Claims
- 1. A compound of general formula (I): ##STR42## in which: z represents oxygen,
- R.sub.1 represents (C.sub.1 -C.sub.6) alkyl,
- R.sub.2 represents hydrogen or (C.sub.1 -C.sub.6) alkyl,
- n is an integer of 1 to 6, inclusive,
- R.sub.3 represents an amino group substituted with:
- a (C.sub.1 -C.sub.6) acyl group which is substituted with phenyl which is optionally substituted with alkyl, alkoxy, hydroxyl, or halogen, its enantiomers, diastereoisomers and epimers as well as its addition salts with a pharmaceutically-acceptable acid.
- 2. A compound of claim 1, wherein R.sub.1 is a methyl group.
- 3. A compound of claim 1, wherein R.sub.2 is an n-propyl group.
- 4. A compound of claim 1, wherein R.sub.1 is at the 5-position.
- 5. A compound of claim 1, which is 5-methoxy 3-{N- 4-(2'-methoxy benzamido)butyl!N-propyl}aminochroman, or an addition salt thereof with a pharmaceutically-acceptable acid.
- 6. A compound of claim 1, which is 5-methoxy 3-{N- 4-(4'-iodo benzamido)butyl!N-propyl)aminochroman, or an addition salt thereof with a pharmaceutically-acceptable acid.
- 7. A compound of claim 1, which is 5-methoxy 3-{N- 4-(4'-fluoro benzamido)butyl!N-propyl}aminochroman, or an addition salt thereof with a pharmaceutically-acceptable acid.
- 8. A pharmaceutical composition comprising as active principle a compound of claim 1, which is useful in the treatment of disorders of the serotoninergic system including depression, stress, psychoses, anxiety, pain, schizophrenia, hypertension, and as an agent modifying feeding and sexual behavior, together with a pharmaceutically-acceptable diluent.
- 9. A method for treating a living animal afflicted with a disorder of the serotoninergic system comprising the step of administering to the said living animal an amount of a compound of claim 1 which is effective for the alleviation of said disorder.
Priority Claims (1)
Number |
Date |
Country |
Kind |
90 04481 |
Apr 1990 |
FRX |
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Parent Case Info
The present application is a continuation-in-part of our prior-filed application Ser. No. 08/033,156, filed Mar. 16, 1993, now U.S. Pat. No. 5,346,916, which in turn is a division of Ser. No. 07/959,044, filed Oct. 9., 1992, now U.S. Pat. No. 5,314,907, issued May 24, 1994, which in turn is a division of Ser. No. 07/677,136, filed Mar. 29, 1991, now U.S. Pat. No. 5,252,578, issued Oct. 12, 1993.
Non-Patent Literature Citations (1)
Entry |
CA 103:22555, (Vinot) ". . . 1-benzopyrano-1,2,4-triazines", J. Hetero. Chem. 1985, 22(1), 33-7. |
Divisions (2)
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Number |
Date |
Country |
Parent |
959044 |
Oct 1992 |
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Parent |
677136 |
Mar 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
33156 |
Mar 1993 |
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