Claims
- 1. A compound of the formula: ##STR6## wherein R.sub.1 is selected from the group consistng of hydrogen and lower alkyl (C.sub.1 -C.sub.2) and R.sub.2 is selected from the group consisting of hydrogen and lower alkyl (C.sub.1 -C.sub.2) and pharmaceutically acceptable salts thereof.
- 2. The compound according to claim 1, 2,6-bis(piperidinomethyleneamino)anthraquinone.
- 3. The compound according to claim 1, 2,6-bis[(1-piperidinopropylidene)amino]anthraquinone.
- 4. The compound according to claim 1, 2,6-bis[(1-piperidinoethylidene)amino]anthraquinone.
- 5. The compound according to claim 1, 2,6-bis[1-(4-methyl-piperidinoethylidene)amino]anthraquinone.
- 6. A method of treating cecal and hepatic amebic infections in warm-blooded animals which comprises administering to said animals an amount effective against said infections of a compound of the formula: ##STR7## wherein R.sub.1 is selected from the group consisting of hydrogen and lower alkyl (C.sub.1 -C.sub.2) and R.sub.2 is selected from the group consisting of hydrogen and lower alkyl (C.sub.1 -C.sub.2) and pharmaceutically acceptable salts thereof.
- 7. The method according to claim 6 wherein the compound is 2,6-bis(piperidinomethyleneamino)anthraquinone.
- 8. The method according to claim 6 wherein the compound is 2,6-bis(1-piperidinopropylidene)amino anthraquinone.
- 9. The method according to claim 6 wherein the compound is 2,6-bis[(1-piperidinoethylidene)amino]anthraquinone.
- 10. The method according to claim 6, wherein the compound is 2,6-bis[1-(4-methyl-piperidinoethylidene)amino]anthraquinone.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of application Ser. No. 772,038, filed Feb. 25, 1977, now abandoned, which is a continuation-in-part of application Ser. No. 699,816, filed June 24, 1976, now abandoned, which is a division of application Ser. No. 606,805, filed Aug. 22, 1975, now abandoned.
U.S. Pat. No. 3,184,482 discloses a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or lower alkyl and R.sub.3, R.sub.4, and R.sub.5 are hydrogen, hydroxy or ##STR2## Utility is described as antibacterial antiviral, antiprotozoal and anthelmintic.
U.S. Pat. No. 3,654,319, Neeff, make a gratuitous disclosure of a compound of the formula: ##STR3## but the compound is neither claimed nor exemplified. Neeff does exemplify 1,4- and 1,5-diaminoanthraquinones of the following formulae: ##STR4## but Applicants have prepared these compounds and have found them to be inactive for the claimed utility.
This invention is concerned with novel compounds of the formula: ##STR5## wherein R.sub.1 is selected from the group consisting of hydrogen and lower alkyl (C.sub.1 -C.sub.4) and R.sub.2 is selected from the group consisting of hydrogen and lower alkyl (C.sub.1 -C.sub.2) and pharmaceutically acceptable salts thereof. This invention is also concerned with the method of treating cecal and hepatic amebic infections in warm-blooded animals with the disclosed compounds.
US Referenced Citations (2)
| Number |
Name |
Date |
Kind |
|
3184482 |
Steiger |
May 1965 |
|
|
3974186 |
Fleming et al. |
Aug 1976 |
|
Foreign Referenced Citations (1)
| Number |
Date |
Country |
| 2,521,357 |
Nov 1976 |
DEX |
Divisions (1)
|
Number |
Date |
Country |
| Parent |
606805 |
Aug 1975 |
|
Continuations (1)
|
Number |
Date |
Country |
| Parent |
772038 |
Feb 1977 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
| Parent |
699816 |
Jun 1976 |
|
Patent Grant
4118498
