Claims
- 1. Process for the preparation of a 3-phenyl-2-propeneamine of the formula: ##STR35## in which R denotes hydrogen, halogen, alkyl, alkyloxy, alkylthio, amino, alkylamino, dialkylamino or trifluoromethyl;
- R.sub.3 denotes hydrogen or alkyl;
- either R.sub.4 and R.sub.5 each denote hydrogen and R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen or alkyl which is unsubstituted or substituted by alkenyl of 2 to 4 carbon atoms, R.sub.1 and R.sub.2 not simultaneously denoting hydrogen, or R.sub.1 and R.sub.2 form together with the nitrogen atom to which they are linked denote a saturated heterocyclic radical of 4 to 7 ring atoms optionally containing another heteroatom such as oxygen, sulphur or nitrogen which is unsubstituted or substituted by alkyl;
- or R.sub.4 denotes hydrogen, R.sub.1 denotes hydrogen or alkyl and R.sub.2 and R.sub.5 together form an alkylene radical of 3 or 4 carbon atoms;
- and A denotes alkyl or phenyl which is unsubstituted or substituted by one or two substituents chosen from halogen, alkyl, alkyloxy, alkylthio, amino, alkylamino, dialkylamino, nitro and trifluoromethyl or A denotes pyridyl, benzyl or cycloalkyl of 3 to 6 carbon atoms; and
- R.sub.6 denotes hydrogen or alkyl, the aforesaid alkyl radicals and alkyl parts containing 1 to 4 carbon atoms each as a straight or branched chain, in the Z-configuration;
- which comprises reacting a compound of formula:
- A--CO--R.sub.6 (III)
- in which A and R.sub.6 are as defined above, with a carbanion of formula: ##STR36## in which the symbols are as defined above, and isolating the product obtained and optionally converting it into a pharmaceutically acceptable salt.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8402338 |
Feb 1984 |
FRX |
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Parent Case Info
This is a division of application Ser. No. 702,088 filed Feb. 15, 1985, now U.S. Pat. No. 4,686,309.
US Referenced Citations (3)
Non-Patent Literature Citations (1)
Entry |
Sundberg, R. J. et al. J. of Organic Chemistry, vol. 46, No. 18, (1981), pp. 3730-3732. |
Divisions (1)
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Number |
Date |
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Parent |
702088 |
Feb 1985 |
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