2,5-Inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-6-iodo-PGF.sub.1 compounds

Abstract

The present invention provides 2,5-inter-o-phenylene-3,4-dinor-6,9.alpha.-epoxy-6.beta.-6-iodo-PGF.sub.1 compounds. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological purposes, e.g., as antithrombotic agents.

Description

BACKGROUND OF THE INVENTION

The present invention relates to novel prostacyclin analogs and intermediates for their production. In particular, the present invention relates to prostacyclin intermediates useful in the production of 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs. Most particularly the present invention provides 2,5-inter-o-phenylene-3,4-dinor-5,9.alpha.-epoxy-6-iodo-PGF.sub.1 compounds. The preparation and use of the novel compounds described herein is incorporated here by reference U.S. Pat. No. 4,281,113.

SUMMARY OF THE INVENTION

The present invention particularly provides a prostacyclin intermediate of formula IX ##STR1## wherein R.sub.28 is --OR.sub.10, --CH.sub.2 OR.sub.10, hydroxy, hydroxymethyl, or hydrogen, wherein R.sub.10 is a blocking group removable by mild acidic hydrolysis;

wherein Y.sub.1 is (1) trans--CH.dbd.CH--, (2) cis--CH.dbd.CH--, (3) --CH.sub.2 CH.sub.2 --, or (4) --C.tbd.C--, wherein M.sub.8 is .alpha.-R.sub.5 :.beta.-OR.sub.10 or .alpha.-OR.sub.10 :.beta.-R.sub.5, wherein R.sub.5 is hydrogen or methyl and R.sub.10 is as defined above, or .alpha.-R.sub.5 :.beta.-OH or .alpha.-OH:.beta.-R.sub.5, wherein R.sub.5 is as defined above; wherein L.sub.1 is .alpha.-R.sub.3 :.beta.-R.sub.4, .alpha.-R.sub.4 :.beta.-R.sub.3, or a mixture of .alpha.-R.sub.3 :.beta.-R.sub.4 and .alpha.-R.sub.4 -.beta.-R.sub.3, wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro; wherein R.sub.7 is (1) --(CH.sub.2).sub.m --CH.sub.3, wherein m is an integer from one to 5, inclusive; (2) phenoxy; (3) phenoxy substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl; (4) phenyl; (5) phenyl substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl; (6) phenylmethyl, phenylethyl, or phenylpropyl; or (7) phenylmethyl, phenylethyl, or phenylpropyl substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl; with the proviso that R.sub.7 is phenoxy or substituted phenoxy, only when R.sub.3 and R.sub.4 are hydrogen or methyl, being the same or different; wherein R.sub.1 is (1) hydrogen; (2) alkyl of one to 12 carbon atoms, inclusive; (3) cycloalkyl of 3 to 10 carbon atoms, inclusive; (4) aralkyl of 7 to 12 carbon atoms, inclusive; (5) phenyl; (6) phenyl substituted with one, 2 or 3 chloro or akyl of one to 3 carbon atoms; or (7) phenyl substituted in the para position by (a) --NH--CO--R.sub.25 (b) --CO--R.sub.26 (c) --O--CO--R.sub.27 (d) --CH.dbd.N--NH--CO--NH.sub.2 wherein R.sub.25 is methyl, phenyl, acetamidophenyl, benzamidophenyl, or --NH.sub.2 ; R.sub.26 is hydrogen, methyl, phenyl, --NH.sub.2, or methoxy; and R.sub.27 is phenyl or acetamidophenyl, inclusive, or a pharmacologically acceptable salt thereof when R.sub.1 is hydrogen.

The novel prostaglandin analogs prepared from the above intermediates are useful for a variety of prostacyclin-like pharmacological purposes, particularly and especially as inhibitors of platelet aggregation in vivo and in vitro. Thus, these prostacyclin analogs are useful for a variety of pharmacological and therapeutical purposes, e.g., as antithrombotic agents.

Claims

1. A prostacyclin intermediate of formula IX ##STR2## wherein R.sub.28 is --OR.sub.10, --CH.sub.2 OR.sub.10, hydroxy, hydroxymethyl, or hydrogen, wherein R.sub.10 is a blocking group removable by mild acidic hydrolysis;

wherein Y.sub.1 is

(1) trans--CH.dbd.CH--,

(2) cis--CH.dbd.CH--,

(3) --CH.sub.2 CH.sub.2 --, or

(4) --C.tbd.C--,

wherein M.sub.8 is .alpha.-R.sub.5 :.beta.-OR.sub.10 or .alpha.-OR.sub.10 :.beta.-R.sub.5, wherein R.sub.5 is hydrogen or methyl and R.sub.10 is as defined above, or

.alpha.-R.sub.5 :.beta.-OH or .alpha.-OH:.beta.-R.sub.5, wherein R.sub.5 is as defined above;

wherein L.sub.1 is .alpha.-R.sub.3 :.beta.-R.sub.4, .alpha.-R.sub.4 :.beta.-R.sub.3, or a mixture of .alpha.-R.sub.3 :.beta.-R.sub.4 and .alpha.-R.sub.4 :.beta.-R.sub.3, wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;

wherein R.sub.7 is

(1) --(CH.sub.2).sub.m --CH.sub.3, wherein m is an integer from one to 5, inclusive;

(2) phenoxy;

(3) phenoxy substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl;

(4) phenyl;

(5) phenyl substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl;

(6) phenylmethyl, phenylethyl, or phenylpropyl; or

(7) phenylmethyl, phenylethyl, or phenylpropyl substituted by one, 2 or 3 chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, with the proviso that not more than two substituents are other than alkyl; with the proviso that R.sub.7 is phenoxy or substituted phenoxy, only when R.sub.3 and R.sub.4 are hydrogen or methyl, being the same or different;

wherein R.sub.1 is

(1) hydrogen;

(2) alkyl of one to 12 carbon atoms, inclusive;

(3) cycloalkyl of 3 to 10 carbon atoms, inclusive;

(4) aralkyl of 7 to 12 carbon atoms, inclusive;

(5) phenyl;

(6) phenyl substituted with one, 2 or 3 chloro or alkyl of one to 3 carbon atoms; or

(7) phenyl substituted in the para position by

(a) --NH--CO--R.sub.25

(b) --CO--R.sub.26

(c) --O--CO--R.sub.27

(d) --CH.dbd.N--NH--CO--NH.sub.2

wherein R.sub.25 is methyl, phenyl, acetamidophenyl, benzamidophenyl, or --NH.sub.2 ; R.sub.26 is hydroxy, methyl, phenyl, --NH.sub.2, or methoxy; and R.sub.27 is phenyl or acetamidophenyl, inclusive, or a pharmacologically acceptable salt thereof when R.sub.1 is hydrogen.