Claims
- 1. A thiazolidinedione derivative of the formula: ##STR8## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydrogen or a lower alkyl group; R.sup.3 is hydrogen or formyl, alkylcarbonyl having 2 to 6 carbon atoms, phenylacetyl,phenylpropionyl, benzoyl or p-toluoyl; n is 0 or 1 or a pharmaceutical acid addition salt or a base salt thereof.
- 2. A blood sugar-and lipid-lowering composition which contains an effective amount of a thiazolidinedione derivative of the formula: ##STR9## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydrogen or a lower alkyl group; R.sup.3 is hydrogen or formyl, alkylcarbonyl having 2 to 6 carbon atoms, phenylacetyl, phenylpropionyl, benzoyl or p-toluoyl; n is 0 or 1 or a pharmaceutical acid addition salt or a pharmaceutical base salt thereof.
- 3. The compound as claimed in claim 1, wherein n is zero.
- 4. The compound as claimed in claim 1, wherein R.sup.3 is hydrogen.
- 5. The compound as claimed in claim 1, wherein the compound is 5-{4-[2-(5-ethyl-2-pyridyl)-2-hydroxyethoxy]benzyl}-2,4-thiaxolidinedione.
- 6. The compound as claimed in claim 1, wherein the compound is 5-{4-[2-hydroxy-2-(2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione.
- 7. The compound as claimed in claim 1, wherein the compound is 5-{4-[2-hydroxy-2-(6-methyl-2-pyridyl)ethoxyl]benzyl}-2,4-thiazolidinedione.
- 8. The compound as claimed in claim 1, wherein the compound is 5-{4-[2-hydroxy-2-(3-methyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione
Parent Case Info
This is a continuation-in-part of Ser. No. 624,689, filed June 11, 1984, now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP84/00445 |
9/21/1984 |
|
|
3/7/1985 |
3/7/1985 |
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4287200 |
Kawamatsu et al. |
Sep 1981 |
|
4340605 |
Kawamatsu |
Jul 1982 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0084926 |
Aug 1983 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Sohda et al, "Studies on Anti Diabetic Agents", Chem. Pharm. Bull., Chem. Abs. 98:160624h. |
Kawamatsu et al, "Thiazolidine Derivatives", Chem. Abs. 93:114506v. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
624689 |
Jun 1984 |
|