Claims
- 1. A compound of Formula (I) represented by the structure:
- 2. The compound of claim 1, wherein X is —NH —, —NR5, or —O— or a pharmaceutically acceptable salt thereof.
- 3. The compound of claim 1, wherein T and Z are carbon or a pharmaceutically acceptable salt thereof.
- 4. The compound of claim 1, wherein T is N and Z is carbon or a pharmaceutically acceptable salt thereof.
- 5. The compound of claim 1, wherein T is carbon and Z is N or a pharmaceutically acceptable salt thereof.
- 6. The compound of claim 1, wherein T and Z are carbon, n is 0 and X is —NH— or a pharmaceutically acceptable salt thereof.
- 7. The compound of claim 1, wherein T is carbon, n is 0 and Z is N and X is —NH— or a pharmaceutically acceptable salt thereof.
- 8. The compound of claim 1, wherein T is N and Z is carbon, n is 0 and X is —NH— or a pharmaceutically acceptable salt thereof.
- 9. The compound of claim 1, wherein T and Z are carbon, n is 0, X is —NH— and R1 is aryl or a pharmaceutically acceptable salt thereof.
- 10. The compound of claim 1, wherein T is carbon, Z is N, X is —NH —, n is O and R1 is aryl or a pharmaceutically acceptable salt thereof.
- 11. The compound of claim 1, wherein T is N, Z is carbon, X is —NH —, n is O and R is aryl or a pharmaceutically acceptable salt thereof.
- 12. The compound of claim 1, wherein:
X is —NH —; n is 0; R1 is a phenyl ring optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR, —Q, —S(O)m R5, —NHSO2 R5, —R6OH, —R6OR, —R6NH2, —R6NHR5, —R10Q, —R6SH, —R6S(O)R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, —NHR7NHR5, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR° C.(O)R , —NHR° C.(O)R5, —C(O)R , —C(O) OR5, —C(O)NHR5, —C(O) Q, —R° C.(O) H, —R° C.(O)R5, —R° C.(O) OH, —R° C.(O) OR5, —R6C(O)NH2, —R° C.(O)NHR5, —R6C(O) Q, —R5OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O) Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH —, —NHC(O)—, —NHSO2—, —So2 NH —, —C(OH) H —, —O(C(R9)2)—, —S (O)m(C(R9)2)—, —NH(C(R9)2)—, —NR10O(C(R9)2)—, —(C(R9)2)—, —(C(R9)2)—O —, (C(R9)2)—S(O) n-, —(C(R9)2)qNH —, (C(R9)2)—NR °—C═C—, cis and trais —CH═CH-and cycloalkyl of 3 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof.
- 13. The compound of claim 1, wherein:
T and Z are carbon; X is —NH —; n is 0; R1 is a phenyl ring optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, NHR5, —Q. —S(O)m R5, —NHSO2 R5, —R6OH, —R6OR5, —R NH2, —R NUR, —R Q, —R SH, —R6S(O)m R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, NHR7NHR5, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5, —C(O)OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHRI, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH —, —NHC(O)—, —NHSO2—, —SO2NH —, —C(OH) H —, —O(C(R9)2)—, —S(O)m(C(R9)2)—, —NH(C(R9)2)—, —NR10(C(R9)2)—, (C(R9)2)—, (C(R9)2)—O, —(C(R9)2)—S(O)m—, —(C(R9)2)qNH —, —(C(R9)2)—NR10O —, —C═C—, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof.
- 14. The compound of claim 1, wherein:
X is —NH —; n is 0; A is absent; R1 is a phenyl ring optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —ORe, NHR5, Q —S(O)mR5, —NHSO2R5, —R6OH, —R6OR5, —R6NH2, —R6NHR5, —R6Q, —R6SH, —R6S(O)m R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, NRNH5,—NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHRs, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5, —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R C(O)NHR5, —R6C(O)Q, —R OC(O)R5, —R OC(O)NH2, —R OC(O)NHR, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH —, —NHC(O)—, —NHSO2—, —SO2 NH —, —C(OH) H —, —O(C(R9)2)—, —S(O)m(C(R9)2)—, —NH(C(R9)2)—, —NR P0 (C(R9)2)—, —(C(R9)2)—, (C(R9)2)—O —, —(C(R9)2)—S(O)m—, —(C(R9)2)—M{, (C(R9)2)—NR10O —, —C═C—, cis and traits —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof.
- 15. The compound of claim 1, wherein
X is —NH—; T and Z are carbon; n is 0; A is absent; R1 is a phenyl ring optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, —Q, —S(O)m R5, —NHSO2 R5, —R6OH, —R6OR 5,—R6 NH2, —R6 NR5, —RQ, —R6SH, —R6S(O)R5, —NHR7OH, —N7OR5, —N(R5)R7OH, —N(R5)R7OR 5, —NHR7 NH2, —NBR7 NR5, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5, —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R 5,—R6C(O) OH, —R6C(O) OR 5,—R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NESO2—, —SO2 NH—, —C(OH) H —, O(C(R9)2)—, —S(O)m(C(R9)2)—, —NH(C(R9)2)—, —NR10 (C(R9)2)—, —(C(R9)2)—, —(C(R9)2)—O —, —(C(R9)2)—S(O) in-i —(C(R9)2)qNH—, —(C(R9)2)—NR10O —, —C═C—, cis and trans —CH —CH-and cycloalkyl of 3 to 10 carbon atoms; or a phaimaceutically acceptable salt thereof.
- 16. The compound of claim 1 wherein:
T and Z are carbon; X is —NH—; n is 0; R1 is a phenyl ning substituted with 1 to 4 substituents which may be the same or different independently selected from H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3 —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, —Q, —S(O)m R5, —NHSO2 R5, —R6OH, —R6OR5, —R6 NH2, —R6NHR, —R6Q, —R6SH, —R6S(O)m R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, —NHR7NHR5, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NMR6C(O)R , —C(O)R5, —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R60C(O)NH2, —R6OC(O)NHR5, —R60C(O)Q and YR8 cgroups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2NH—, —C(OH) H —, —O(C(R9)2)—, —S(O) rn(C(R9) 2), —NH(C(R9)2)—, —NR10 (C(R9)2)—, (C(R9)2)—, —(C(R9)2)—O —, (C(R9)2)—S(O) m (C(R9)2)qNH, —(C(R9)2)—NR10O —, —CC-, cis and trans —CH═CH-and cycloalkyl of 3 to 10 carbon atoms; A is absent; R4 is (C(R9)2)rH , r is 0; or a phaimaceutically acceptable salt thereof.
- 17. The compound of claim 1 wherein:
T and Z are carbon; R2a and R2b are hydrogen; R2c is selected from —H, —J, —CF3, —OCF3, —R , —OR5, —OR11, —OR7OH, —OR7OR and —S(O)m R5; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, Q —S (O)m R5, —NHSO2 R5, —R6OH, —R6OR5, —R6 NH2, —R6NHRI, —R6Q, —R6SH, —R6 (O)m R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, M7 N}R5, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7 N]HR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5, —C(O) OR5, —C(O) NIR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHRI, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, O(C(R9)2)—, —S (O)m(C(R9)2)—, —NH(C(R9)2)—, —NR 0 (C(R9)2)—, —(C(R9)2)—, (C(R9)2)—O, (C(R9)2)—S(O) m-n (C(R9)2)qNH—, (C(R9)2)—NR11, —C═C- cis and trans —CH═CH-and cycloalkyl of 3 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof.
- 18. The compound of claim 1 wherein:
T and Z are carbon; R2a and R2b are hydrogen; R2c is selected from —H, —J, —CF3, —OCF3, —R5, —OR5, —OR10, —OR7OH, —OR7OR and —S(O)m R5; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, —Q, S(O)m R, —NHSO2 R , —R OH —R 0 R5, —R6 NH2, —R NHR5, —R —R SH, —R6S(O)m R5, —NHR7OH, —NHR7OR5, —N(R5)R70H, —N(R5)R7OR5, —NHR7 NH2, —NHR7NHR5, —NHR7Q, —N(R5)R7 NM2, —N(R5)R7NHRs, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —ORC(O)R5—NHR6C(O)R5, —C(O)R , —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, O(C(R9)2)—, —S(O)m(C(R9)2)—, —NH(C(R9)2)—, —NR10O(C(R9)2)—, —(C(R9)2)—- —(C(R9)2)—O —, —(C(R9)2)—S(O)m—, —(C(R9)2)qNH—, —(C(R9)2)—NR10O —, —C═C—, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; A is absent; or a pharmaceutically acceptable salt thereof.
- 19. The compound of claim 1 wherein:
T and Z are carbon; R2a and R2b are hydrogen; R2c is selected from —H, —J, —CF3, —OCF3, —R5, —OR5, -oR11, —OR7OH, —OR7OR5 and —S(O).R5; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, NHR5, —Q. —S(O)m R , —NHSO2 R, —R6OH, —R6OR5, —R6NH2, —R NHR, —R6Q, —R SH —R S(O)m R5, —NHR7OH, —NHR 0 R5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, —NHR7NHR5, —NHR7Q. —N(R)R NH2, —N(R)R7NHR, —N(R)RQ, —OR OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O) N{R5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5 ,—C(O) OR5, —C(O)NHR5, —C(O)Q, —R° C.(O) H, —R C(O)R5, —R C(O) OH, —R6C(O) OR, —R C(O)NH2, —R6C(O)NHR5, —R C(O)Q, —R OC(O)R5, —R OC(O)NH2, —R OC(O)NHR, —R OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, —O(C(R9)2)—, —S(O)m(C(R9)2)—, NH(C(R9)2)—, —NR10 (C(R9)2)—, (C(R9)2)—, (C(R9)2)—O —, —(C(R9)2)—S(O), —(C(R9)2)qNH, —(C(R9)2)—NR10C —C-, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; R4 is —(C(R9)2)2H ; r is 0; A is absent; R3 is attached to carbon-7 of Formula (I) and is selected from aryl, heteroaryl, bicyclic heteroaryl, alkenyl, alkynyl wherein each aryl, heteroaryl, bicyclic heteroaryl, alkenyl, and alkynyl is optionally substituted by one or more of —RIO, —(C (R9)2)—,R2, —CHO, 1,3-dioxolane, —CONH2, —CO2 R10, —CONHR10, —COR10, —(C(R9)2)qOH, (C(R9)2)—OR10, —(C(R9)2)qNHR10, —(C(R9)2)qNH2, G(C(R9)2)—,OR10, G(C(R9)2)pOH, and G(C(R9)2)—pR 2; or a pharmaceutically acceptable salt thereof.
- 20. The compound of claiml wherein:
T and Z are carbon; R2a and R2b are hydrogen; R2c is selected from —H, —J, —CF3, —OCF3, —R5, —OR5, —OR11, —OR7OH, —OR7OR and —S(O)mR5; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —Rs, —OR5, —NHR5, —Q, —S(O)m R, —NHSO2 R5, —R6OH, —R6OR5, —R6NH2, —R6NHR5, —R6Q, —R SH, —R (O) HR5, —NHR7OH, —N(R5)R7OH, —N(R )R —NHR7 NH2, —NHR7NHRs, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R , —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, —O(C(R9)2)—, —S(O).(C(R9)2)—, NH(C(R9)2)—, —NR10(C(R9)2)—, —(C(R9)2)—, —(C(R9)2)—O, (C(R9)2)—S(O)m—, —(C(R9)2)qNH—, (C(R9)2)—NR10C═C—, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; R4 is —(C(R9)2)2H ; r is 0; A is absent; R3 is attached to carbon-6 of Formula (I) and is selected from aryl, heteroaryl, bicyclic heteroaryl, alkenyl, alkynyl wherein each aryl, heteroaryl, bicyclic heteroaryl, alkenyl, alkynyl is optionally substituted by one or more of —R°, —(C(R9)2)—sR12,—CHO, 1,3-dioxolane, —CONH2, —CO2 R11, —CONHR10, —COR10, —(C(R9)2)qOH, —(C(R9)2)—OR11, —(C(R9)2)qNHR10, —(C(R9)2)qNH2, —G(C(R9)2)—pORll, —G(C(R9)2)pOH, and —G(C(R9)2)—pR12; or a pharmaceutically acceptable salt thereof.
- 21. The compound of claim 1, wherein:
T and Z are carbon; R2a and R2b are hydrogen; R2c is attached to carbon-6 or carbon-7 of Formula (I) and is selected from —H, —J, —CF3, —OCF3, —R5, —OR5, —OR11, —OR7OH, —OR7OR and —S(O)m R5; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3,—Rs, —OR5, —NHR5, Q, —S(O)m R5, —NHSO2 R5, —R6OH, —R60 R5, —R6 NH2, —R6NHR5, —R6Q, —R6SH, —R6S(O)m Rl, —NHR7OH, H7OR , —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, —NHR7NHRs, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHRs, —N(Rs)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHRI, —OR6C(O)R5, NHR6C(O)R5, —C(O)R5, —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and —YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, O(C(R9)2)—, —S(O)m(C(R9)2)—, —NH(C(R9)2)—, —NR10(C(R9)2)—, —(C(R9)2)—, —(C(R9)2)—O —, —(C(R9)2)—S(O)m—, (C(R9)2)qNH, —(C(R9)2)—NR10O —, —C=—C-, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; R4 is —(C(R9)2)2H ; r is 0; A is absent; R3 is attached to carbon-6 or carbon-7 of Formula (I) and is selected from aryl, heteroaryl, bicyclic heteroaryl, alkenyl, alkynyl wherein each aryl, heteroaryl, bicyclic heteroaryl, alkenyl, alkynyl is optionally substituted by one or more of —RIO, —(C(R9)2)—SR12, —CHO, and 1, 3-dioxolane; or a pharmaceutically acceptable salt thereof.
- 22. The compound of claim 1, wherein X:
T and Z are carbon; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, —Q, —S(O).R5, —NHSO2 R5, —R6OH, —RO0 R5, —R6 NH2, —R N6 R5, —R6Q, —R6SH, —R (O)m R , —NHR7OH, —NHR7OR5, —N(R)R OH, —N(R5)R7OR5, —NHR7 NH2, NHR7 NHs, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7 NBR5, —N(Rs)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)Rs , —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, —O(C(R9) 2), S(O),(C(R9)2)—, —NH(C(R9)2)——NR10 (C(R9)2)—, —(C(R9)2)—, —(C(R9)2)—O —, (C(R9)2)—S(O) m (C(R9)2)qNH, (C(R9)2)—NRl°—C═C—, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; R2a and R2b are H; R2c is attached to carbon-6 and is selected from —H, —J, —CF3, —OCF3, —R2,—OR5, —OR11, —OR7OH, —OR7OR5 and —S(O),,R5; R3 is attached to carbon-7 of Formula (I) and is selected from heteroaryl, phenyl, alkenyl of 2 to 6 carbon atoms or alkynyl of 2 to 6 carbon atoms with each heteroaryl, phenyl, alkenyl and alkynyl group further substituted by one or more of the group —(C(R9)2)—,R12; A is absent; R4 is (C(R9)2)2H ; r is 0; or a pharmaceutically acceptable salt thereof.
- 23. The compound of claim 1, wherein:
T and Z are carbon; X is —NH—; n is 0; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, —Q, —S(O)m R 5,—NHSO2 R 5,—R6OH, —R6OR5, —R6NH2, —RINHR5, —R6Q, —R6SH, —R6S(O),R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR6NH2, —NHR7NHR5, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5 ,—C(O) OR5, —C(O)NHR5, —C(O)Q, —R C(O) H, —R C(O)R5, —R6C(O) OH, —R C(O) OR , —R C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O) NIR5, —R6OC(O)Q and —YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, O(C(R9)2)—7 S(O)m(C(R9)2)—l —NH(C(R9)2)—, —NR10 (C(R9)2)—, (C(R9)2)—, —(C(R9)2)—O —, —(C(R9)2)—S(O)m—, —(C(R9)2)qNH—, —(C(R9)2)—NR10O —, —C═C—, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; R2a and R2b are H; R2c is attached to carbon-7 of Formula (I) and is selected from —H, —J, —CF3, —OCF3, —R5, —OR5, —OR11)—OR7OH, —OR7OR5 and —S(O)m R5; R3 is attached to carbon-6 of Formula (I) and is selected from heteroaryl, phenyl, alkenyl of 2 to 6 carbon atoms or alkynyl of 2 to 6 carbon atoms with each heteroaryl, phenyl, alkenyl and alkynyl group substituted by one or more of the group —(C(R9)2)sR12; A is absent; R4 is —(C(R9)2)2H ; r is 0; or a pharmaceutically acceptable salt thereof.
- 24. The compound according to claim 1 wherein:
X is —NH—; T and Z are carbon; n is 0; R2a and R2b are H; R2c is attached to carbon-6-or carbon-7 of Formula (I) and is selected from —H, —J, —CF3, —OCF3, —R5, —OR5, —OR10, —OR7OH, —OR7OR5 and —S(O),nR5; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —N}H2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, —NHR5, —Q, —S(O)m R5, —NHSO2 R , —R6OH, —R6OR 5,—R6 NH2, —R6 NIRl, —R6Q, —R6SH, —R S(O)R —NHR7OH, —NHR7OR, —N(R5)R 7OH, —N(R5)R7OR5, —NHR7 NH2, NBR7NHRI, —NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O)NHR5, —OR6C(O)R5, —NHR6C(O)R5, —C(O)R5, —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR5, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and —YR groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, —O(C(R9)2)—, S(O)m(C(R9)2)—, —NH(C(R9)2)—, —NRk°(C(R9)2)—, —(C(R9)2)—, (C(R9)2)—O —, —(C(R9)2)—S(O) i- —(C(R9)2)qNH, —(C(R9)2)—NR11—, —CC-, cis- and trans- —CH═CH-and cycloalkyl of 3 to 10 carbon atoms; R3 is attached to carbon-6 or carbon-7 of Formula (I) and is alkenyl of 2 carbon atoms A is absent; or a pharmaceutically acceptable salt thereof.
- 25. The compound according to claim 1 wherein:
X is —NH—; T and Z are carbon; n is 0; R2a and R2b are H; R2c is attached to carbon-6 or carbon-7 of Formula (I) and is selected from —H, —J, —CF3, —OCF3,—R5, —OR5, —OR11, —OR7OH, —OR7OR5 and —S(O) rnR5; R1 is phenyl optionally substituted with 1 to 4 substituents which may be the same or different independently selected from —H, —J, —NO2, —NH2, —OH, —SH, —CN, —N3, —COOH, —CONH2, —NHC(O)NH2, —C(O) H, —CF3, —OCF3, —R5, —OR5, NRs, Q, —S(O)m R , —NHSo2 R5, —R6OH, —R6OR5, —R6NH2, —R6NHR5, —R6Q, —R6SH, —R6S(O)m R5, —NHR7OH, —NHR7OR5, —N(R5)R7OH, —N(R5)R7OR5, —NHR7 NH2, —NHR7NHR5—NHR7Q, —N(R5)R7 NH2, —N(R5)R7NHR5, —N(R5)R7Q, —OR7OH, —OR7OR5, —OR7 NH2, —OR7NHR5, —OR7Q, —OC(O)R5, —NHC(O)R5, —NHC(O) NBR5, —OR6C(O)R 5,—NUR6C(O)R5, —C(O)R5, —C(O) OR5, —C(O)NHR5, —C(O)Q, —R6C(O) H, —R6C(O)R5, —R6C(O) OH, —R6C(O) OR5, —R6C(O)NH2, —R6C(O)NHR, —R6C(O)Q, —R6OC(O)R5, —R6OC(O)NH2, —R6OC(O)NHR5, —R6OC(O)Q and YR8 groups wherein Y is independently selected from —C(O)—, —C(O) O —, —OC(O)—, —C(O)NH—, —NHC(O)—, —NHSO2—, —SO2 NH—, —C(OH) H —, O(C(R9)2)—, —S(O)m(C(R9)2)—, NH(C(R9)2)—, —NR1 (C(R9)2)—, (C(R9)2)—, (C(R9)2)—O —, (C(R9)2)—S(O)m—, (C(R9)2)qNH, (C(R9)2)—NR5, —C═C—, cis and trans —CH═CH —and cycloalkyl of 3 to 10 carbon atoms; R3 is attached to carbon-6 or carbon-7 of Formula (I) and is alkynyl of 2 carbon atoms; A is absent; or a pharmaceutically acceptable salt thereof.
- 26. The compound according to claim 1, 4-(4-Chloro-2-fluoroanilino)-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 27. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[(E)-2-(4-pyridinyl) ethenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 28. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[(E)-2-(2-pyridinyl) ethenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 29. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[(E)-2-(4-pylidinyl) ethenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 30. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(1,3-dioxolan-2-yl)-2-furyl]-3-quinolinecarbonithile or a pharmaceutically acceptable salt thereof.
- 31. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-(5-formyl-2-furyl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 32. The compound according to claim 1, 7-[5-(4-Morpholinylmethyl)-3-thienyl]-4-(4-phenoxyanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 33. The compound according to claim 1, 4-(4-Benzylanilino)-7-[5-(4-morpholinylmethyl)-3-thienyl ]-3-quinolinecarbonitlile or a pharmaceutically acceptable salt thereof.
- 34. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-{5-[2-(4-morpholinyl) ethyl]-2-thienyl}-3-quinolinecarbonitiile or a pharmaceutically acceptable salt thereof.
- 35. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 36. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[5-(4-25 morpholinyl)-1-pentynyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 37. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[(E/Z)-5-(4-morpholinyl)-1-pentenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 38. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[5-(4-mopholinylmethyl)-2-ftiryl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 39. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-(3-hydroxy-1-propynyl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 40. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[3-(dimethylamino)-1-propynyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 41. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[(E/Z)-6-(4-morpholinyl)-1-hexenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 42.The compound according to claim 1, 7-[4,5-Bis(4-morpholinylmethyl)-2-thienyl]-4-(2,4-dichloroanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 43. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[5-(2-pyridinyl)-2-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 44. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-15-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl}-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 45. The compound according to claim 1, 7-[4,5-Bis(4-morpholinylmethyl)-2-thienyl]-4-(2,4-dichloro-5-methoxyanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 46. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{5-[(E)-3-(4-morpholinyl)-1-propenyl]-2-thienyl}-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 47. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{5-[4-(4-morpholinyl) butyl]-2-thienyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 48. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(4-morpholinylmethyl)-2-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 49. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 50. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-[5-(4-morpholinylmethyl)-3 thienyll]-3-quinolinecarbonitfile or a pharmnaceutically acceptable salt thereof.
- 51. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[3-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 52. The compound according to claim 1, 4-(2,4-Dichloro -5-methoxyanilino)-7-{4-[2-(4-morpholinyl) ethyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 53. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[3-[2-(4-molpholinyl ) ethyl ]phenyl}-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 54. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[4-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 55. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{4-[(4-ethyl- I -piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 56. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl}-6-methoxy-3-quinolinecarbonitlile or a pharmaceutically acceptable salt thereof.
- 57. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{4-[2-(4-ethyl-1-piperazinyl) ethyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 58. The compound according to claim 1, 4-{3-Chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 59. The compound according to claim 1, 7-[3,4-Bis(4-morpholinylmethyl) phenyl]-4-(2,4-dichloro-5-methoxyanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 60. The compound according to claim 1, 7-[3,4-Bis(4-morpholinylmethyl) phenyl]-4- {3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 61. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitlile or a pharmaceutically acceptable salt thereof.
- 62. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[4-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 63. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-{3-[2-(4-morpholinyl) ethyl]phenyl }-3-quinolinecarbonitiile or a pharmaceutically acceptable salt thereof.
- 64. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-morpholinylmethyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 65. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(4-[2-(4-morpholinyl) ethyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 66. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 67. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(1,3-dioxolan-2-yl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 68. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-(5-foimyl-3-thienyl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 69. The compound according to claim 1, 4-(2,4-Dichloroanilino)-7-(5-formyl-3-thienyl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 70. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-(5-formyl-3-thienyl)-3-quinolinecarbonitiile or a pharmaceutically acceptable salt thereof.
- 71. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{5-[(4-methyl-1-piperazinyl) methyl]-3-thienyl}-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 72. The compound according to claim 1, (2 R)-1-((5-[3-Cyano-4-(2,4-dichloro-5-methoxyanilino)-7-quinolinyl]-2-furyl}methyl)-2-pyrrolidinecarboxamide or a pharmaceutically acceptable salt thereof.
- 73. The compound according to claim 1, 7-[5-(4-Morpholinylmethyl)-3-pyridinyl]-4-(4-phenoxyanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 74. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(4-morpholinylmethyl)-3-pyridinyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 75. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 76. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(1,3-dioxolan-2-yl)-2-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 77. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-(5-30 formyl-2-thienyl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 78. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(4-morpholinylmethyl)-2-furyl]-3-quinolinecarbonitiile or a pharmaceutically acceptable salt thereof.
- 79. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[(E)-2-(4-methoxyphenyl) ethenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 80. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{5-[(4-methyl-1 piperazinyl) methyl]-2-thienyl}-3-quinolinecarbonitlile or a pharmaceutically acceptable salt thereof.
- 81. The compound according to claim 1, 7-[5-(4-Morpholinylmethyl)-2-pyridinyl]-4-(4-phenoxyanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 82. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(4-molpholinylmethyl)-2-pyridinyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 83. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-({[2-(phenylsulfonyl) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 84. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-(1H-pyrrol-1-yl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 85. The compound according to claim 1, 4-(3-Bromoanilino)-6-(2-formylpyrrol-1-yl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 86. The compound according to claim 1, 4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-6-(1H-pyrrol-1-yl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 87. The compound according to claim 1, 4-{3-Chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino}-7-(4-formylphenyl)-3-quinolinecarbonitlile or a pharmaceutically acceptable salt thereof.
- 88. The compound according to claim 1, 4-{3-Chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino}-7-[4-(4-moipholinylmethyl) phenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 89. The compound according to claim 1 4-(2,4-Dichloro-5-methoxyanilino)-7-11-[2-(4-morpholinyl) ethyl]imidazol-5-yll}-3 quinolinecarbonitiile or a phaimaceutic ally acceptable salt thereof.
- 90. The compound according to claim 1 4-(2,4-Dichloro-5-methoxyanilino)-7-[4-(4-morph olinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 91. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[2-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 92. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[4-(4-morholinyl) phenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 93. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[4-(4-morpholinylmethyl)-2-thienyl]-3-quinolinecarbon itr ile or a pharmaceutically acceptable salt thereof.
- 94. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-(5-formyl-1-methylpyrrol-2-yl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 95. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[1-methyl-5-(4-morpholinylmethyl)pyrrol-2-yl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 96. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{1-methyl-5-[(4-methyl-1 piperazinyl) methyl]- H-pyrrol-2-yl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 97. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[1-methyl-5-({[2-(phenylsulfonyl) ethyl]amino I methyl)pyrrol-2-yl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 98. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[1-methyl-5-(I{[2-(methyl sulfonyl) ethyl]aminol}methyl)pyrrol-2-yl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 99. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-({[2-(2-pyridinyl) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 100. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-(5-1 [4-(2-hydroxyethyl)-1-piperazin yl]methyl }-2-furyl)-3-quinolinecarbonitril e or a pharmaceutically acceptable salt thereof.
- 101. The compound according to claim 1, 7-(5-{[Bis(2-hydroxyethyl) amino]methyl }-2-furyl)-4-(2,4-dichloro-5-methoxyanilino)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 102. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-({[2-(methylsulfonyl) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 103. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(1-piperidinylmethyl)-2-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 104. The compound according to claim 1, 4-{2-chloro-4-fluoro-5-methoxyanilino)-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonittile or a pharmaceutically acceptable salt thereof.
- 105. The compoundaccording to claim 1, 4-{2-Chloro-5-methoxy-4-methylanilino)-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 106. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[6-(4-molpholinylmethyl)-3-pyridinyl]-3-quninolinecarbonitrileor a pharmaceutically acceptable salt thereof.
- 107. The compound according to claim .1, 7-[4,5-Bis(4-morpholinylmethyl)-2-thienyl]-4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 108. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-(4-formylphenyl)-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 109. The compound according to claim 1, (2R) 1-{4-[3-Cyano-4-(2,4-dichloro-5-methoxyanilino)-7-quinolinyl]benzyl }-2-pyrrolidinecarboxamide or a pharmaceutically acceptable salt thereof.
- 110. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[4-({[2-(phenylsulfonyl) ethyl]amino}methyl) phenyl]-3-quinolinecarbonituile or a pharmaceutically acceptable salt thereof.
- 111. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{4-[(dimethylamino) methyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 112. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{4-[(diethylamino) methyl]phenyl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 113. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[4-({[2-(methylsulfonyl) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 114. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-thienyl}-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 115. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[2-(4-methoxyphenyl) ethynyl]-3-quinolinecarbonithile or a pharmaceutically acceptable salt thereof.
- 116. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-[2-(2-pyridinyl) ethynyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 117. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-pyrrol-1-yl-3-quinolinecarbonitiile or a pharmaceutically acceptable salt thereof.
- 118. The compound according to claim 1, 4-(2,4-Dichloro-5-methoxyanilino)-7-{(2-[(dimethylamino) methyl]pyrrol-1-yl }-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 119. The compound according to claim 1, 7-[5-(1,3-Dioxolan-2-yl)-3-thienyl]-4-[3-methyl-4-(2-pyridinylmethoxy) anilino]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 120. The compound according to claim 1, 4-[3-Methyl-4-(2-pyridinylmethoxy) anilino]-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile or a pharmaceutically acceptable salt thereof.
- 121. A compound of claim 1 which is
4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[4-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(4-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(4-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-{4-[(dimethylamino) methyl]phenyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(4-{[(2-hydroxyethyl) amino]methyl lphenyl)-3-quinolinecarbonitnile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[4-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-f{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino}-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl}phenyl)-3-quinolinecarbonitile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyllanilino I -7-{3-[(4-hydroxy-1-pipenidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilinol}-7-[3-({[2-(dimethylamino) ethyl]amrinol}methyl) phenyl]-3-quinolinecarbonitnile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilinol}-7-(3-{[4-(1-pyrrolidinyl)-l1-pipeiidiyllmethyll}phenyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilinol}-7-(3-1-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanylanilino }-7-13-[(dimetbylamino) methyllphenyl }-3-quinolinecarbonitrie, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[3-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(3-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methyliniidazol-2-yl) sulfanyl]anilino }-7-{3-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl) -3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[3-(1-piperidinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-{3-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyll anilino }-7-(3-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylinidazol-2-yl) sulfanyl]anilino }-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(I-methylimidazol-2-yl) sulfanyl]anilino }-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-(5-{[(2-hydroxyethyl) amino]methyl}-2-thienyl)-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitnile, 4-{3-chloro-4-[(1-methyl-Hl-imidazol-2-yl) sulfanyl]anilino 3-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-pyridinyl]-3-quinolinecarbonitrile, 4-{3-chloro-4-[(1-methylimidazol-2-yl) sulfanyl]anilino }-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-pyridinyl]-3-quinolinecarbonitile, 4-(2,4-dimethylanilino)-7-{4-[(4-hydroxy-1-piperidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 7-[4-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-4-(2,4-dimethylanilino)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(4-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(4-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[4-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[4-(4-morpholinylmethyl) phenyll-3-quinolinecarbonitiile, 4-(2,4-dimethylanilino)-7-(4-{[(2-hydroxyethyl) aamino]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{4-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-20 quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[4-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[4-(1-piperidinylmethyl) phenyl]-3-quinolinecarbonitrile 4-(2,4-dimethylanilino)-7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{3-[(4-hydroxy-1-piperidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 7-[3-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-4-(2,4-dimethylanilino)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(3-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[3-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[3-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(3-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{3-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[3-(1-piperidinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{3-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(3-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 7-[5-({f2-(dimethylamino) ethyl]aminol methyl)-2-furyl]-4-(2,4-dimethylanilino)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[(4-pyridinylmethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-2-furyll-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-(4-morpholinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-methyl- I -piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-(1-piperidinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-thienyl }-3-quinolineearbonitrile, 7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-thienyl]-4-(2,4-dimethylanilino)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[(4-pyridinylmethyl) amino]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-(4-morpholinylmethyl)-2-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-[(2-hydroxyethyl) amino]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-(2 ,4-dimethylanilino)-7-15-[(4-ethyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-hydroxy- -piperidinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-3-thienyl]-4-(2,4-dimethylanilino)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[(4-pyridinylmethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-({[2-(iH-imidazol-4-yl) ethyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[(2-hydroxyethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-methyl- I -piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-[5-(1-piperidinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-(2,4-dimethylanilino)-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyllmethyl }-3-thienyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[(4-pyridinylmethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrie, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-([[2-(iH-imidazol-4-yl) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-(4-morpholinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-(1-piperidinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[(4-pyridinylmethyl) aminolmethyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino Imethyl)-2-thienyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-(4-morpholinylmethyl)-2-thienyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-(5-{[(2-hydroxyethyl) amino]methyl 1-2-thienyl)-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-({[3-(4-morpholinyl) propyl]aamino}-methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-(4-bromo-2-chloro-6-methylanilino)-7-[5-(1-piperidinylmethyl)-2-thienyl]-3-quinolinecarbonitrile, 4-({3-chloro-4′-[(4-hydroxy-1-piperidinyl) methyl]-5-methyl [1,1′-biphenyl]-4-yl }amino)-7-{4-[(4-hydroxy-1-piperidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4′-({[2-(dimethylamino) ethyl]amino}methyl)-5-methyl[1,1′-biphenyl]-4-yl]amino}-7-[4-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-5-methyl-4′-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }[1,1′-biphenyl]-4-yl) amino]-7-(4-f [4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-5-methyl-4′-(4-morpholinylmethyl) [1,1′-biphenyl]-4-yl]amino}-7-[4-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4′- {[(2-hydroxyethyl) aminolmethyl }-5-methyl[1,1′-biphenyl]-4-yl) amino]-7-(4-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-({3-chloro-5-methyl-4′-[(4-methyl-1-piperazinyl) methyl][1,1′-biphenyl]-4-yl }amino)-7-{4-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitnile, 4-{[3-chloro-5-methyl-4′-([{[3-(4-morpholinyl) propyllamino}methyl) [1,1′-biphenyl]-4-yl]amino}-7-[4-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-5-methyl-4′-(1-piperidinylmethyl) [1,1′-biphenyl]-4-yl]amino}-7-[4-(1-piperidinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-({3-chloro-4′-[(4-ethyl-1-piperazinyl) methyl]-5-methyl[1,1′-biphenyl]-4-yl }amino)-7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4′- I [4-(2-hydroxyethyl)-1-piperazinyl]methyl I -5-methyl[1, I-biphenyl]-4-yl) amino]-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl I phenyl)-3-quinolinecarbonitrile, 4-({3-chloro-3′-[(4-hydroxy-1-piperidinyl) methyl]-5-methyl[1,1′-biphenyll-4-yl }amino)-7-{3-[(4-hydroxy-1-pipefidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-3′-({[2-(dimethylamino) ethyl]amino methyl)-5-methyl[l,1′-biphenyl]-4-yl]amino}-7-[3-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-5-methyl-3′- {[4-(1-pyrrolidinyl)-1-pipefidinyllmethyl }[1,1′-biphenyl]-4-yl) amino]-7-(3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-[(3-chloro-5-methyl-3′- {[(4-pyridinylmethyl) amino]methyl }[1,1′-biphenyl]-4-10 yl) amino]-7-(3-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-3′-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-5-methyl[1,1′-biphenyl]-4-yl) amino}-7-[3-({[2-(1H-imidazol-4-yl) ethyl) amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-5-methyl-3′-(4-morpholinylmethyl) [,1′-biphenyl]-4-yl]amino -7-[3-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-3′- {[(2-hydroxyethyl) amino]methyl }-5-methyl[1,1′-biphenyl]-4-20 yl) amino]-7-(3-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-({3-chloro-5-methyl-3′-[(4-methyl-1-piperazinyl) methyl) [1,1′-biphenyl]-4-yl }amino)-7-{3-[(4-methyl- I -piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-5-methyl-3′-({[3-(4-morpholinyl) propyll amino}methyl) [1,1′-biphenyl]-4-yl]amino}-7-[3-({[3-(4-morpholinyl) propyl amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-5-methyl-3′-(1-piperidinylmethyl) [1,1′-biphenyl]-4-yl]amino}-7-[3-(1-30 piperidinylmethyl) phenyll-3-quinolinecarbonitrile, 4-({3-chloro-3′-[(4-ethyl-1-piperazinyl) methyll-5-methyl [1,1′-biphenyll-4-yl I amino)-7-{3-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-[(3-chloro-3′-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-5-methyl 1,1′-biphenyll-4-yl) amino]-7-(3-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{2-chloro-4-[5-({[2-(dimethylamino) ethyl]amino lmethyl)-3-thienyl]-6-methyl anilino }-7-[5-({[2-(dimethylamino) ethyl]lamino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-[2-chloro-6-methyl-4-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-3-thienyl) anilino]-7-(S- {[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-[2-chloro-6-methyl-4-(5-{[(4-pyridinylmethyl) aminolmethyl I -3-thienyl) anilinol-7-(5-t [(4-pyridinylmethyl) amino]methyl 1-3-thienyl)-3-quinolinecarbonitrile, 4-{2-chloro-4-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-3-thienyl]-6-methylanilino }-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-12-chloro-6-methyl-4-[5-(4-morpholinylmethyl)-3-thienyl]anilino 1-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2-chloro-6-methyl-4-{5-[(4-methyl-1-piperazinyl) methyl]-3-thienyl }anilino)-7-{5-[(4-methyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-{2-chloro-6-methyl-4-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-3-thienyl]anilino }-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{2-chloro-6-methyl-4-[5-(1-piperidinylmethyl)-3-thienyl]anilino }-7-[5-(1-piperidinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2-chloro-4-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-6-methylanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-[2-chloro-4-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-3-thienyl)-6-methylanilino]-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[4-({[3-(4-morpholinyl) propyl]amino}-methyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino)-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[3-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(3-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{3-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[2-(dimethylamino) ethyl]amiino }methyl)-2-furyl]-3-quinolinecarbonitrie, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[(4-pyridinylmethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-(4-morpholinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[3-(4-5 morpholinyl) propyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-(1-piperidinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) antino]-7-(5-1 [4-(1-pyrrolidinyl)-1-20 piperidinyl]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[(4-pyridinylmethyl) amino]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro4-phenoxyphenyl) amino]-7-[5-(4-morpholinylmethyl)-2-thienyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) aminol-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-hydroxy-1-pipelidinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[(4-pyridinylmethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[(2-hydroxyethyl) amino) methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-methyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-(1-piperidinylmethyl)-3-thienyl1-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-[(3-chloro-4-phenoxyphenyl) amino]-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-pyridinyl]-3-quinolinecarbonitrile, 4-1 [3-chloro-4-(phenylsulfanyl) phenyl aminol-7-1 4-[(4-hydroxy-l1-piperidinyl) methyllphenyl I -3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(4-1 [(4-pyridinylmethyl) amino]methyl lphenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[4-(I{[2-(l1H-imidazol-4-yl) ethyl]amino I methyl) phenyll-3-quinolinecarbonitrie, 4-1-{[3-chloro4-(phenylsulfanyl) phenyl]amino) }-7-[4-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(4-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[4-[(4-methyl-1-piperazinyl) methyllphenyl) -3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[4-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{3-[(4-hydroxy-1-piperidinyl) methyllphenyl -3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[3-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(3-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(3-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(5-{[(4-pyridinylmethyl) aminolmethyl }-2-furyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[2-(1H-imidazol-4-yl) ethyl]aamino lmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-(4-morpholinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]aamino}-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-(4-morpholinylmethyl)-2-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-methyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-thienyl]-3-quinolinec arbonitri le, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[2-(dimethylamino) ethyl]amino Imethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(5-{[(4-pyridinylmethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyll amino}-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino 1-7-(5-{[(2-hydroxyethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-methyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-[5-(1-piperidinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(phenylsulfanyl) phenyl]amino}-7-(5-1 [4-(2-hydroxyethyl)-1-piperazinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-{4-[(4-hydroxy-1-piperidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]lamino}-7-[4-({[2-(dimethylamino) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-(4-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-(4-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-[4-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-[4-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-(4-{[(2-hydroxyethyl) amino]methyl}phenyl)-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-{4-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-[4-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-[4-(1-piperidinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyl]amino}-7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[3-chloro-4-(3-furylmethyl) phenyllamino}-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(4-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[4-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[4-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(4-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-{4-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]aamino}-7-[4-(1-piperidinylmethyl) phenyl]-3-quinolinecarbonitrile, 7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-4-{[4-(3-furylmethyl) phenyl]amino}-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(4-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-{3-[(4-hydroxy-1-piperidinyl) methyl]phenyl }-3-quinolinecarbonitrile, 7-[3-({[2-(dimethylamino) ethyl]amino}methyl) phenyll-4-{[4-(3-furylmethyl) phenyl]amino}-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(3-{[(4-pyridinylmethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[3-({[2-(1H-imidazol-4-yl) ethyl]aamino}methyl) phenyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[3-(4-morpholinylmethyl) phenyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(3-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-{3-[(4-methyl-1-piperazinyl) methyl]phenyl }-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 7-{3-[(4-ethyl-1-piperazinyl) methyl]phenyl }-4-{[4-(3-furylmethyl) phenyl]amtino }-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(3-{[4-(2-hydroxyethyl)-1-piperazinyllmethyl }phenyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-pyridinyl }-3-quinolinecarbonitrile, 7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-pyridinyl]-4-{[4-(3-furylmethyl) phenyl]amino}-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-pyridinyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[5-({[3-(4-mofpholinyl) propyl]amino}methyl)-2-pyridinyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino I -7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-2-pyridinyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-3-thienyl }-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-3-thienyt)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(5-{[(4-pyridinylmethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[5-(4-morpholinylmethyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(5-{[(2-hydroxyethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino I -7-{5-[(4-methyl-1-piperazinyl) methyl]-3-thienyl }-3-quinolinecarbonittile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-[5-(1-piperidinylmethyl)-3-thienyll-3-quinolinecarbonitrile, 7-{5-[(4-ethyl-1-piperazinyl) methyl]-3-thienyl }-4-{[4-(3-furylmethyl) phenyl]amino}-3-quinolinecarbonitrile, 4-{[4-(3-furylmethyl) phenyl]amino}-7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-3-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(4-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(4-{[(4-pyridinylmethyl) amino]methyl}phenyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[4-({[2-(1H-imidazol-4-yl) ethyl]namino}methyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(4-{[(2-hydroxyethyl) amino]methyl }phenyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[4-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[(4-pyridinylmethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[(2-hydroxyethyl) amino]methyl }-2-furyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-furyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-(1-piperidinylmethyl)-2-furyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-furyl }-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyll methyl }-2-thienyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-thienyl }-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-3-thienyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[(4-pyridinylmethyl) amino]methyl }-3-thienyl)-3-quinolinecarbonitlile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-3-thienyll-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-pyridinyl }-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[2-(dimethylamino) ethyl]amino}methyl)-2-pyridinyll-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }-2-pyridinyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-(5-{[(2-hydroxyethyl) amino]methyl}-2-pyridinyl)-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[5-({[3-(4-morpholinyl) propyl]amino}methyl)-2-pyridinyl]-3-quinolinecarbonitrile, 4-(2,4-dichloro-5-methoxyanilino)-7-[(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl)-2-pyridinyl]-3-quinolinecarbonitrile, 7-{4-[(4-hydroxy-1-piperidinyl) methyl]phenyl }-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[4-(4-morpholinylmethyl) phenyl]-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(4-{[(2-hydroxyethyl) amino]methyl }phenyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{4-[(4-methyl-1-piperazinyl) methyl]phenyl }-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[4-(1-piperidinylmethyl) phenyl]-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{4-[(4-ethyl-1-piperazinyl) methyl]phenyl }-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{3-[(4-hydroxy- I -piperidinyl) methyl]phenyl }-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[3-(I [2-(dimethylamino) ethyl]amino}methyl) phenyl]-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl }phenyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(3-{[(4-pyridinylmethyl) aminolmethyl }phenyl) 4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[3-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl) phenyl]-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[3-(4-morpholinylmethyl) phenyl]-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(3-{[(2-hydroxyethyl) amino]methyl }phenyl)-4-(3,4,5-trimethoxyanilino-3-quinolinecarbonitrile, 7-{3-[(4-methyl-1-piperazinyl) methyl]phenyl }-4-(3,4,5-trimethoxyanilino)-3-5 quinolinecarbonitrile, 7-[3-({[3-(4-morpholinyl) propyl]amino}methyl) phenyl]-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[3-(1-piperidinylmethyl) phenyl]-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-((3-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }phenyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(5-{1 [4-(1-pyrrolidinyl)-1-piperidinyllmethyl }-2-furyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{5-[(4-hydroxy-1-piperidinyl) methyll-2-thienyl }-4-(3,4,5-trimethoxyanilino)-3-20 quinolinecarbonitrile, 7-[5-({[2-(1H-imidazol-4-yl) ethyl]amino}methyl)-2-thienyl]-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{5-[(4-methyl-1-piperazinyl) methyll -2-thienyl }-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{5-[(4-ethyl-1-piperazinyl) methyl]-2-thienyl }-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl }-2-thienyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(5-{[(4-pyridinylmethyl) aminolmethyl }-3-thienyl)-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[5-(4-morpholinylmethyl)-3-thienyl]-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(5-{[(2-hydroxyethyl) amino]methyl }-3-thienyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-5-[(4-methyl-1-piperazinyl) methy]-3-thienyll-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-{5-[(4-hydroxy-1-piperidinyl) methyl]-2-pyridinyl }-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-(5-1-{[4-(I1-pyrrolidinyl)-l1-pipeiidinyllmethyl) }-2-pyridinyl)-4-(3 ,4,5-trimethoxyarniino)-3-quinolinecarborntrie, 7-(5 {-[(2-hydroxyeth1)amino]nmethyl }-2-pyridinyl)-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile, 7-[5-({[3-(4-mopholinyl) propyllaniinol}methyl)-2-pyridinyl]-4-(3 ,4,5-trimethoxyanilino)-3-quinolinecarbonitrile or 7-[(5-{[4-(2-hydroxyethyl)-1-piperazinyl]methyl)-2-pyridinyl]-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile and pharmaceutically acceptable salts thereof.
- 122. A method of treating, inhibiting the growth of, or eradicating neoplasms in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) having the structure:
- 123. The method according to claim 122 wherein the neoplasm is selected from the group consisting of breast, kidney, bladder, mouth, larynx, esophagus, stomach, colon, ovary, lung, pancreas, skin, liver, prostate and brain.
- 124. The method of claim 122 wherein the neoplasm expresses Src or wherein the neoplasm depends at least in part on the Src pathway.
- 125. The method of claim 122 wherein the neoplasm expresses raf or wherein the neoplasm depends at least in part on the raf pathway.
- 126. The method of claim 122 wherein the neoplasm expresses EGFr, erbB-2, erbB-3 or erbB-4 or wherein the neoplasm depends at least in part on an EGFr, erbB-2, erbB-3 or erbB-4 pathway.
- 127. The method of claim 122 wherein the neoplasm expresses KDR or flt-i or wherein the neoplasm depends at least in part on a KDR or flt-I pathway.
- 128. The method of claim 122 wherein the neoplasm expresses PDGFr or wherein the neoplasm depends at least in part on the PDGFr pathway.
- 129. The method of claim 122 wherein the neoplasm expresses FGFr or wherein the neoplasm depends at least in part on the FGFr pathway.
- 130. The method of claim 122 wherein the neoplasm expresses tie-1 or tie-2 or wherein the neoplasm depends at least in part on a tie-1 or tie-2 pathway.
- 131. The method of claim 122 wherein the neoplasm expresses EPH or wherein the neoplasm depends at least in part on the EPH pathway.
- 132. The method of claim 122 wherein the neoplasm expresses a non-receptor tyrosine kinase including Abl, Jak, Fak, Syk or Csk or wherein the neoplasm depends at least in part on a Abl, Jak, Fak, Syk or Csk pathway.
- 133. The method of claim 122 wherein the neoplasm expresses mek or erk or wherein the neoplasm depends at least in part on the MAPK pathway.
- 134. The method of claim 122 wherein the neoplasm expresses a cyclin dependent kinase or wherein the neoplasm depends at least in part on a cyclin dependent kinase pathway.
- 135. The method of claim 122 wherein the neoplasm expresses a Src family kinase including Yes, Lck or Lyn or wherein the neoplasm depends at least in part on a Src family kinase pathway.
- 136. The method of claim 122 wherein the neoplasm expresses PKA, PKB or PKC or wherein the neoplasm depends at least in part on a PKA, PKB or PKC pathway.
- 137. A method of treating, inhibiting the progression of, or eradicating polycystic kidney disease in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of Formula (I) having the structure:
- 138. A method of treating, inhibiting, or eradicating colonic poly
- 139. A method of treating a disease or inhibiting a disease state whose etiology is at least in part caused by a defect in a signaling pathway upstream from a protein kinase; by overexpression of a protein kinase; or by a dysregulated protein kinase in a mammal in need thereof which comprises providing said mammal an effective amount of a compound of Formula (I),
- 140. A method of inhibiting the biological effects of a deregulated protein kinase in a mammal which comprises administering to said mammal an effective amount of a compound of Formula (I)
- 141. A pharmaceutical composition for treating or inhibiting disease in a mammal characterized by abnormal growth of cells which comprises administering to a mammal in need thereof an effective amount of a compound of Formula (I) having the structure:
- 142. A method of treating or inhibiting the progression of restenosis in a mammal in need thereof which comprises providing to said mammal an effective amount of a PDGFr kinase inhibitor of Formula (I), having the structure
- 143. A method of treating, inhibiting or eradicating autoimmune diseases which include rheumatoid arthritis, sepsis and transplant rejection in a mammal in need thereof which comprises providing to said mammal an effective amount of a Zap-70 or Lck kinase inhibitor of Formula (I), having the structure
- 144. A method of treating, inhibiting or eradicating viral infections in a mammal in need thereof which comprises providing to said mammal an effective amount of a UL-97 kinase inhibitor of Formula (I), having the structure
- 145. A method of treating or inhibiting the progression of osteoporosis in a mammal in need thereof which comprises providing to said mammal an effective amount of a Src kinase inhibitor of Formula (I), having the structure
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims benefit of U.S. Provisional Application No. 60/219,322 which was converted from U.S. patent application Ser. No. 09/535,843 filed Mar. 28, 2000 pursuant to a petition filed under 37 C.F.R. 1.53 (c) (2 ) filed Aug. 2, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60219322 |
Mar 2000 |
US |
Patent Application
20020026052
