Claims
- 1. A 1-R.sub.1 -3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinone having the formula ##STR5## or acid-addition salt thereof, where R.sub.1 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R is lower-alkyl, and, R' and R" are each hydrogen, amino or hydroxy at least one of R' or R" being other than hydrogen.
- 2. A compound according to claim 1 where R.sub.1 is hydrogen, R is methyl or ethyl, R' is hydrogen, hydroxy or amino and R" is hydroxy or hydrogen the latter only when R' is other than hydrogen.
- 3. 3-Amino-5-(4-hydroxyphenyl)-6-methyl-2(1H)-pyridinone or pharmaceutically acceptable acid-addition salt thereof.
- 4. 3-Amino-5-(3,4-dihydroxyphenyl)-6-methyl-2(1H)-pyridinone or pharmaceutically acceptable acid-addition salt thereof.
- 5. A cardiac composition for increasing cardiac contractility, said composition comprising a pharmaceutically acceptable carrier and, as the active component thereof, a cardiotonically effective amount of 1-R.sub.1 -3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinone or pharmaceutically acceptable acid-addition salt thereof, where R.sub.1 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R is lower-alkyl, and R' and R" are each hydrogen, amino or hydroxy at least one of R' and R" being other than hydrogen.
- 6. A composition according to claim 5 where R.sub.1 is hydrogen, R is methyl or ethyl, R' is hydrogen, hydroxy or amino and R" is hydroxy or hydrogen, the latter only when R' is other than hydrogen.
- 7. A composition according to claim 6 where the active component is 3-amino-5-(4-hydroxyphenyl)-6-methyl-2(1H)-pyridinone or pharmaceutically acceptable, acid-addition salt thereof.
- 8. The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a composition comprising a pharmaceutically acceptable carrier and, as active component thereof, a cardiotonically effective amount of 1-R.sub.1 -3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinone or pharmaceutically-acceptable salt thereof, where R.sub.1 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R is hydrogen or lower-alkyl, R' and R" are each hydrogen, amino or hydroxy at least one of R' and R" being other than hydrogen.
- 9. The method according to claim 8 where R.sub.1 is hydrogen, R is methyl or ethyl, R' is hydrogen, hydroxy or amino and R" is hydroxy or hydrogen the latter only when R' is other that hydrogen.
- 10. The method according to claim 9 where the active component is 3-amino-5-(4-hydroxyphenyl)-6-methyl-2(1H)-pyridinone or pharmaceutically acceptable, acid-addition salt thereof.
- 11. A 1-R.sub.1 -3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinone having the formula ##STR6## or acid-addition salt thereof, where R.sub.1 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R is lower-alkyl, and, R' and R" are each hydrogen or methoxy at least one of R' or R" being methoxy.
- 12. A compound according to claim 11 where R.sub.1 is hydrogen, R is methyl or ethyl, R' is hydrogen or methoxy and R" is methoxy or hydrogen, the latter only when R' is methoxy.
- 13. 3-Amino-5-(4-methoxyphenyl)-6-methyl-2(1H)-pyridinone or acid-addition salt thereof.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of copending applications Ser. No. 300,294, filed Sept. 8, 1981 and now abandoned, and Ser. No. 348,450, filed Feb. 12, 1982 now abandoned, which is a continuation-in-part of Ser. No. 248,840, filed Mar. 30, 1981 and now abandoned.
US Referenced Citations (12)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2070606 |
Sep 1981 |
GBX |
Continuation in Parts (3)
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Number |
Date |
Country |
Parent |
300294 |
Sep 1981 |
|
Parent |
348450 |
Feb 1982 |
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Parent |
248840 |
Mar 1981 |
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