Claims
- 1. A compound selected from the formula (I): ##STR39## in which: Z represents oxygen or sulfur,
- R.sub.1 represents hydrogen or (C.sub.1 -C.sub.6) alkyl,
- R.sub.2 represents hydrogen or (C.sub.1 -C.sub.6) alkyl,
- n is an integer of 1 to 6, inclusive
- R.sub.3 represents the following: in which: and its enantiomers, diastereoisomers and epimers and its pharmaceutically-acceptable acid addition salts.
- 2. A compound as claimed in claim 1, wherein R.sub.1 is a methyl group.
- 3. A compound as claimed in claim 1, wherein R.sub.2 is an n-propyl group.
- 4. A compound as claimed in claim 1, wherein R.sub.1 O in the 5-position.
- 5. A compound as claimed in claim 1, wherein R.sub.2 is a hydrogen atom.
- 6. A compound as claimed in claim 1, selected from 3-{4-[N-propyl-N-(5-methoxy-3-chromanyl)amino]butyl}-2,4-dioxo-3-azabicyclo[3.3.0]octane, its isomers and its addition salts with a pharmaceutically-acceptable acid.
- 7. A compound as claimed in claim 1, selected from (+)-3-{4-[N-propyl-N-(5-methoxy-3-chromanyl)amino]butyl}-2,4-dioxo-3-azabicyclo[3.3.0]octane, and its addition salts with a pharmaceutically-acceptable acid.
- 8. A compound as claimed in claim 1, selected from (-)-3-{4-[N-propyl-N-(5-methoxy-3-chromanyl)amino]butyl}-2,4-dioxo-3-azabicyclo[3.3.0]octane, and its addition salts with a pharmaceutically-acceptable acid.
- 9. A pharmaceutical composition comprising an active principle as claimed in claim 1, which is useful in the treatment of disorders of the serotoninergic system selected from depression, stress, psychoses, anxiety, pain schizophrenia and hypertension, the treatment of atheroma and as an agent modifying feeding and sexual behavior together with a pharmaceutically-acceptable diluent.
- 10. A method for treating a living animal afflicted with a disorder of the serotoninergic system selected from depression, stress, psychoses, anxiety, pain, schizophrenia, hypertension, and atheroma, or requiring modification of feeding or sexual behavior, comprising the step of administering to the said living animal an amount of a compound of claim 1 which is effective for the alleviation of said condition.
Priority Claims (1)
Number |
Date |
Country |
Kind |
90 04481 |
Apr 1990 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed copending U.S. application Ser. No. 07/677,136, filed Mar. 29, 1991, now issued.
US Referenced Citations (7)
Foreign Referenced Citations (2)
Number |
Date |
Country |
222996 |
Nov 1978 |
EPX |
279150 |
Mar 1979 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
677136 |
Mar 1991 |
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