Claims
- 1. A compound of formula or a pharmaceutically acceptable salt thereof wherein:R1 is straight or branched alkyl of from 5 to 15 carbon atoms, aryl, or heteroaryl; R2 is hydroxy, amino, or thiol group; R3 is aryl; R4 is from 1 to 4 groups each independently selected from halogen, alkyl, hydroxy, and alkoxy; and n is an integer of from 2 to 6; and a carbon atom of (CH2)n group can be replaced by oxygen, nitrogen, or sulphur.
- 2. A compound according to claim 1 wherein:R1 is phenyl, naphthyl, pyridinyl, imidazolyl, or tetrazolyl; R2 is hydroxy; R3 is naphthyl; R4 is dichloro, difluoro, dimethoxy, or dimethyl; and n is an integer of from 2 to 6.
- 3. A compound according to claim 1 wherein:R1 is phenyl, naphthyl, pypridinyl, or imidazolyl; R2 is hydroxy; R3 is naphthyl; R4 is 3,4-dichloro; and n is the integer 2 to 4.
- 4. A compound according to claim 1 wherein:R1 is phenyl; R2 is hydroxy; R3 is naphthyl; R4 is 3,4-dichloro; and n is 3.
- 5. A compound according to claim 1 selected from:(R)-{3-(3,4-Dichlorophenyl)-3-[3-(4-hydroxy-4-phenyl-piperidin-1-yl)-propyl]-piperidin-1-yl}-naphthalene-2-yl-phenyl-methanone.
- 6. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of U.S. Ser. No. 09/467,431 filed Dec. 20, 1999, now abandoned, which is a divisional of U.S. Ser. No. 08/983,584 filed Jan. 22, 1998, now U.S. Pat. No 6,040,316 issued Mar. 21, 2000, which is a 371 filing of PCT/US97/15443 filed Sep. 2, 1997, priority based on Provisional Application No. 60/026,385 filed Sep. 16, 1996.
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|
60/026385 |
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US |
Continuations (1)
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Number |
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09/467431 |
Dec 1999 |
US |
Child |
09/873889 |
|
US |