Claims
- 1. A method of making a compound of formula (Ia)
- 2. The method of claim 1, wherein the method further comprises formation of the compound of the formula (IIa) by reacting a compound having the formula R4OH, water, or R4NH2 and a compound of the formula (IIIa)
- 3. The method of claim 2, wherein the method further comprises formation of the compound of the formula (IIIa) by heating a compound having the formula (IVa)
- 4. The method of claim 3, wherein the method further comprises formation of the compound of the formula (IVa) by oxidizing a compound having the formula (Va)
- 5. The method of claim 4, wherein the method further comprises formation of the compound of the formula (Va) by reacting a compound having the formula WCO2R4 and a compound having the formula (Via)
- 6. The method of claim 4, wherein the oxidizing conditions are an electrochemical oxidation.
- 7. A method of making a compound having the formula (Ib)
- 8. The method of claim 7, wherein the method further comprises formation of the compound of the formula (IIb) by reacting a compound having the formula (IIIb)
- 9. The method of claim 8, wherein the method further comprises formation of the compound of the formula (IIIb) by hydrogenating a compound having the formula (IVb)
- 10. The method of claim 9, wherein the method further comprises formation of the compound of the formula (IVb) by reacting a compound having the formula (Vb)
- 11. The method of claim 1, wherein the compound of formula (Ia) has the relative stereochemistry of formula (Ia-1)
- 12. The method of claim 7, wherein the compound of formula (Ib) has the relative stereochemistry of formula (Ib-1)
- 13. The method of claim 1, wherein the reducing agent is a borohydride.
- 14. The method of claim 7, wherein the reducing agent is lithium aluminum hydride.
- 15. The method of claim 9, wherein the catalyst is Rh/alumina or Rh/C.
RELATED APPLICATION
[0001] The present application claims priority to U.S. Patent Application Serial No. 60/428,324, filed Nov. 21, 2002, which is incorporated herein in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60428324 |
Nov 2002 |
US |