Claims
- 1. A compound according to formula I, or a pharmaceutically acceptable salt thereof:
- 2. A compound according to claim 1 wherein Ra is a
- 3. A compound according to claim 2 wherein
- 4. A compound according to claim 2 wherein X is H, F or C≡N.
- 5. A compound according to any of claim 2, wherein R3 is H, OH, Cl, methyl, ethyl, isopropyl, OMe, OEt, O-iPr, O-allyl or O-n-Pr.
- 6. A compound according to claim 1, wherein
- 7. A compound according to claim 2, wherein n is 1, 2 or 3.
- 8. A compound according to claim 2 R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are each H.
- 9. A compound according to claim 1 wherein Q forms a phenyl-fused heterocyclic group with the adjacent phenyl group, wherein said Q group and said phenyl group form a group according to the chemical structure:
- 10. A compound according to claim 1 selected from
3-(3-Cyclopropylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenol; 3-(3-Ethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(3-Cyclopropylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(3-Cyclohexyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenol; 3-[8-Methoxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(8-Methoxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[8-Methoxy-3-(1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(3-Hexyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(2-Ethyl-butyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 2-[8-(3-Hydroxy-phenyl)-3-aza-bicyclo[3.2.1]oct-3-ylmethyl]-indan-2-ol; 3-[8-Methoxy-3-(1-methyl-1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(8-Methoxy-3-thiophen-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(8-Methoxy-3-thiazol-2-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol; N-[3-(3-Cyclopropylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-(8-Methoxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(2-Hydroxy-indan-2-ylmethyl)-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol; N-[3-(3-Isobutyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-(8-Methoxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-[3.2.1]oct-8-yl}-phenol; 3-[8-Methoxy-3-(3-phenyl-prop-2-ynyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[8-Methoxy-3-(3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 2-[8-(3-Hydroxy-phenyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-3-ylmethyl]-indan-2-ol; N-{3-[8-Methoxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(8-Methoxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-[3-(1H-Indol-3-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(3-Benzofuran-2-ylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(2-Ethyl-butyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(3-Hexyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-(8-Methoxy-3-naphthalen-2-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl}7-benzamide; 3-(8-Methoxy-3-quinolin-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; N-[3-(8-Methoxy-3-pyridin-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-[3-(4-Chloro-2-fluoro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[8-Methoxy-3-(1-methyl-1H-indol-3-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-indan-2-yl methyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-[3-(8-Methoxy-3-thiazol-2-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-[8-Methoxy-3-(2-phenethyloxy-ethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-[3-(3-Heptyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-[3-(8-Methoxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-[3-(4-Hydroxy-naphthalen-1-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(4-Fluoro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 3-[8-Methoxy-3-(4-pyrrolidin-1-yl-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[8-Methoxy-3-(3-methyl-benzo[b]thiophen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(1-Hydroxy-3-phenyl-cyclobutylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(2-Ethyl-hexyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(8-Methoxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(3-hexyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 3-(3-Biphenyl-4-ylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; N-{3-[3-(2-Hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[8-Methoxy-3-(4-methoxy-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-pyrid in-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 3-[8-Methoxy-3-(3-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(4-Chloro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-thiophen-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid [3-(3-cyclohexylmethyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-(3-{8-Hydroxy-3-[3-(1-hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-methanesulfonamide; 3-[3-(9H-Fluoren-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(1H-Indol-3-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(3-Benzofuran-2-ylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 3-[8-Methoxy-3-(3-phenoxy-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[8-Hydroxy-3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 3-[3-(4-Dimethylamino-naphthalen-1-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-[3-(8-Methoxy-3-naphthalen-1-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-[3-(8-Methoxy-3-naphthalen-2-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-(3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-methanesulfonamide; N-[3-(8-Methoxy-3-quinolin-4-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-[3-(8-Methoxy-3-quinolin-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[3-(4-Chloro-2-fluoro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-{3-[8-Methoxy-3-(1-methyl-1H-indol-3-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-phenyl-prop-2-ynyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[8-Hydroxy-3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(2-Hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(4-chloro-benzyl)-8-hydroxy-3-aza-35 bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[3-(4-Hydroxy-naphthalen-1-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(1H-indol-3-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[8-Methoxy-3-(4-pyrrolidin-1-yl-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[8-Methoxy-3-(3-methyl-benzo[b]thiophen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(3-benzofuran-2-ylmethyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-{3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2,2,2-Trifluoro-N-{3-[3-(2-hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-acetamide; N-[3-(3-Biphenyl-4-ylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-naphthalen-2-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-naphthalen-1-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid (3-{8-hydroxy-3-[3-(1-hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-amide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-quinolin-4-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-quinolin-3-ylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(1-methyl-1H-indol-3-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[8-Methoxy-3-(3-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid{3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[3-(9H-Fluoren-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(2-phenethyloxy-ethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[8-Methoxy-3-(3-phenoxy-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(4-Dimethylamino-naphthalen-1-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(4-hydroxy-naphthalen-1-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(4-pyrrolidin-1-yl-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-methyl-benzo[b]thiophen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid [3-(3-biphenyl-4-ylmethyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(9H-fluoren-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-phenoxy-benzyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; and 2-Methoxy-ethanesulfonic acid {3-[3-(4-dimethylamino-naphthalen-1-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 3-(3-Cyclopropylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenol; 3-(3-Ethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(3-Cyclopropylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(3-Cyclohexyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenol; 3-[8-Methoxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(8-Methoxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(3-Hexyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(2-Ethyl-butyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 2-[8-(3-Hydroxy-phenyl)-3-aza-bicyclo[3.2.1]oct-3-ylmethyl]-indan-2-ol; 3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol; N-[3-(3-Cyclopropylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-(2-Hydroxy-indan-2-ylmethyl)-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol; N-[3-(3-Isobutyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-(8-Methoxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[8-Methoxy-3-(3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[8-Methoxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(8-Methoxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(2-Ethyl-butyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(3-Hexyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl}-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[8-Methoxy-3-(2-phenethyloxy-ethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-[3-(3-Heptyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-methyl-butyl)-3-aza-25bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-[3-(8-Methoxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[3-(4-Fluoro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(1-Hydroxy-3-phenyl-cyclobutylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; N-{3-[3-(2-Ethyl-hexyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(8-Methoxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(3-hexyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-{3-[3-(2-Hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(4-Chloro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(3-cyclohexylmethyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-(3-{8-Hydroxy-3-[3-(1-hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-methanesulfonamide; N-{3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[8-Hydroxy-3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; N-(3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-methanesulfonamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-20 phenyl]-amide; N-{3-[8-Hydroxy-3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(2-Hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-{3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 2,2,2-Trifluoro-N-{3-[3-(2-hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-acetamide; 2-Methoxy-ethanesulfonic acid (3-{8-hydroxy-3-[3-(1-hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-amide; 2-Methoxy-ethanesulfonic acid{3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(2-phenethyloxy-ethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 3-(3-Ethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(3-Cyclopropylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[8-Methoxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(8-Methoxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-(3-Hexyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[3-(2-Ethyl-butyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-(8-Methoxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-benzamide; 3-[8-Methoxy-3-(3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl}-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[8-Methoxy-3-(2-phenethyloxy-ethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 3-[3-(1-Hydroxy-3-phenyl-cyclobutylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-benzamide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid [3-(3-hexyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid [3-(3-cyclohexylmethyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid [3-(8-hydroxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(3-phenyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid (3-{8-hydroxy-3-[3-(1-hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-amide; 2-Methoxy-ethanesulfonic acid{3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[8-hydroxy-3-(2-phenethyloxy-ethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; 2-Methoxy-ethanesulfonic acid {3-[3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-amide; N-[3-(3-Cyclopropylmethyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-[3-(3-Isobutyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[8-Methoxy-3-(3-methyl-butyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(8-Methoxy-3-pentyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[3-(2-Ethyl-butyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(3-Hexyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-[3-(3-Heptyl-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-[3-(8-Methoxy-3-phenethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[3-(4-Fluoro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(2-Ethyl-hexyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-[3-(8-Methoxy-3-octyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenyl]-methanesulfonamide; N-{3-[3-(2-Hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(4-Chloro-benzyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-(3-{8-Hydroxy-3-[3-(1-hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-methanesulfonamide; N-{3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[8-Hydroxy-3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-(3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl}-phenyl)-methanesulfonamide; N-{3-[8-Hydroxy-3-(2-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(2-Hydroxy-indan-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; N-{3-[3-(2-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-8-methoxy-3-aza-bicyclo[3.2.1]oct-8-yl]-phenyl}-methanesulfonamide; 3-(3-Cyclopropylmethyl-3-aza-bicyclo[3.2.1]oct-8-yl)-phenol; 3-(3-Cyclopropylmethyl-8-hydroxy-3-aza-bicyclo[3.2.1]oct-8-yl)-phenol; 3-{3-[3-(1-Hydroxy-cyclohexyl)-propyl]-3-aza-bicyclo[3.2.1]oct-8-yl}-phenol; 3-[3-(1-Hydroxy-cyclohexyl)-propyl]-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol; 3-[3-(3-Cyclohexyl-propyl)-3-aza-bicyclo[3.2.1]oct-8-yl]-phenol; 3-(3-Cyclohexyl-propyl)-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol; 2-[8-(3-Hydroxy-phenyl)-3-aza-bicyclo[3.2.1]oct-3-ylmethyl]-indan-2-ol; and 3-(2-Hydroxy-indan-2-ylmethyl)-8-(3-hydroxy-phenyl)-3-aza-bicyclo[3.2.1]octan-8-ol;
and pharmaceutically acceptable salts thereof.
- 11. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 in combination with a pharmaceutically acceptable carrier, excipient or additive.
- 12. A method of treating in a mammal, in need thereof, a disease state, disorder or condition selected from the group consisting of irritable bowel syndrome, constipation, nausea, vomiting, pruritic dermatoses, psoriasis; eczema; an insect bite; eating disorders, depression, anxiety, schizophrenia; drug addiction, an opioid overdose, sexual dysfunction, stroke, head trauma, traumatic brain injury, spinal damage, Parkinson's disease, Alzheimer's disease, age-related cognitive decline and Attention Deficit and Hyperactivity Disorder, said method comprising administering to said mammal an amount of a compound according to claim 1 effective in treating said disease state, disorder or condition.
- 13. A method of synthesizing a compound of the formula:
- 14. A method of synthesizing a compound of the formula IV:
- 15. A method of synthesizing a compound according to chemical structure IVa:
Parent Case Info
[0001] This application claims priority under 35 U.S.C. 119(e) of U.S. Provisional 60/462,629, filed Apr. 14, 2003. The entire contents of the prior application U.S. Provisional 60/462,629 is incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
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60462629 |
Apr 2003 |
US |