Claims
- 1. A compound of the formula ##STR3## wherein: R.sub.1 is C.sub.1 alkyl-S--, CF.sub.3 S--, CF.sub.3 O--, H.sub.2 NCO--, H.sub.2 NSO.sub.2 --, or CH.sub.3 SO.sub.2 NH--;
- R.sub.2 is hydrogen or methyl; or
- the pharmaceutically acceptable acid addition salts thereof,
- provided that when the compound is a pharmaceutically acceptable acid addition salt of C.sub.1 alkyl-S--; the salt must be hydrochloride, oxalate, maleate, or fumarate.
- 2. A compound of claim 1 wherein R.sub.2 is hydrogen.
- 3. A compound of claim 1 wherein R.sub.2 is methyl.
- 4. A compound of claim 2 which is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 5. A compound of claim 3 which is N,N-dimethyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 6. A method for inhibiting serotonin uptake in mammals which comprises administering to a mammal requiring increased neurotransmission of serotonin an effective amount of a compound of claim 1.
- 7. A method of claim 6 employing a compound wherein R.sub.2 is hydrogen.
- 8. A method of claim 7 wherein the compound is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 9. A method of treating depression in humans comprising administering to a human suffering from depression an effective antidepressant dose of a compound of claim 1.
- 10. A method claim 9 employing a compound wherein R.sub.2 is hydrogen.
- 11. A method of claim 10 wherein the compound is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 12. A method of treating obesity in humans comprising administering to a human suffering from obesity an effective antiobesity dose of a compound of claim 1.
- 13. A method of claim 12 employing a compound wherein R.sub.2 is hydrogen.
- 14. A method of claim 13 wherein the compound is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 15. A method of suppressing the desire of humans to smoke comprising administering to a human in need of such suppression an effective dose to relieve the desire to smoke of a compound of claim 1.
- 16. A method of claim 15 employing a compound wherein R.sub.2 is hydrogen.
- 17. A method of claim 16 wherein the compound is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 18. A method of suppressing the desire of humans to consume alcohol comprising administering to a human in need of such suppression an effective dose to relieve the desire to consume alcohol of a compound of claim 1.
- 19. A method of claim 18 employing a compound wherein R.sub.2 is hydrogen.
- 20. A method of claim 19 wherein the compound is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
- 21. A pharmaceutical formulation comprising a compound of claim 1 and a pharmaceutically acceptable carrier, a diluent or excipient therefor.
- 22. A formulation of claim 21 employing a compound wherein R.sub.2 is hydrogen.
- 23. A formulation of claim 22 wherein the compound is N-methyl-.gamma.-[4-(methylthio)phenoxy]benzenepropanamine hydrochloride.
Parent Case Info
This application is a continuation of application Ser. No. 07/617,467, filed on Nov. 20, 1990, now abandoned; which in turn is a continuation of application Ser. No. 07/179,368, filed on Apr. 8, 1988, now abandoned.
US Referenced Citations (11)
Foreign Referenced Citations (3)
Number |
Date |
Country |
0178874 |
Apr 1986 |
EPX |
2026487 |
Feb 1980 |
GBX |
1585036 |
Feb 1981 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Wolff; in "Burger's Medicinal Chemistry"; Part III; 4th Ed.; p. 1043: 1979. |
Continuations (2)
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Number |
Date |
Country |
Parent |
617467 |
Nov 1990 |
|
Parent |
179368 |
Apr 1988 |
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