Claims
- 1. A compound of the formula ##STR21## where n is 0 or 1; A is ##STR22## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; m is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR23## or aryl except that when R.sub.1 is ##STR24## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkythio, cyano, amino or trifluoromethyl, or a pharmaceutically acceptable acid addition salt thereof.
- 2. The compound according to claim 1, where n=0.
- 3. The compound according to claim 1, where R.sub.1 =R.sub.2 =H.
- 4. The compound according to claim 1, where R.sub.1 +R.sub.2 =--(CH.sub.2).sub.4 --.
- 5. The compound according to claim 1, where R.sub.1 =R.sub.2 =CH.sub.3.
- 6. The compound according to claim 1, where ##STR25## where P is hydrogen, loweralkyl, loweralkoxy, hydroxy, loweralkylthio or amino and R.sub.2 is hydrogen.
- 7. The compound according to claim 1, where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl.
- 8. The compound according to claim 2, where R.sub.1 =R.sub.2 =H.
- 9. The compound according to claim 2, where R.sub.1 +R.sub.2 =--(CH.sub.2).sub.4 --.
- 10. The compound according to claim 2, where R.sub.1 =R.sub.2 =CH.sub.3.
- 11. The compound according to claim 2, where ##STR26## where P is hydrogen, loweralkyl, loweralkoxy, hydroxy, loweralkylthio or amino and R.sub.2 is hydrogen.
- 12. The compound according to claim 2, where R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl.
- 13. The compound according to claim 1, which is 3-[4-[1-(2-methylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 14. The compound according to claim 1, which is 3-[4-[1-(3-methylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 15. The compound according to claim 1, which is 3-[4-[1-(2,3-dimethylphenyl)-4-piperazinyl]butyl]-4.notident.-thiazolidinone.
- 16. The compound according to claim 1, which is 3-[4-[1-(2-methoxyphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 17. The compound according to claim 1, which is 3-[4-[1-(3-methylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 18. The compound according to claim 1, which is 3-[4-[1-(4-fluorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 19. The compound according to claim 1, which is 3-[4-[1-(2-chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 20. The compound according to claim 1, which is 3-[4-[1-(3-chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 21. The compound according to claim 1, which is 3-[4-[1-(4-chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 22. The compound according to claim 1, which is 3-[4-[1-(3-trifluoromethylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 23. The compound according to claim 1, which is 3-[4-[1-(2-methoxyphenyl)-4-piperazinyl]butyl]-1,4-dioxothiazolidine.
- 24. The compound according to claim 1, which is 3-[4-[1-(4-fluorophenyl)-4-piperazinyl]butyl]-1,4-dioxothiazolidinone.
- 25. The compound according to claim 1, which is 3-[4-[1-(2-methoxyphenyl)-4-piperazinyl]butyl]-2-methyl-4-thiazolidinone.
- 26. The compound according to claim 1, which is 3-[4-[1-(4-fluorophenyl)-4-piperazinyl]butyl]-2-methyl-4-thiazolidinone.
- 27. The compound according to claim 1, which is 3-[4-[1-(3-chlorophenyl)-4-piperazinyl]butyl]-2-methyl-4-thiazolidinone.
- 28. The compound according to claim 1, which is 3-[4-[1-(2-methoxyphenyl)-4-piperazinyl]butyl]-5-methyl-4-thiazolidinone.
- 29. The compound according to claim 1, which is 2,2-dimethyl-3-[4-[1-(3-methylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 30. The compound according to claim 1, which is 2,2-dimethyl-3-[4-[1-(2-methoxyphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 31. The compound according to claim 1, which is 2,2-dimethyl-3-[4-[1-(3-chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 32. The compound according to claim 1, which is 2,2-dimethyl-3-[4-[1-(3-trifluoromethylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 33. The compound according to claim 1, which is 2,2-dimethyl-3-[4-[1-(3-methylthiophenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 34. The compound according to claim 1, which is 5,5-dimethyl-3-[4-[1-(2-methoxyphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 35. The compound according to claim 1, which is 5,5-dimethyl-3-[4-[1-(3-trifluoromethylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 36. The compound according to claim 1, which is 5-phenyl-3-[4-[1-(3-trifluoromethylphenyl)-4-piperazinyl]butyl]-4-thiazolidinone.
- 37. The compound according to claim 1, which is 3-[4-[1-(3-trifluoromethylphenyl)-4-piperazinyl]butyl]-5,5-dimethyl-4-thiazolidinone.
- 38. The compound according to claim 1, which is 3-[4-[1-(2-methylphenyl)-4-piperazinyl]butyl]-5,5-dimethyl-4-thiazolidinone.
- 39. The compound according to claim 1, which is 3-[4-[1-(2,3-dimethylphenyl)-4-piperazinyl]butyl]-5,5-dimethyl-4-thiazolidinone.
- 40. The compound according to claim 1, which is 3-(4-(1-(3-methylphenyl)-4-piperazinyl)butyl)-5,5-dimethyl-4-thiazolidinone.
- 41. The compound according to claim 1, which is 3-(4-(1-[3-methylphenyl]-4-piperazinyl)butyl)-2,2,5,5-tetramethyl-4-thiazolidinone.
- 42. The compound according to claim 1, which is 3-(4-(1-(2-methoxyphenyl)-4-piperazinyl)butyl)-2,2,5,5-tetramethyl-4-thiazolidinone.
- 43. The compound according to claim 1, which is 3-(4-(1-(2-methoxyphenyl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one.
Parent Case Info
This is a continuation application of a prior application, Ser. No. 07/430,688 filed Oct. 31, 1989, now U.S. Pat. No. 4,933,453 which is a continuation-in-part application of a prior application Ser. No. 123,622, filed Nov. 20, 1987, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0125389 |
Nov 1976 |
JPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
430688 |
Oct 1989 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
123622 |
Nov 1987 |
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