Claims
- 1. 3-Amino or amido-2-(1H-indol-3-yl)propanoic acid compounds characterized by the formula: ##STR21## wherein: R is H, CH.sub.3 or CH.sub.2 CH.sub.3,
- R' is H or ##STR22## X is H, F or OCH.sub.3, Y is H or Cl, and
- Z is H or ##STR23## provided that: (i) when X is F; Y, Z and R' are H and R is H or CH.sub.3 ;
- (ii) when X is H, Y is Cl, Z is H, R is CH.sub.3 and R' is H; and
- (iii) when X is OCH.sub.3 ; Y is H provided further that when Z and R' are H, R is CH.sub.3 ; when Z is H and R' is ##STR24## R is H and when Z is ##STR25## R' is ##STR26## and R is CH.sub.2 CH.sub.3.
- 2. The compounds defined by claim 1 in the form of their pharmaceutically acceptable, non-toxic, acid addition salts.
- 3. A compound as defined by claim 1 wherein X is OCH.sub.3, Y is H, Z is ##STR27## R is CH.sub.2 CH.sub.3 and R' is ##STR28##
- 4. A compound as defined by claim 1 wherein X is OCH.sub.3, Y is H, Z is H, R is CH.sub.3 and R' is H.
- 5. The hydrochloric acid addition salt of the compound defined by claim 4.
- 6. A compound as defined by claim 1 wherein X is OCH.sub.3, Y is H, Z is H, R is H and R' is ##STR29##
- 7. A compound as defined by claim 1 wherein X is H, Y is Cl, Z is H, R is CH.sub.3 and R' is H.
- 8. The hydrochloric acid addition salt of the compound defined by claim 7.
- 9. A compound as defined by claim 1 wherein X is F, Y is H, Z is H, R is H and R' is H.
- 10. A compound as defined by claim 1 wherein X is F, Y is H, Z is H, R is CH.sub.3 and R' is H.
- 11. The hydrochloric acid addition salt of the compound defined by claim 10.
- 12. Methyl 3-amino-2-(5-methoxy-1H-indol-3-yl) propanoate hydrochloride.
- 13. A method of treating hypertension in an individual requiring such treatment which method comprises administering to such individual an anti-hypertensive amount of a compound of the formula: ##STR30## wherein: R is H, CH.sub.3 or CH.sub.2 CH.sub.3,
- R' is H or ##STR31## X is H, F or OCH.sub.3, Y is H or Cl, and
- Z is H or ##STR32## provided that: (i) when X is F; Y, Z and R' are H and R is H or CH.sub.3 ;
- (ii) when X is H, Y is Cl, Z is H, R is CH.sub.3 and R' is H; and
- (iii) when X is OCH.sub.3 ; Y is H provided further that when Z and R' are H, R is CH.sub.3, when Z is H and R' is ##STR33## R is H and when Z is ##STR34## R' is ##STR35## and R is CH.sub.2 CH.sub.3.
- 14. The method of claim 13 wherein the compound administered is in the form of its pharmaceutically acceptable, non-toxic, acid addition salt.
- 15. The method of claim 13 wherein the compound administered is further defined in that X is OCH.sub.3, Y is H, Z is ##STR36## R is CH.sub.2 CH.sub.3 and R' is ##STR37##
- 16. The method of claim 13 wherein the compound administered is further defined in that X is OCH.sub.3, Y is H, Z is H, R is CH.sub.3 and R' is H.
- 17. The method of claim 16 wherein the compound defined therein is administered in the form of its hydrochloric acid addition salt.
- 18. The method of claim 13 wherein the compound administered is further defined in that X is OCH.sub.3, Y is H, Z is H, R is H and R' is ##STR38##
- 19. The method of claim 13 wherein the compound administered is further defined in that X is H, Y is Cl, Z is H, R is CH.sub.3 and R' is H.
- 20. The method of claim 19 wherein the compound defined therein is administered in the form of its hydrochloric acid addition salt.
- 21. The method of claim 13 wherein the compound administered is further defined in that X is F, Y is H, Z is H, R is H and R' is H.
- 22. The method of claim 13 wherein the compound administered is further defined in that X is F, Y is H, Z is H, R is CH.sub.3 and R' is H.
- 23. The method of claim 22 wherein the compound defined therein is administered in the form of its hydrochloric acid addition salt.
BACKGROUND AND PRIOR ART
This application is a continuation-in-part of co-pending application Ser. No. 915,735, filed June 15, 1978, now abandoned.
Non-Patent Literature Citations (1)
Entry |
Rozhkov et al., Zh Org. Khim., 12 [5], p. 1076, (1976). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
915735 |
Jun 1978 |
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