Claims
- 1. A compound of the formula ##STR82## wherein: R.sup.1 is C.sub.5 -C.sub.7 cycloalkyl; ##STR83## each of R.sup.2 and R.sup.3 independently is hydrogen or methyl; each R.sup.4 independently is halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy or trifluoromethyl;
- each R.sup.5 independently is halo, C.sub.1 -C.sub.4 alkyl or trifluoromethyl;
- m is 0, 1 or 2;
- n is 0 or 1; and
- the pharmaceutically acceptable acid addition salts thereof.
- 2. A compound of claim 1 wherein Ar is ##STR84##
- 3. A compound of claim 1 wherein Ar is ##STR85##
- 4. A method for inhibiting norepinephrine uptake in mammals which comprises adminstering to a mammal requiring increased neurotransmission of norepinephrine a pharmaceutically effective amount of a compound of claim 1.
- 5. A method of treating depression in humans comprising adminstering to a human suffering from depression an effective antidepressant dose of a compound of claim 1.
- 6. A method of treating anxiety in human comprising adminstering to a human suffering from anxiety an effective antianxiety dose of a compound of claim 1.
- 7. A method of treating obesity in humans comprising adminstering to a human suffering from obesity an effective antiobesity dose of a compound of claim 1.
- 8. A method of suppressing the desire of humans to smoke comprising adminstering to a human in need of such suppression an effective dose to relieve the desire to smoke of a compound of claim 1.
- 9. A method of suppressing the desire of humans to consume alcohol comprising adminstering to a human in need of such suppression an effective dose to relieve the desire to consume alcohol of a compound of claim 1.
- 10. A pharmaceutical formulation comprising a compound of claim 1 and a pharmaceutically acceptable carrier, diluent or excipient therefor.
Parent Case Info
This application is a continuation of application Ser. No. 945,122, filed on Dec. 22, 1986 now abandoned.
US Referenced Citations (12)
Foreign Referenced Citations (4)
Number |
Date |
Country |
2482956 |
May 1980 |
FRX |
662591 |
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GBX |
1343527 |
Jan 1974 |
GBX |
2060618 |
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GBX |
Non-Patent Literature Citations (1)
Entry |
Yoshida et al., "Yakugaku Zasshi", vol. 93, No. 4, pp. 419-528 (1973). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
945122 |
Dec 1986 |
|