotes.
EXAMPLE V
Preparation of Morflorate Methyl Ether
Reactions: ##STR203##
A procedure is carried out similar to the procedure of Example I with the exception that the following reagents are used in the reaction:
______________________________________Reagent Weight______________________________________Isovaleraldehyde 516 gramsTrimethylorthoformate 756 gramsConcentrated Hydrochloric 12 mlAcidSodium Acetate 20 gramsIsoprenol 602 gramsSulfuric Acid 5 grams(concentrated)______________________________________
After the reaction mass is quenched the organic phase is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 23/78 23/100 1.52 76 90 6.03 76 90 6.04 78 96 6.05 80 96 4.06 80 96 4.07 80 96 3.08 80 96 3.09 80 96 3.010 82 100 3.011 85 110 3.012 70 150 2.013 70 180 2.0.______________________________________
Fractions 2-5 consist of the mixture of compounds defined according to the structure: ##STR204## wherein in the mixture, one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represnt carbon-carbon single bonds.
Fractions 7-13 consist of the compound having the structure: ##STR205##
The compound having the structure: ##STR206## has a green, herbaceous and woody aroma profile with floral undertones.
EXAMPLE VI
Preparation of Tetrahydro-4-methoxy-4-methyl-2(1-methylbutyl)-2H pyran
Reactions: ##STR207##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________2-Methylpentanal 400 gramsTrimethylorthoformate 530 gramsMethyl Alcohol 100 gramsConcentrated Hydrochloric 4 mlAcidSodium Acetate 8 gramsIsoprenol 344 gramsSulfuric Acid 7 grams(concentrated)Sodium Hydroxide 60 grams(50% Aqueous)______________________________________
After quenching the organic phase is distilled on a 11/2".times.15" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 56/ 98/ 6.02 72 100 6.03 74 103 5.54 75 103 6.05 77 105 6.06 78 106 6.07 80 108 6.08 85 108 6.09 94 110 6.010 100 110 6.011 101 112 6.012 102 112 6.013 102 112 6.014 103 115 6.015 104 120 6.016 64 164 6.517 140 180 6.5.______________________________________
Fractions 9-16 consist of the compound having the structure: ##STR208##
The compound having the structure: ##STR209## has a spicy, dill, caraway, herbaceous aroma with animalic, dill and caraway undertones.
Fractions 2-21 consist of the mixture of compounds defined according to the structure: ##STR210## wherein in the mixture in each of the compounds one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines are carbon-carbon single bonds. The mixture of compounds having the structure: ##STR211## has a floral, green, minty, pepper and rose aroma profile.
EXAMPLE VII
Preparation of Tetrahydro-4-Methoxy-4-Methyl-2(1-Methyl-1-Butenyl)-2H-Pyran
Reactions: ##STR212##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________2-Methyl-2-Pentenal 392 gramsTrimethylorthoformate 530 gramsMethyl Alcohol 100 gramsConcentrated Hydrochloric 4 mlAcidSodium Acetate 8 gramsIsoprenol 344 gramsSulfuric Acid 7 grams(concentrated)50% Aqueous Sodium 60 gramsHydroxide______________________________________
After quenching the organic phase is distilled on a 1".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 22/ 115/2 20 110 4.03 50 112 5.54 73 117 5.05 83 122 5.06 96 127 5.07 97 125 5.08 106 127 5.09 104 152 5.010 110 168 6.011 114 182 6.012 116 185 6.0.______________________________________
Fractions 7-11 (bulked) consist of the compound having the structure: ##STR213##
The compound having the structure: ##STR214## has a nutty and coconut aroma profile with cinnamon and pineapple topnotes and floral and herbaceous undertones.
EXAMPLE VIII
Preparation of Tetrahydro-4-Methoxy-4-Methyl-2-Phenyl-2H-Pyran
Reactions: ##STR215##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________Benzaldehyde 424 gramsTrimethylorthoformate 530 gramsMethyl Alcohol 110 gramsSodium Acetate 8 gramsIsoprenol 344 gramsSulfuric Acid 8 gramsIsoprenol 344 gramsSulfuric Acid 8 grams(concentrated)Sodium Hydroxide 60 grams(50% solution)Concentrated 4 mlHydrochloric Acid______________________________________
After quenching the reaction mass is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________ 1 70/ 123/ 4.0 2 96 124 4.0 3 96 124 4.0 4 96 126 4.0 5 96 128 4.0 6 96 128 4.0 7 96 128 4.0 8 98 132 4.0 9 98 132 4.010 103 133 3.811 111 134 3.812 115 134 3.813 115 134 3.814 115 134 3.815 116 134 3.816 120 150 3.817 120 150 3.818 115 193 3.819 90 210 1.6.______________________________________
Fractions 12-18 consist of the compound having the structure: ##STR216##
Fractions 3-8 consist of the mixture of compounds defined according to the structure: ##STR217##
The compound having the structure: ##STR218## has a spicy aroma with oak moss topnotes.
The mixture of compounds having the structure: ##STR219## has a floral, sweet, rose aroma.
EXAMPLE IX
Preparation of 2-Hexyltetrahydro-4-Methoxy-4-Methyl-2H-Pyran
Reactions: ##STR220##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________n-Heptaldehyde 456 grams (4 moles)Trimethylorthoformate 530 grams (5 moles)Concentrated Hydrochloric 4 mlAcidSodium Acetate 8 gramsIsoprenol 344 grams (4 moles)Sulfuric Acid 8 grams(concentrated)Sodium Hydroxide 70 grams(50% Aqueous)______________________________________
After quenching the organic phase is distilled on a 11/2".times.12" Goodlow column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________ 1 48/ 92/ 4.0 2 45 93 3.0 3 45 93 3.0 4 49 93 6.0 5 47 94 6.0 6 56 104 6.0 7 50 104 6.0 8 78 108 6.0 9 83 108 6.010 85 112 6.011 85 114 6.012 85 114 6.013 86 115 6.014 91 128 6.015 93 119 6.016 100 121 6.017 105 122 6.018 108 125 6.019 109 128 6.020 108 127 6.021 108 130 6.022 108 139 6.023 108 160 6.024 112 170 6.025 132 180 6.026 138 200 6.027 130 200 1.8.______________________________________
Fractions 10-15 consist of the mixture of compounds having the structure: ##STR221## wherein in the mixture in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Fractions 17-23 consist of the compound having the structure: ##STR222##
The compound having the structure: ##STR223## has a fruity, herbaceous, floral aroma with citrusy, herbaceous and floral undertones.
The mixture of compounds having the structure: ##STR224## has a floral, green and galbanum aroma.
EXAMPLE X
Preparation of 2-n-Heptyltetrahydro-4-Methoxy-4-Methyl-2H-Pyran
Reactions: ##STR225##
A procedure similar to that of Example I is carried out with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________n-Octyl Aldehyde 513 grams (4 moles)Trimethylorthoformate 530 grams (5 moles)Methyl Alcohol 100 gramsConcentrated Hydrochloric 5 mlAcidSodium Acetate 8 gramsSulfuric Acid 8 grams(concentrated)Isoprenol 344 grams (4 moles)50% Sodium Hydroxide 60 grams______________________________________
After quenching the organic phase is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 65/ 112/ 5.02 91 115 5.03 92 118 5.04 93 118 5.05 94 118 5.06 94 121 5.07 96 124 5.08 97 128 5.09 98 130 5.010 116 134 5.011 122 138 5.512 120 138 5.313 115 136 4.614 117 142 4.615 118 162 4.616 114 182 4.617 128 200 4.6.______________________________________
Fractions 2-9 consist of the mixture of compounds having the structure: ##STR226## wherein in the mixture in each of the compounds one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Fractions 11-15 consist of the compound having the structure: ##STR227##
The compound having the structure: ##STR228## has a fruity, peach and coconut-like aroma profile with almond oil topnotes.
The mixture of compounds having the structure: ##STR229## has a green, Rue oil-like aroma profile.
EXAMPLE XI
Preparation of Tetrahydro-4-Methoxy-4-Methyl-2-n-Octyl-2H-Pyran
Reactions: ##STR230##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________n-Nonyl Aldehyde (95%) 250 grams (1.67 moles)Trimethylorthoformate 221 grams (2.09 moles)Methyl Alcohol 50 gramsConcentrated Hydrochloric 2 mlAcidSodium Acetate 4 gramsIsoprenol 143 grams (1.67 moles)Sulfuric Acid 3.5 grams(concentrated)Sodium Hydroxide 30 grams(50% Aqueous)______________________________________
After quenching, the organic phase is distilled on a 11/2".times.15" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 80/ 130/ 4.02 101 126 3.53 105 130 3.54 105 131 3.55 105 133 3.56 105 133 3.57 107 142 3.58 102 144 3.59 125 155 3.210 125 170 3.211 125 185 3.212 125 200 3.213 124 215 1.9.______________________________________
The compound having the structure: ##STR231## has a fresh, ozoney, seashore aroma with animalic topnotes.
The mixture of compounds defined according to the structure: ##STR232## (wherein in the mixture in each of the compounds, one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds) has a citrusy, "air-dried clothing" aroma profile.
EXAMPLE XII
Preparation of 4-Ethoxy-2-Ethyltetrahydro-4-Methyl-2H-Pyran
Reaction: ##STR233##
Into a 2 liter reaction vessel equipped with stirrer, thermometer and reflux condenser is added 508 grams of propionaldehyde diethyl acetal. The propionaldehyde diethyl acetal is heated to 80.degree. C. with stirring.
Separately, a solution containing 8.6 grams of sulfuric acid and 330 grams of isoprenol is pre-prepared.
The pre-prepared sulfuric acid-isoprenol solution is added dropwise over a period of 1.5 hours to the propionaldehyde diethyl acetal.
After the addition of the isoprenol-sulfuric acid solution the reaction mass is stirred at a temperature of 80.degree. C.
The reaction mass is then quenched with 58 grams of a 50% aqueous solution of sodium hydroxide followed by 500 ml water.
The crude reaction product is then distilled on a 1.5.times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 34/ 63/ 6.02 34 67 6.03 49 71 6.04 55 73 6.05 57 74 6.06 60 76 6.07 60 78 6.08 63 85 6.09 63 101 6.0.______________________________________
The compound having the structure: ##STR234## has a caramel, maple syrup aroma with green, herbaceous topnotes.
EXAMPLE XIII
Preparation of Tetrahydro-2-Isopropyl-4-Methoxy-2,4-Dimethyl-2H-Pyran
Reactions: ##STR235##
A procedure similar to that of Example I is carried out with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________3-Methylbutanone-2 344 gramsTrimethylorthoformate 530 gramsMethyl Alcohol 100 gramsConcentrated Hydrochloric 4 mlAcidSodium Acetate 8 gramsConcentrated 8 gramsSulfuric AcidIsoprenol 344 grams50% Aqueous 60 gramsSodium Hydroxide______________________________________
After quenching, the organic phase is distilled on a 1.5.times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________ 1 42/ 72/ 4.0 2 42 72 4.0 3 42 72 5.0 4 42 72 6.0 5 44 72 6.0 6 48 74 6.0 7 50 76 8 52 82 6.0 9 55 84 8.010 57 85 8.011 65 87 8.012 72 87 7.513 75 87 7.514 76 92 7.515 81 94 7.516 81 94 7.517 80 102 8.018 78 134 8.019 60 177 8.520 30 200 8.0.______________________________________
Fractions 11-20 consist of the compound having the structure: ##STR236##
The compound having the structure: ##STR237## has a minty, woody, green, herbaceous aroma with camphoraceous and eucalyptus-like topnotes.
EXAMPLE XIV
Preparation of Tetrahydro-2-Isobutyl-4-Methoxy-2,4-Dimethyl 2H-Pyran
Reactions: ##STR238##
A procedure is carried out similar to that of Example XII except that the following reagents are used:
______________________________________Reagent Weight______________________________________Methylpentanone Dimethyl 600 gramsKetalIsoprenol 600 gramsConcentrated 6 gramsSulfuric Acid10% Aqueous 1 literSodium CarbonateQuench Solution______________________________________
After quenching the organic phase is distilled on a 1.5.times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg.No. (.degree.C.) (.degree.C.) Pressure______________________________________1 23/65 23/90 25/102 65 90 10.03 68 93 8.04 70 72 8.05 70 96 3.06 70 96 2.07 78 98 2.08 78 96 2.09 78 96 2.010 78 95 2.011 78 98 2.012 70 116 1.013 65 122 1.014 65 165 2.0.______________________________________
The resulting compound having the structure: ##STR239## has a citrusy, grapefruit and nootkatone-like aroma profile.
EXAMPLE XV
Preparation of 2-n-Hexyltetrahydro-4-Methoxy-2,4-Dimethyl-2H-Pyran
Reactions: ##STR240##
The procedure of Example I is utilized with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________2-Octanone 512 gramsTrimethylorthoformate 530 gramsMethyl Alcohol 100 gramsConcentrated 5 ml.Hydrochloric AcidSodium Acetate 10 gramsIsoprenol 344 grams (4 moles)Concentrated 9 gramsSulfuric Acid50% Aqueous 60 gramsSodium Hydroxide______________________________________
After quenching the organic phase is distilled on a B 1".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________ 1 58/ 5.0 3:1 2 83 123 5.0 3:3 3 85 127 5.0 3:1 4 94 117 10.0 3:1 5 95 124 10.0 3:1 6 96 125 10.0 3:1 7 97 129 10.0 3:1 8 97 129 10.0 3:1 9 98 134 10.0 3:110 100 135 10.0 3:111 107 137 10.0 3:112 112 135 11.0 3:113 112 136 10.0 3:114 112 137 10.0 3:116 112 138 10.0 3:117 118 140 10.0 3:118 112 141 10.0 3:119 112 137 9.0 3:120 112 145 9.0 3:1.______________________________________
Fractions 4-9 bulked consist of the mixture of compounds defined according to the structure: ##STR241## wherein in the mixture in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Fractions 12-19 consist of the compound having the structure: ##STR242##
The compound having the structure: ##STR243## has a green, herbaceous aroma with animalic undertones.
The mixture of compounds having the structure: ##STR244## has a fruity, peach, coconut aroma profile with green and fruity topnotes.
EXAMPLE XVI
Preparation of Tetrahydro-4-Methoxy-2,4-Dimethyl-2-Phenyl-2H-Pyran
Reactions: ##STR245##
The procedure of Example I is carried with the exception that the following reagents are utilized:
______________________________________Reagent Weight______________________________________Acetophenone 464 grams (4 moles)Trimethylorthoformate 530 grams (5 moles)Methyl Alcohol 100 gramsSodium Acetate 8 gramsConcentrated 5 mlHydrochloric AcidIsoprenol 344 gramsConcentrated 9 gramsSulfuric Acid50% Aqueous 60Sodium Hydroxide______________________________________
After quenching the organic phase is distilled on a 11/2".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 74/ 116/ 5 0 3:12 93 116 5.0 3:13 93 117 5.0 3:14 94 118 5.0 3:15 95 123 5.0 3:16 97 130 4.6 3:17 98 135 4.6 3:18 107 145 4.6 3:19 108 153 4.6 3:110 110 170 4.8 3:111 100 195 4.8 100%12 100 210 4.8 100%.______________________________________
Fractions 8-11, bulked consist of the compound having the structure: ##STR246##
Fractions 2-5 (bulked) consist of the mixture of compounds having the structure: ##STR247## (wherein in the mixture, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds).
The mixture of compounds having the structure: ##STR248## has a herbaceous, green, petitgrain, citrusy aroma profile.
The compound having the structure: ##STR249## has a new mown hay aroma with green, herbaceous, straw-like undertones.
EXAMPLE XVII
Preparation of 1-Isobutyl-9-Methoxy-9-Methyl-Oxaspiro[4.5]Decane
Reactions: ##STR250##
A procedure is carried out similar to that of Example I with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________2-Isobutylcyclopentanone 236 gramsTrimethylorthoformate 223 gramsMethyl Alcohol 50 gramsConcentrated 2 mlHydrochloric AcidSodium Acetate 4 gramsIsoprenol 144 gramsConcentrated 4 gramsSulfuric Acid50% Aqueous 30 gramsSodium Hydroxide______________________________________
After quenching the organic phase is distilled on a 11/2.times.12" Goodloe column yielding the following fractions.
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 56/ 115 6.0 3:12 64 115 6.0 3:13 79 115 4.0 3:14 84 113 3.5 3:15 87 119 3.5 3:16 88 123 3.5 3:17 93 125 3.5 3:18 102 128 3.5 3:19 107 128 3.5 3:110 108 130 3.5 3:111 108 144 3.5 100%12 108 158 3.5 100%.______________________________________
Fraction 3 consists of the mixture of compounds having the structure: ##STR251## wherein in the mixture, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Fractions 8-12 consist of the compound having the structure: ##STR252##
The compound having the structure: ##STR253## has a jasmine aroma.
The mixture of compounds having the structure: ##STR254## has a green, herbaceous aroma with green, herbaceous undertones.
EXAMPLE XVIII
Preparation of 9-Methoxy-9-Methyl-1-n-Pentyl-Oxaspiro[4.5]Decane
Reactions: ##STR255##
The procedure of Example I is carried out with the exception that the following reagents are utilized:
______________________________________Reagent Weight______________________________________2-Pentyl-Cyclopentanone 238 gramsTrimethylorthoformate 204 gramsMethyl Alcohol 50 gramsConcentrated 2 mlHydrochloric AcidSodium Acetate 4 gramsIsoprenol 132 gramsConcentrated 4 gramsSulfuric Acid50% Aqueous 30 gramsSodium Hydroxide______________________________________
After quenching the organic phase is distilled on a 1".times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 62/ 107/ 3.0 4:12 70 112 4.0 3:13 68 117 2.2 3:14 66 126 1.6 3:15 74 138 3.0 3:16 94 142 2.4 3:17 97 144 2.0 3:18 100 144 2.0 3:19 108 146 2.6 3:110 113 156 3.4 1:111 115 158 3.4 1:112 132 162 3.4 100%13 124 167 2.4 100%14 124 175 2.6 100%.______________________________________
Fractions 5-9 (bulked) consist of the mixture of compounds having the structure: ##STR256## wherein in the mixture in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds.
Fractions 10-14 (bulked) consist of the compound having the structure: ##STR257##
The compound having the structure: ##STR258## has a fruity, peach-like, apricot and jasmine aroma profile.
The mixture of compounds having the structure: ##STR259## has a fruity, peach, jasmine, cocoa aroma profile with costus oil-like and jasmine topnotes.
EXAMPLE XIX
Preparation of 10-Methoxy-10-Methyl-7-Oxaspiro[5.5]Undecane
Reactions: ##STR260##
The procedure of Example I is carried out with the exception that the following reagents are used:
______________________________________Reagent Weight______________________________________Cyclohexanone 392 grams (4 moles)Trimethylorthoformate 530 grams (5 moles)Isoprenol 344 grams (4 moles)Concentrated 4 mlHydrochloric AcidSodium Acetate 8 gramsConcentrated 8 gramsSulfuric Acid50% Aqueous 60 gramsSodium Hydroxide______________________________________
After quenching the organic phase is distilled on a 11/2.times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 43/ 89/ 8.0 3:12 73 93 8.0 3:13 73 95 8.0 3:14 73 97 8.0 3:15 79 103 8.0 3:16 79 105 8.0 3:17 80 105 8.0 3:18 84 108 8.0 3:19 100 109 8.0 3:110 101 112 8.0 3:111 103 117 8.0 3:112 95 116 7.0 3:113 97 126 7.8 3:1.______________________________________
Fractions 9-13 (bulked) consist of the compound having the structure: ##STR261##
The compound having the structure: ##STR262## has a woody, citrusy, mandarine orange peel-like, floral, herbaceous and basil aroma profile with sweet, citrus, bergamot and floral undertones.
EXAMPLE XX
Preparation of 3(or 4)-Methyl-9-Tertiarypental-3-Methoxy-1-Oxaspiro[5.5]Undecan and 3(or 4)-Methyl-9 Tertiarypental-1-Oxaspiro[5.5]-Undec-3-Enes
Reactions: ##STR263##
Into a 2 liter reaction vessel is placed the mixture of 300 grams of 4-tertiarypentyl-1-cyclohexanone; 270 ml toluene; and 9 grams of paratoluene sulfonic acid. The reaction mass is brought to reflux and during refluxing over a period of three hours, dropwise, 159 grams of isoprenol is added.
The reaction mass is then stirred at 80.degree. C. for a period of one hour.
The reaction mass is then quenched with 200 ml water followed by 200 ml 10% aqueous sodium hydroxide.
The organic phase is separated from the aqueous phase and the organic phase is fractionally distilled on a 11/2.times.12" Goodloe column yielding the following fractions:
______________________________________ Vapor Liquid VacuumFraction Temp. Temp. mm/Hg. RefluxNo. (.degree.C.) (.degree.C.) Pressure Ratio______________________________________1 34/ 53/ 2.0 3:22 21 95 2.0 3:23 106 144 3.0 3:24 122 151 3.0 100%5 122 159 3.0 100%6 122 170 3.0 100%7 210 3.0 100%.______________________________________
The compound having the structure: ##STR264## has a herbaceous aroma with fresh, ozoney undertones.
The mixture of compounds having the structure: ##STR265## (wherein in the mixture in each of the compounds, one of the dashed lines represents a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds) has a herbaceous, fruity, plum, prune aroma with ozoney and tea-like undertones.
EXAMPLE XXI
The following Chypre formulations are prepared:
______________________________________ Parts by Weight XXIIngredients (A) XXI(B) XXI(C) XXI(D)______________________________________Musk ambrette 40 40 40 40Musk ketone 60 60 60 60Coumarin 30 30 30 30Oil of bergamot 150 150 150 150Oil of lemon 100 100 100 100Methyl ionone 50 50 50 50Hexyl cinnamic aldehyde 100 100 100 100Hydroxycitronellal 100 100 100 100Oil of Lavender 50 50 50 50Texas cedarwood oil 85 85 85 85Virginia cedarwood oil 30 30 30 30Oil of sandalwood 40 40 40 40(East Indies)Isoeugenol 20 20 20 20Eugenol 10 10 10 10Benzyl acetate 30 30 30 30.alpha.-phenyl ethyl alcohol 40 40 40 40.beta.-phenyl ethyl alcohol 30 30 30 30Oakmoss absolute 30 30 30 30Vetiver oil Venezuela 25 25 25 25 ##STR266## 62 0 0 0prepared to accordingto Example I. ##STR267## 0 62 0 0prepared accordingto Example II. ##STR268## 0 0 62 0prepared accordingto Example III. ##STR269## 0 0 0 62prepared accordingto Example IV.______________________________________
The compound having the structure: ##STR270## prepared according to Example I imparts to this Chypre formulation an intense and long-lasting green, herbaceous, parsley, rose, fruity, spicy, earthy and rooty undertones. Accordingly, the formulation of Example XXI(A) can be described as "Chypre having a green, herbaceous, parsley, rose, fruity, spicy, earthy and rooty" undertones.
The compound having the structure: ##STR271## prepared according to Example II imparts to this Chypre formulation, an intense and long-lasting sauge sclaree, minty and woody undertones. Accordingly, the formulation of Example XXI(B) can be described as "Chypre having sauge sclaree, minty and woody" undertones.
The compound having the structure: ##STR272## imparts to this Chypre formulation, fruity, herbaceous, celery-like and citrusy topnotes with fruity, floral, jasmine, lily of the valley, green and herbaceous undertones. Accordingly, the perfume formulation of Example XXI(C) can be described as "Chypre having fruity, herbaceous, celery-like and citrusy" topnotes with fruity, floral, jasmine, lily of the valley, green and herbaceous" undertones.
The compound having the structure: ##STR273## prepared according to Example IV imparts to this Chypre formulation, fresh, clean, tangerine-like, fruity and jasmine undertones with galbanum, jasmine, celery-like, green and pineapple" topnotes. Accordingly, the perfume formulation of Example XXI(D) can be described as "Chypre having fresh, clean, tangerine-like, fruity and jasmine" undertones and galbanum, jasmine, celery-like, green and pineapple" topnotes.
EXAMPLE XXII
Preparation of Cosmetic Powder Compositions
Cosmetic powder compositions are prepared by mixing in a ball mill 100 grams of talcum powder with 0.25 grams of each of the substances set forth in Table III below. Each of the cosmetic powder compositions has an excellent aroma as described in Table III below:
TABLE III______________________________________Substance Aroma Description______________________________________The compound having A green,the structure: herbaceous, parsley, ##STR274## rose, fruity, spicy, earthy and rooty aroma profile.prepared accordingto Example I.The compound having A sauge sclaree,the structure: minty and woody ##STR275## aroma profile.prepared accordingto Example II.The compound having A fruity,the structure: herbaceous, celery- ##STR276## like and citrusy aroma profile with fruity, floral, green, jasmine, lily of the valley, green and herbaceous undertones.prepared accordingto Example III.The compound having A fresh, clean,the strucure: tangerine-like, ##STR277## fruity, jasmine aroma with galbanum, jasmine, celery-like, green and pineapple topnotes.prepared accordingto Example IV.The compound having A green,the structure: herbaceous and ##STR278## woody aroma with floral undertones.prepared accordingto Example V.The compound having A spicy, dill,the structure: caraway and ##STR279## herbaceous aroma profile with animalic, dill and caraway undertones.prepared accordingto Example VI.The compound having A nutty, coconutthe structure: aroma with ##STR280## cinnamon and pineapple topnotes and floral and herbaceous undertones.prepared accordingto Example VII.The compound having A spicy aroma withthe structure: oak moss topnotes. ##STR281##prepared accordingto Example VIII.The compound having A fruity,the structure: herbaceous, floral ##STR282## aroma with citrusy, herbaceous and floral undertones.prepared accordingto Example IX.The compound having A fruity, peach,the structure: coconut-like aroma ##STR283## with almond oil topnotes.prepared accordingto Example X.The compound having A fresh, ozoney,the structure: seashore aroma with ##STR284## animalic topnotes.prepared accordingto Example XI.The compound having A caramel, maplethe structure: syrup aroma with ##STR285## green, herbaceous topnotes.prepared accordingto Example XII.The compound having A minty, woody,the structure: green and ##STR286## herbaceous aroma profile with camphoraceous, eucalyptus-like topnotes.prepared accordingto Example XIII.The compound having A citrusy,the structure: grapefruit, ##STR287## nootkatone-like aroma profile.prepared accordingto Example XIV.The compound having A green,the structure: herbaceous aroma ##STR288## with animalic undertones.prepared accordingto Example XV.The compound having A new mown haythe structure: aroma with green, ##STR289## herbaceous and straw-like undertones.prepared accordingto Example XVI.The compound having A jasmine aroma.the structure: ##STR290##prepared accordingto Example XVII.The compound having A fruity, peach-like,the structure: apricot and jasmine ##STR291## aroma profile.prepared accordingto Example XVIII.The compound having A woody, citrusy,the structure: mandarin, orange ##STR292## peel, floral and herbaceous and basil aroma profile with sweet, citrus, bergamot and floral undertones.prepared accordingto Example XIX.The compound having A herbaceous, plumthe structure: aroma with fresh, ##STR293## ozoney undertones.prepared accordingto Example XX.Perfume composition Chypre having aof Example XXI(A). green, herbaceous, parsley, rose, fruity, spicy, earthy and rooty undertones.Perfume composition Chypre havingof Example XXI(B). sauge sclaree, minty and woody undertones.Perfume composition Chypre havingof Example XXI(C). fruity, herbaceous, celery-like and citrusy topnotes with fruity, floral, jasmine, lily of the valley, green and herbaceous undertones.Perfume composition Chypre havingof Example XXI(D). fresh, clean, tangerine-like, fruity and jasmine undertones and galbanum, jasmine, celery-like, green and pineapple topnotes.______________________________________
EXAMPLE XXIII
Perfumed Liquid Detergents
Concentrated liquid detergents (Lysine salt of n-dodecylbenzene sulfonic acid as more specifically described in U.S. Pat. No. 3,948,818 issued on Apr. 6, 1976) with aroma nuances as set forth in Table III of Example XXII are prepared containing 0.10%, 0.15%, 0.20%, 0.25%, 0.30% and 0.35% of the substance set forth in Table III of Example XXII. They are prepared by adding and homogeneously mixing the appropriate quantity of substance set forth in Table III of Example XXII in the liquid detergent. The detergents all possess excellent aromas as set forth in Table III of Example XXII, the intensity increasing with greather concentrations of substance as set forth in Table III of Example XXII.
EXAMPLE XXIV
Preparation of Colognes and Handkerchief Perfumes
Compositions as set forth in Table III of Example XXII are incorporated into colognes at concentrations of 2.0%, 2.5%, 3.0%, 3.5%, 4.0%, 4.5% and 5.0% in 80%, 85%, 90% and 95% aqueous food grade ethanol solutions; and into handkerchief perfumes at concentrations of 15%, 20%, 25% and 30% (in 80%, 85%, 90% and 95% aqueous food grade ethanol solutions). Distinctive and definitive fragrances as set forth in Table III of Example XXII are imparted to the colognes and to the handkerchief perfumes at all levels indicated.
EXAMPLE XXV
Preparation of Soap Compositions
One hundred grams of soap chips [per sample] (IVORY.RTM., produced by the Procter & Gamble Company of Cincinnati, Ohio), are each mixed with one gram samples of substances as set forth in Table III of Example XXII until homogeneous compositions are obtained. In each of the cases, the homogeneous compositions are heated under 8 atmospheres pressure at 180.degree. C. for a period of three hours and the resulting liquids are placed into soap molds. The resulting soap cakes, on cooling, manifest aromas as set forth in Table III of Example XXII.
EXAMPLE XXVI
Preparation of Solid Detergent Compositions
Detergents are prepared using the following ingredients according to Example I of Canadian Patent No. 1,007,948:
______________________________________Ingredient Percent By Weight______________________________________"NEODOL .RTM. 45-11" 12(a C.sub.14 -C.sub.15 alcoholethoxylated with 11 molesof ethylene oxide)Sodium carbonate 55Sodium citrate 20Sodium sulfate, water brighteners q.s.______________________________________
This detergent is a phosphate-free detergent. Samples of 100 grams each of this detergent are admixed with 0.10, 0.15, 0.20 and 0.25 grams of each of the substances as set forth in Table III of Example XXII. Each of the detergent samples has an excellent aroma as indicated in Table III of Example XXII.
EXAMPLE XXVII
Utilizing the procedure of Example I at column 15 of U.S. Pat. No. 3,632,396, non-woven cloth substrates useful as dry-added fabric softening articles of manufacture are prepared wherein the substrate, the substrate coating and the outer coating and the perfuming material are as follows:
1. A water "dissolvable" paper ("Dissolvo Paper");
2. Adogen 448 (m.p. about 140.degree. F.) as the substrate coating; and
3. An outer coating having the following formulation (m.p. about 150.degree. F.):
15%-C.sub.20-22 HAPS
22%-isopropyl alcohol
20%-antistatic agent
1%-of one of the substances as set forth in Table III of Example XXII.
Fabric softening compositions prepared according to Example I at column 15 of U.S. Pat. No. 3,632,396 having aroma characteristics as set forth in Table III of Example XXII, consist of a substrate coating having a weight of about 3 grams per 100 square inches of substrate; a first coating on the substrate coating consisting of about 1.85 grams per 100 square inches of substrate; and an outer coating coated on the first coating consisting of about 1.4 grams per 100 square inches of substrate. One of the substances of Table III of Example XXII is admixed in each case with the outer coating mixture, thereby providing a total aromatized outer coating, the weight ratio to substrate of about 0.5:1 by weight of the substrate. The aroma characteristics are imparted in a pleasant manner to the head space in a dryer on operation thereof in each case using said dryer-added fabric softener non-woven fabrics aand these aroma characteristics are described in Table III of Example XXII.
EXAMPLE XXVIII
Hair Spray Formulations
The following hair spray formulation is prepared by first dissolving PVP/VA E-735 copolymer manufactured by the GAF Corporation of 140 West 51st Street, New York, N.Y., in 91.62 grams of 95% food grade ethanol, 8.0 grams of the polymer is dissolved in the alcohol. The following ingredients are added to the PVP/VA alcoholic solution:
______________________________________Ingredients Weight Percent______________________________________Dioctyl sebacate 0.05Benzyl alcohol 0.10Dow Corning 473 fluid 0.10(prepared by the Dow CorningCorporation)Tween 20 surfactant 0.03(prepared by ICI AmericaCorporation)One of the perfumery 0.10substances as setforth in Table III ofExample XXII.______________________________________
The perfuming substances as set forth in Table III of Example XXII add aroma characteristics as set forth in Table III of Example XXII which are rather intense and aesthetically pleasing to the users of the soft-feel, good-hold pump hair sprays.
EXAMPLE XXIX
Conditioning Shampoos
Monoamid CMA (prepared by the Mona Industries Company) (3.0 weight percent) is melted with 2.0 weight percent coconut fatty acid (prepared by Procter & Gamble Company of Cincinnati, Ohio); 1.0 weight percent ethylene glycol distearate (prepared by the Armak Corporation) and triethanolamine (a product of Union Carbide Corporation) (1.4 weight percent). The resulting melt is admixed with Stepanol WAT produced by the Stepan Chemical Company (35.0 weight percent). The resulting mixture is heated to 60.degree. C. and mixed until a clear solution is obtained (at 60.degree. C.).
GAFQUAT.RTM.755N polymer (manufactured by GAF Corporation of 140 West 51st Street, New York, N.Y.) (5.0 weight percent) is admixed with 0.1 weight percent sodium sulfite and 1.4 weight percent polyethylene glycol 6000 distearate produced by Armak Corporation.
The resulting material is then mixed and cooled to 45.degree. C. and 0.3 weight percent of perfuming substance as set forth in Table III of Example XXII is added to the mixture. The resulting mixture is cooled to 40.degree. C. and blending is carried out for an additional one hour in each case. At the end of this blending period, the resulting material has a pleasant fragrance as indicated in Table III of Example XXII.
EXAMPLE XXX
Four drops of each of the substances as set forth in Table III of Example XXII, supra, is added separately to two grams of AROMOX.RTM. DMC-W to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable, single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry, on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor, but does have a faint pleasant aroma as set forth in Table III of Example XXII. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE XXXI
AROMOX.RTM. DMMC-W in various quantities is mixed with 0.1 grams of one of the substances set forth in Table III of Example XXII, supra. The resulting premixes are then added to 200 grams of an aqueous 5% sodium hypochlorite solution. Sufficient 12.5M aqueous NaOH is added to bring the pH of the mixture up to 13. The following results are obtained:
______________________________________ Clarity of HypochloritePercentage AROMOX .RTM. Solution after additionDMMC-W of Premix______________________________________0.23% Clear after three days0.15% Clear after three days0.08% Initially slightly turbid; two phases exist after three days.______________________________________
When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out, in an atmosphere of 65% relative humidity, yields substantially no characteristic "hypochlorite" odor, but does have a faint, pleasant aroma as set forth in Table III of Example XXII. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and dry states.
EXAMPLE XXXII
Two grams of AROMOX.RTM. DMMC-W is admixed with eight drops of one of the substances set forth in Table III of Example XXII, supra. The premix is then added with stirring to 200 grams of a 7% aqueous solution of lithiumn hypochlorite. Sufficient 3M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at the temperature with stirring for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry, on dry-out in an atmosphere of 50% relative humidity retains a "clean" warm aroma as set forth in Table III of Example XXII, supra; whereas without the use of the substance set forth in Table III of Example XXII, supra, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XXXIII
Two grams of AROMOX.RTM. DMMC-W is admixed with eight drops of one of the substances of Table III of Example XXII, supra. This premix is then added, with stirring to 200 grams of a mixture containing 4.5% aqueous sodium hypochlorite. Sufficient 4M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintaining at that temperature for a period of one week. The resulting solution remains clear in a single phase. when used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity retains a "clean fresh" warm aroma as set forth in Table III of Example XXII, supra; whereas without the use of the substance set forth in Table III of Example XXII, supra, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XXXIV
Two grams of AROMOX.RTM. DMMC-W is admixed with eight drops of one of the substances as set forth in Table III of Example XXII, supra. This premix is then added with stirring to 200 grams of a mixture containing 4.5% aqueous sodium hypochlorite and 4.5% aqueous lithium hypochlorite. Sufficient 2M aqueous NaOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 110.degree. F. and maintained at that temperature with stirring for a period of 2 weeks. The resulting solution remains clear as a single phase when used as a laundry bleach. The resulting laundry bleach, on dry-out in an atmosphere of 50% relative humidity, retains an aroma as set forth in Table III of Example XXII, supra, whereas without the use of the substance set forth in Table III of Example XXII, supra, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XXXV
Four drops of one of the substances set forth in Table III of Example XXII, supra, is added to 1.5 grams of AROMOX.RTM. to produce a clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of 7 days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have a faint pleasant warm, long-lasting aroma as set forth in Table III of Example XXII, supra. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and dry states.
EXAMPLE XXXVI
Four drops of one of the substances set forth in Table III of Example XXII, supra, is added to 1 gram n-undecyl dimethyl amine oxide to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of 7 days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have a faint pleasant warm aroma as set forth in Table III of Example XXII, supra. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE XXXII
Four drops of one of the substances as set forth in Table III of Example XVII, supra, are added to 1 gram of n-dedecyl dimethyl amine oxide to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear, stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of 7 days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" aroma, but does have a warm, pleasant, long-lasting aroma as set forth in Table III of Example XVII, supra. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and dry states.
EXAMPLE XXXVIII
One gram of n-tridecyl dimethyl amine oxide is admixed with eight drops of one of the substances as set forth in Table III of Example XVII, supra. This premix is then added with stirring to 200 grams of a 7% aqueous solution of lithium hypochlorite. Sufficient 3M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature with stirring for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity retains a warm, fresh aroma described in Table III of Example XVII, supra, whereas without the use of one of the substances of Table III of Example XVII, supra, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XXXIX
One gram of n-tridecyl dimethyl amine oxide is admixed with eight drops of one of the substances as set forth in Table III of Example XXII, supra. This premix is then added with stirring to 200 grams of a 7% aqueous solution of lithium hypochlorite. Sufficient 3M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature with stirring for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity retains a warm, fresh aroma described in Table III of Example XXII, supra, whereas without the use of one of the substances of Table III of Example XXII, supra, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XL
AROMOX.RTM. DMMC-W in various quantities is mixed with 0.1 grams of the compound having the structure: ##STR294## prepared according to Example XI. The resulting premix is then added to 200 grams of an aqueous 5% sodium hypochlorite solution. Sufficient 12.5M aqueous NaOH is added to bring the pH of the mixture up to 13.
The following results are obtained:
______________________________________Percentage Clarity of Hypochlorite SolutionAROMOX .RTM. DMMC-W After Addition of Premix______________________________________0.23% Clear after three days.0.15% Clear after three days.0.08% Initially slightly turbid; two phases exist after three days.______________________________________
When the 5% aqueous sodium hypochlorite solutions are used as laundry bleaches, the resulting laundry batches on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor, but have fresh, ozoney, seashore aromas. Furthermore, no such characteristics "hypochlorite" aroma is retained on the hands of the individual handling such laundry batches in both the wet and the dry states.
EXAMPLE XLI
Two grams of AROMOX.RTM. DMMC-W are admixed with eight drops of the the compound having the structure: ##STR295## prepared according to Example XI. The premix is then added with stirring to 200 grams of a 7% aqueous solution of lithium hypochlorite. Sufficient 3M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixtures are then heated to 120.degree. F. and maintained at that temperature with stirring for a period of one week. The resulting solution remains clear in a single phase. When used as laundry bleaches, the resulting bleached laundry batches on dry-out in an atmosphere of 50% relative humidity retain a fresh, ozoney, seashore aroma; whereas without the compound having the structure: ##STR296## prepared according to Example XI, the bleached laundry batches have a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XLII
Two grams of AROMOX.RTM. DMMC-W are admixed with eight drops of the compound having the structure: ##STR297## prepared according to Example XI. The premix is then added with stirring to 200 grams of a mixture containing 4.5% aqueous sodium hypochlorite and 4.5% aqueous lithium hypochlorite, Sufficient 4M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry batches on dry-out in an atmosphere of 50% relative humidity retain a fresh, ozoney, seashore aroma; whereas without the use of the the compound having the structure: ##STR298## prepared according to Example XI, the bleached laundry dry batches having faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XLIII
Two grams of AROMOX.RTM. DMMC-W are admixed with eight drops of either (a) the the compound having the structure: ##STR299## prepared according to Example XI; or (b) a 50-50 mixture of the compound having the structure: ##STR300## prepared according to Example XI, and diisoamylene epoxide produced according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981, the disclosure of which is incorporated herein by reference. These premixes are then added with stirring to 200 grams of a mixture containing 4% aqueous sodium hypochlorite and 4% aqueous lithium hypochlorite. Sufficient 2M aqueous NaOH is added to bring the pH of the solutions to 13.4. The mixtures are then heated to 110.degree. F. and maintained at that temperature with stirring for a period of two weeks. The resulting solutions remain clear as a single phase when used as laundry bleaches. The resulting bleached laundry batches on dry-out in an atmosphere of 50% relative humidity retain either a "fresh, ozoney, seashore" aromas (when using the the compound having the structure: ##STR301## prepared according to Example XI, or retain fresh, ozoney, seashore aromas, when using the mixture of the diisoamylene epoxide and the compound having the structure: ##STR302## prepared according to Example XI; whereas without the use of the compound having the structure: ##STR303## prepared according to Example XI, containing compositions of matter the bleached laundry batches have faint characteristic disagreeable "hypochlorite" aromas.
EXAMPLE XLIV
Four drops of the compound having the structure: ##STR304## prepared according to Example XI, are added to 1.5 grams of AROMOX.RTM. NCMD-W to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE XLV
Four drops of the compound having the structure: ##STR305## prepared according to Example XI, is added to 1 gram of n-undecyl dimethyl amine oxide to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture to 12.8. The solution remains sbstantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have a "fresh, ozoney, seashore" aroma. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE XLVI
One drop of n-tridecyl dimethyl amine oxide is admixed with eight drops of a 50:50 mixture of the diisoamylene epoxide prepared according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and the compound having the structure: ##STR306## prepared according to Example XI, supra. This premix is then added with stirring to 200 grams of a 7% aqueous solution of lithium hypochlorite. Sufficient 3M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature with stirring for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity retains a "fresh, ozoney, seashore" aroma; whereas without the use of the mixture of diisoamylene epoxide and the compound having the structure: ##STR307## prepared according to Example XI, bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XLVII
AROMOX.RTM. DMMC-W in various quantities is mixed with 0.1 gram of a 25:75 weight:weight mixture of diisoamylene epoxide: ##STR308## prepared according to Example XI.
The resulting premixes are then added to 200 grams of an aqueous 5% sodium hypochlorite solution. Sufficient 12.5M aqueous NaOH is added to bring the pH of the mixture up to 13. The following results are obtained:
______________________________________Percentage Clarity of Hypochlorite SolutionAROMOX .RTM.DMMC-W After Addition of Premix______________________________________0.23% Clear after three days.0.15% Clear after three days.0.08% Initially slightly turbid: two phases exist after three days.______________________________________
When used as laundry bleaches, the resulting bleached laundries on dry-out in an atmosphere of 50% relative humidity in each of the three cases above retain a "fresh, ozoney, seashore aroma", whereas without the use of the composition of matter set forth above containing diisoamylene epoxide and the compound having the structure: ##STR309## prepared according to Example XI, the bleached laundry has the same characteristic disagreeable "hypochlorite" aroma.
EXAMPLE XLVIII
DOWFAX.RTM. 2A1 (see Note 1, infra) in various quantities, as set forth below, is mixed with 0.1 grams of a 50:50 mixture of (a) one of the diisoamylene epoxide compositions prepared according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and (b) the compound having the structure: ##STR310## prepared according to Example XI. The resulting premixes are then added to 200 grams of an aqueous 7% sodium hypochlorite solution. Sufficient 12.5M aqueous sodium hydroxide is added to bring the pH of the mixture up to 13.5. The following results are obtained:
______________________________________Percentage of Clarity of Hypochlorite SolutionDOWFAX .RTM. 2Al After Addition of Premix______________________________________0.23% Clear after seven days.0.15% Clear after five days.0 08% Clear after three days.0.01% Initially slightly turbid: two phases exist after three days.______________________________________
EXAMPLE XLIX
Four drops of a 25:75 weight/weight mixture of diisoamylene epoxide prepared according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 and the compound having the structure: ##STR311## prepared according to Example XI, supra, is added to grams of DOWFAX.RTM. 3B2 and 0.5 grams of AROMOX.RTM. DMC-W to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture of 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor a but does have a fresh, ozoney, seashore aroma. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE L
One gram of DOWFAX.RTM. 3B2; one gram of DOWFAX.RTM. 2A1 and 0.25 grams of AROMOX.RTM. DMMC-W is admixed with eight drops of the compound having the structure: ##STR312## prepared according to Example XI. This premix is then added, with stirring to 200 grams of a mixture containing 4.5% aqueous sodium hypochlorite and 4.5% aqueous lithium hypochlorite. Sufficient 4M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature for a period of one week. The resulting solution remains clear in a single pase. When used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity reatins a fresh, ozoney, seashore aroma; whereas without the use of the compound having the structure: ##STR313## prepared according to Example XI, supra, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE LI
One gram of DOWFAX.RTM. 2A1 and one gram of DOWFAX.RTM. 3B2 is admixed with weight drops of a 50:50 mixture of one of the diisoamylene epoxide compositions of Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and the compound having the structure: ##STR314## prepared according to Example XI. This premix is then added, with stirring to 200 grams of a mixture containing 4.5% aqueous sodium hypochlorite. Sufficient 4M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity remains a fresh, ozoney, seashore aroma; whereas without the use of the perfume composition which is a mixture of diisoamylene epoxide and the compound having the structure: ##STR315## prepared according to Example XI, the bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE LII
Four drops of a 50:50 mixture of one of the diisoamylene epoxide mixtures produced according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and the compound having the structure: ##STR316## prepared according to Example XI, supra, is added to 1.0 grams of DOWFAX.RTM. 3B2 and 0.25 grams of AROMOX.RTM. NCMD-W to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor, but does have a fresh, ozoney, seashore aroma. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE LIII
Four drops of the compound having the structure: ##STR317## prepared according to Example XI is added to 0.1 grams n-undecyl dimethyl amine oxide and 0.9 grams of DOWFAX.RTM. 3B2 to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor, but does have a fresh, ozoney, seashoe aroma. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE LIV
Four drops of a 50:50 mixture of diisoamylene epoxide produced according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and the compound having the structure: ##STR318## prepared according to Example XI, supra, is added to 0.1 gram of n-dodecyl dimethyl amine oxide and 0.9 grams of DOWFAX.RTM. 2A1 to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE LV
0.2 Grams of n-tridecyl dimethyl amine oxide and 0.7 grams of DOWFAX.RTM. 3B2 are admixed with eight drops of the compound having the structure: ##STR319## prepared according to Example XI, supra. This premix is then added with stirring to 200 grams of a 7% aqueous solution of lithium hypochlorite. Sufficient 3M aqueous LiOH is added to bring the pH of the solution to 13.4. The mixture is then heated to 120.degree. F. and maintained at that temperature with stirring for a period of one week. The resulting solution remains clear in a single phase. When used as a laundry bleach, the resulting bleached laundry on dry-out in an atmosphere of 50% relative humidity retains a fresh, ozoney, seashore aroma; whereas without the use of the compound having the structure: ##STR320## prepared according to Example XI, bleached laundry has a faint characteristic disagreeable "hypochlorite" aroma.
EXAMPLE LVI
A mixture is prepared consisting of 39 grams of DOWFAX.RTM. 2A1 (60.75%); 4.5 grams of sodium palmitate (7.00%); and 20.7 grams of water (32.25%). The mixture is heated while stirring followed by ultrasonic dispersion thereby yielding a homogeneous gel. 64.2 Grams of this material is used as follows: 4 drops of the compound having the structure: ##STR321## prepared according to Example XI is added to 2.0 grams of the foregoing gel to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE LVII
A mixture is prepared consisting of 39 grams of DOWFAX.RTM. 2A1 (60.75); 4.5 grams sodium laurate (7.00%); and 20.7 grams of water (32.25%). The mixture is heated while stirring followed by ultrasonic dispersion thereby yielding a homogeneous gel. 64.2 Grams of this material is used as follows: 4 drops of (a) one of the diisoamylene epoxide mixtures produced according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and (b) the compound having the structure: ##STR322## prepared according to Example XI, supra, is added to 2.0 grams of the foregoing gel to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE LVIII
A mixture is prepared consisting of 20.1 grams DOWFAX.RTM.2A1 (60.75%); 2.0 grams of sodium palmitate (7.00%); and 20.0 grams of water (32.25%). The mixture is heated while stirring followed by ultrasonic dispersion thereby yielding a homogeneous gel. 64.2 Grams of this material is used as follows: 4 drops of the compound having the structure: ##STR323## prepared according to Example XI, supra, is added to 2.0 grams of the foregoing gel to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous medium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out is an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
EXAMPLE LIX
A mixture is prepared consisting of 10 grams of DOWFAX.RTM.2A1 and 10 grams of DOWFAX.RTM.3B1 (60.75); and 2.0 grams of sodium laurate (7.00%); and 20.0 grams of water (32.25%). The mixture is heated while stirring followed by ultrasonic dispersion thereby yielding a homogeneous gel. 64.2 Grams of this material is used as follows: 4 drops of the compound having the structure: ##STR324## prepared according to Example XI, supra, is added to 2.0 grams of the foregoing gel to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out is an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have a fresh, ozoney, seashore aroma. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the day states.
EXAMPLE LX
A mixture is prepared consisting of 60 grams of AROMOX.RTM. DMMC-W, 30 grams DOWFAX.RTM.2A1; 6.0 grams lauric acid; 9.0 grams KOH; and 500 grams water. The mixture is heated while stirring followed by ultrasonic dispersion thereby yielding a homogeneous gel. 64.2 Grams of this material is used as follows: 4 drops ofthe compound having the structure: ##STR325## prepared according to Example XI, is added to 2.0 grams of the foregoing gel to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.
It is noteworthy that the viscosity of the solution subsequent to heating is 26.75 centiposies.
EXAMPLE LXI
A mixture is prepared consisting of 60 grams of AROMOX.RTM. DMMC-W, 21 grams of DOWFAX.RTM.2A1; 3.6 grams of lauric acid; 10.5 grams of KOH and 508 grams of water. The mixture is heated while stirring followed by ultrasonic dispersion thereby yielding a homogeneous gel having a viscosity of 23.45 centipoises. 64.2 Grams of this material is used as follows: 4 drops of a 50:50 mixture of (a) one of the diisoamylene epoxide mixtures produced according to Example II of application for U.S. Letters Patent, Ser. No. 277,131 filed on June 25, 1981 and (b) the compound having the structure: ##STR326## prepared according to Example XI, supra, is added to 2.0 grams of the foregoing gel to produce a clear premix. The clear premix is added to 200 grams of CLOROX.RTM. with stirring resulting in a clear stable single phase solution. Sufficient 1M aqueous NaOH is added to bring the pH of the mixture up to 12.8. The solution remains substantially stable at 120.degree. F. for a period of seven days. When the 5% aqueous sodium hypochlorite solution is used as a laundry bleach, the resulting laundry on dry-out in an atmosphere of 65% relative humidity yields substantially no characteristic "hypochlorite" odor but does have fresh, ozoney, seashore aromas. Furthermore, no such characteristic "hypochlorite" aroma is retained on the hands of the individual handling such laundry in both the wet and the dry states.

Number	Name	Date
3681263	van der Linde et al.	Aug 1972
4010286	Hall et al.	Apr 1977
4057515	Boelens et al.	Nov 1977
4070491	Vinals et al.	Jan 1978
4071034	Vinals et al.	Jan 1978
4071535	Vinals et al.	Jan 1978
4115406	Vinals et al.	Sep 1978
4120830	Renold et al.	Oct 1978
4186103	Hall et al.	Jan 1980
4192782	Hall et al.	Mar 1980
4240447	Hall et al.	Dec 1980

Number	Date	Country
618374	Aug 1978	SUX
620487	Aug 1978	SUX
638597	Dec 1978	SUX

2,4-disubstituted and 2,2,4-trisubstituted tetrahydropyranyl-4-ethers, process for preparing same and perfumery uses thereof

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