Claims
- 1. A compound selected from those of formula; ##STR12## wherein R.sub.7 and R.sub.8 are independently selected from the group consisting of (C.sub.1 -C.sub.6)acyloxy, (C.sub.1 -C.sub.6)alkoxy, hydroxy, thio, (C.sub.1 -C.sub.6)alkylthio, (C.sub.1 -C.sub.6)alkyldithio with the proviso that one of R.sub.7 and R.sub.8 must be hydrogen.
- 2. The compound according to claim 1, (racemic)-N-[4-[3-(acetyloxy)-1-pyrrolidinyl]-2-butynyl]-N-methylacetamide
- 3. The compound according to claim 1, (racemic)-N-[4-(3-hydroxy-1-pyrrolidinyl)-2-butynyl]-N-methylacetamide.
- 4. The compound according to claim 1, (racemic)-N-[4-(3-methoxy-1-pyrrolidinyl)-2-butynyl]-N-methylacetamide.
- 5. The oxidative dimers of the compounds of claim 1, wherein any one of R.sub.7 or R.sub.8 may be thio.
- 6. A method of treating central cholinergic disfunction in a mammal which comprises administering to said mammal an effective amount of a compound selected from those of claim 1.
- 7. A pharmaceutical composition of matter in dosage unit form comprising from about 1 to about 5000 mg of a compound of claim 1 in association with a pharmaceutically acceptable carrier.
Parent Case Info
This is a divisional of co-pending application Ser. No. 300,447, filed on Jan. 23, 1989.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4243672 |
Barnish et al. |
Jan 1981 |
|
4536500 |
Bourgery et al. |
Aug 1985 |
|
4847284 |
Schwartz et al. |
Jul 1989 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
300447 |
Jan 1989 |
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