Claims
- 1. A compound of the formula ##STR53## wherein R is hydrogen, R' is selected from the group consisting of alkenyl and alkynyl of 2 to 4 carbon atoms, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal, magnesium and a pharmaceutically acceptable organic amine base and the OR' group is in the syn position.
- 2. A compound of claim 1 wherein A is selected from the group consisting of hydrogen, sodium and an equivalent of diethylamine.
- 3. A compound of claim 1 which is the syn isomer of 3-acetoxymethyl-7(2-(2-amino-4-thiazolyl)-2-vinyloxyiminoacetamido)-ceph-3-eme-4-carboxylic acid.
- 4. A compound of claim 1 which is the sodium salt of the acid of claim 3.
- 5. A compound of claim 1 selected from the group consisting of the syn isomer of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-(2-propenyloxyimino)-acetamido)-ceph-3-eme-4-carboxylic acid and its alkali metal, alkaline earth metal, magnesium and pharmaceutically acceptable organic amine salts.
- 6. An antibiotic composition comprising an antibiotically effective amount of at least one compound of claim 1 and an inert pharmaceutical carrier.
- 7. A composition of claim 6 wherein A is selected from the group consisting of hydrogen and sodium.
- 8. A composition of claim 6 wherein the compound is the syn isomer of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl-2-vinyloxyiminoacetamido)-ceph-3-eme-4-carboxylic acid.
- 9. The composition of claim 6 wherein the compound is the sodium salt of the syn isomer of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-vinyloxyiminoacetamido)-ceph-3-eme-4-carboxylic acid.
- 10. The composition of claim 6 wherein the compound is the compound of claim 5.
- 11. A method of combatting bacterial infections in warm-blooded animals comprising administering to warm-blooded animals an antibacterially effective amount of at least one compound of claim 1.
- 12. A method of claim 11 wherein A is selected from the group consisting of hydrogen and sodium.
- 13. A method of claim 12 wherein the compound is selected from the group consisting of the syn isomer of 3-acetoxymethyl-7-(2-(2-amino-4-thiazolyl)-2-vinyloxyimino-acetamido)-ceph-3-eme-4-carboxylic acid and its sodium salt.
- 14. The method of claim 11 wherein the compound is selected from the group consisting of the syn isomer of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-vinyloxyiminoacetamido]-ceph-3-eme-4-carboxylic acid and the syn isomers of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-(2-propenyloxyimino)-acetamido]-ceph-3-eme-4-carboxylic acid and their alkali metal, alkaline earth metal, magnesium and pharmaceutically acceptable organic amine salts.
Priority Claims (5)
Number |
Date |
Country |
Kind |
76 01834 |
Jan 1976 |
FRX |
|
76 17743 |
Jun 1976 |
FRX |
|
76 25051 |
Aug 1976 |
FRX |
|
77 07307 |
Mar 1977 |
FRX |
|
77 22077 |
Jul 1977 |
FRX |
|
PRIOR APPLICATION
This application is a continuation-in-part of copending, commonly assigned U.S. patent application Ser. No. 817,114 filed July 19, 1977 now U.S. Pat. No. 4,152,432 (which in turn is a continuation-in-part of copending, commonly assigned U.S. patent application Ser. No. 761,270 filed Jan. 21, 1977 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3971778 |
Cook et al. |
Jul 1976 |
|
4098888 |
Ochiai et al. |
Jul 1978 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
817114 |
Jul 1977 |
|
Parent |
761270 |
Jan 1977 |
|