Claims
- 1. A compound of the formula ##STR7## wherein Ar is phenyl or naphthyl; R1 is C.sub.1--6 lower alkyl;
- R2 is hydrogen or C.sub.1--6 alkoxy, hydroxy, halogeno or trifluoromethyl and n is zero, 1 or 2, or R.sub.n --(Ar)-- is methylenedioxyphenyl; and
- m is zero, 1 or 2;
- or a pharmaceutically acceptable salt thereof.
- 2. A compound of claim 1 wherein Ar is phenyl.
- 3. A compound of claim 2 wherein m is zero.
- 4. A compound of claim 3 which is 4-methyl-3-phenyl-5-ethylsulfinyl-4H-1,2,4triazole.
- 5. A compound of claim 1 wherein n is zero or one, m is zero, R is halogeno, and R.sub.1 and R.sub.2 are independently methyl or ethyl.
- 6. A compound of the formula ##STR8## wherein Ar is phenyl or naphthyl;
- R.sub.1 is C.sub.1--6 lower alkyl;
- R.sub.2 is hydrogen or C.sub.1--6 lower alkyl;
- R is C.sub.1--6 lower alkyl, C.sub.1--6 alkoxy, hydroxy, halogeno, or trifluoromethyl, and n is zero, 1 or 2, or R.sub.n --(Ar)-- is methyenedioxyphenyl; and
- m is zero, 1 or 2; or a pharmaceutically acceptable salt thereof;
- with the provisos that (1) R.sub.n --(Ar)--(CH.sub.2).sub.m is other than 2-ethoxyphenyl); (2) when R.sub.n --Ar--(CH.sub.2).sub.m represents phenyl and R.sub.1 represents methyl, R.sub.2 is C.sub.1--6 lower alkyl; and (3) when R.sub.n --(Ar)--CH.sub.2).sub.m represents 4-chlorophenyl, R.sub.2 is other than ethyl.
- 7. A compound of claim 6 wherein Ar is phenyl.
- 8. A compound of claim 7 wherein m is zero.
- 9. A compound of claim 8 which is 4-methyl-3-phenyl-5-methylsulfonyl-4H-1,2,4-triazole.
- 10. A compound of claim 8 which is 4-methyl-3-phenyl-5-ethylsulfonyl-4H-1,2,4-triazole.
- 11. A compound of claim 6 wherein n is zero or one, m is one, R is halogeno and R.sub.1 and R.sub.2 are independently methyl or ethyl.
- 12. A compound of claim 11 which is 3-(2-fluorophenyl)-4-methyl-5-methylsulfonyl-4H-1,2,4-triazole.
Parent Case Info
This is a division of application Ser No. 07/770,837, filed Oct. 4, 1991, now U.S. Pat. No. 5,143,933, which is a continuation-in-part of copending application Ser. No. 07,630,659, filed Dec. 20, 1990, now abandoned, which is a continuation-in-part of application Ser. No. 07/463,082, filed Jan. 10, 1990, now U.S. Pat. No. 4,981,863, which is a division of application Ser. No. 07/126,191, filed Dec. 4, 1987, now U.S. Pat. No. 4,900,743, which is a continuation-in-part of application Ser. No. 07/007,063, filed Jan. 27, 1987, now abandoned.
Non-Patent Literature Citations (4)
Entry |
Journal of Medicinal Chemistry, vol. 14(3), pp. 260-262 (1971), Mhasalkar, M. Y., et al. |
Boll. Chim. Farm., 108 (1969), pp. 128-139, Russo, F., et al. |
Deliwala et al, "Further Studies in substituted, etc" CA 74:111968u (1971). |
Russo et al, "1,2,4-Triazole Derivatives" CA71:49853k (1969). |
Divisions (2)
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Number |
Date |
Country |
Parent |
770837 |
Oct 1991 |
|
Parent |
126191 |
Dec 1987 |
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Continuation in Parts (3)
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Number |
Date |
Country |
Parent |
630659 |
Dec 1990 |
|
Parent |
463082 |
Jan 1990 |
|
Parent |
7063 |
Jan 1987 |
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