Claims
- 1. A compound of the formula ##STR7## wherein R.sub.1 is unsubstituted, mono-substituted or di-substituted thiomorpholino, where the substitutents are selected from the group consisting of methyl, hydroxymethyl, hydroxyl, phenyl and benzyl;
- R.sub.2 is hydrogen, methyl or benzyl; and
- R.sub.3 is hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1,
- where
- R.sub.1 is thiomorpholino or dimethyl-thiomorpholino;
- R.sub.2 is hydrogen, methyl or benzyl; and
- R.sub.3 is hydrogen, fluorine, chlorine, methyl or methoxy.
- 3. A compound of claim 1,
- where
- R.sub.1 is thiomorpholino;
- R.sub.2 is hydrogen; and
- R.sub.3 is hydrogen, fluorine, chlorine, methyl or methoxy.
- 4. A compound of claim 3, which is 3-amino-4-phenyl-6-thiomorpholino-1H-pyrazolo[3,4-b]pyridine or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 5. An antithrombotic pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective antithrombotic amount of a compound of claim 1.
- 6. The method of preventing or relieving thrombosis in a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective antithrombotic amount of a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2643753 |
Sep 1976 |
DEX |
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Parent Case Info
This is a continuation-in-part of copending application Ser. No. 834,114, filed Sept. 19, 1977, now U.S. Pat. No. 4,182,887 granted Jan. 8, 1980.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3872133 |
Fleckenstein et al. |
Mar 1975 |
|
4048184 |
Hoehn |
Sep 1977 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
834114 |
Sep 1977 |
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