Claims
- 1. A compound of the formula: ##STR5## wherein R is hydrogen, alkyl of from 1 to 5 carbon atoms, or unsaturated alkyl of from 2 to 5 carbon atoms and n is 4, 5, or 6.
- 2. A compound according to claim 1 wherein R contains 1 to 3 carbon atoms.
- 3. A compound according to claim 2 wherein R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, allyl and propynyl.
- 4. A compound according to claim 1 wherein n is 4.
- 5. The compound of claim 4 which is 3-Oxo-2-azaspiro[4,4]nonane-acetamide.
- 6. The compound of claim 4 which is 3-Oxo-2-azaspiro[4,4]nonane-2-(N-methyl)-acetamide.
- 7. A compound according to claim 1 wherein n is 5.
- 8. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-acetamide.
- 9. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-(N-methyl)-acetamide.
- 10. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-(N-allyl)-acetamide.
- 11. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-(N-2-propynyl)-acetamide.
- 12. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-(N-n-pentyl)-acetamide.
- 13. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-(N-isopropyl)-acetamide.
- 14. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-(N-ethyl)-acetamide.
- 15. The compound of claim 7 which is 3-Oxo-2-azaspiro[4,5]decane-2-(N-2-methylallyl)-acetamide.
- 16. A compound according to claim 1 wherein n is 6.
- 17. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-acetamide.
- 18. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-(N-methyl)-acetamide.
- 19. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-(N-allyl)-acetamide.
- 20. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-(N-2-propynyl)-acetamide.
- 21. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-(N-2-methylallyl)-acetamide.
- 22. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-(N-ethyl)-acetamide.
- 23. The compound of claim 16 which is 3-Oxo-2-azaspiro[4,6]undecane-2-(N-butyl)-acetamide.
- 24. A pharmaceutical composition useful for the treatment of convulsions which comprises an anti-convulsive effective amount of at least one compound of the formula: ##STR6## wherein R is hydrogen, alkyl of from 1 to 5 carbon atoms or unsaturated alkyl of from 2 to 5 carbon atoms and n is 4, 5 or 6 in admixture with a solid or liquid pharmaceutical diluent or carrier.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2557220 |
Dec 1975 |
DEX |
|
Parent Case Info
This is a continuation of Ser. No. 746,776, filed Dec. 2, 1976, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
2935515 |
Larrabee |
May 1960 |
|
Non-Patent Literature Citations (1)
Entry |
Burger, A. "Medicinal Chemistry," 2nd ed., Interscience Publishers Inc., N.Y., 1960, p. 491. |
Continuations (1)
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Number |
Date |
Country |
Parent |
746776 |
Dec 1976 |
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