Claims
- 1. A compound of formula: ##STR13##
- where A is 1. pyridyl, either unsubstituted or substituted with lower alkyl,
- 2. lower cycloalkyl, ##STR14## wherein R.sup.1 and R.sup.2 are the same or different and each is a. hydrogen,
- b. lower alkoxy,
- c. lower alkyl,
- d. halo,
- e. trifluoromethyl,
- f. amino, either unsubstituted or substituted with lower alkyl,
- g. phenoxy,
- h. hydroxy,
- i. lower alkanoyl,
- or R.sup.1 and R.sup.2 on adjacent carbon atoms taken together represent --(CH.sub.2).sub.3 --,
- R.sup.3 is
- a. hydrogen,
- b. lower alkoxy, or
- c. lower alkyl,
- R.sup.4 is
- 1. hydrogen or
- 2. lower alkyl.
- 2. The compound of claim 1 of formula: ##STR15## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen or fluoro.
- 3. The compound of claim 1 of formula: ##STR16## wherein A is pyridyl or lower alkylpyridyl.
- 4. A method of treating pain, inflammation or fever which comprises the administration to a patient in need of such treatment an effective amount of a compound of formula: ##STR17##
- where A is 1. pyridyl, either unsubstituted or substituted with lower alkyl,
- 2. lower cycloalkyl,
- 3. ##STR18## wherein R.sup.1 and R.sup.2 are the same or different and each is a. hydrogen,
- b. lower alkoxy,
- c. lower alkyl,
- d. halo,
- e. trifluoromethyl,
- f. amino, either unsubstituted or substituted with lower alkyl,
- g. phenoxy,
- h. hydroxy,
- i. lower alkanoyl,
- or R.sup.1 and R.sup.2 on adjacent carbon atoms taken together represent --(CH.sub.2).sub.3 --,
- R.sup.3 is
- a. hydrogen,
- b. lower alkoxy, or
- c. lower alkyl,
- R.sup.4 is
- 1. hydrogen or
- 2. lower alkyl.
- 5. A pharmaceutical composition for treating pain, inflammation or fever comprising an inert carrier and an effective amount of a compound of formula: ##STR19##
- where A is 1. pyridyl, either unsubstituted or substituted with lower alkyl,
- 2. lower cycloalkyl, ##STR20## wherein R.sup.1 and R.sup.2 are the same or different and each is a. hydrogen,
- b. lower alkoxy,
- c. lower alkyl,
- d. halo,
- e. trifluoromethyl,
- f. amino, either unsubstituted or substituted with lower alkyl,
- g. phenoxy,
- h. hydroxy,
- i. lower alkanoyl,
- or R.sup.1 and R.sup.2 on adjacent carbon atoms taken together represent --(CH.sub.2).sub.3 --,
- R.sup.3 is
- a. hydrogen,
- b. lower alkoxy, or
- c. lower alkyl,
- R.sup.4 is
- 1. hydrogen or
- 2. lower alkyl.
Parent Case Info
This application is a continuation-in-part of our application Ser. No. 601,671, filed May 28, 1975 now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
1,268,772 |
Mar 1972 |
UK |
Non-Patent Literature Citations (3)
Entry |
Vohra et al. "J. Med. Chem." vol. 8 (1965) pp. 296-304. |
Ahmad et al. "Chem. Abstracts" vol. 68 (1968) No. 94537j. |
Ahmad "Chem. Abstracts" vol. 70 (1969) No. 45865x. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
601671 |
May 1975 |
|