Claims
- 1. A compound of the formula: ##STR4## wherein R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a saturated 5-, 6- or 7-membered heterocyclic ring which can also contain a further nitrogen atom or an oxygen or sulphur atom, A is a straight-chain or branched hydrocarbon chain containing 2 to 4 carbon atoms and R.sub.3 is a saturated or unsaturated, straight-chain or branched aliphatic hydrocarbon radical containing up to 6 carbon atoms or is the radical --Alk--Ar, wherein Alk is an alkylene chain containing up to 3 carbon atoms and Ar is a phenyl or heteroaryl radical optionally substituted by halogen atoms and/or lower alkoxy radicals; and the pharmacologically compatible salts thereof.
- 2. A compound according to claim 1, wherein R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached, represent a piperidino, morpholino, piperazino or N.sub.4 '-methylpiperazino radical, A is an ethylene or propylene chain and R.sub.3 is a saturated or unsaturated aliphatic hydrocarbon radical containing up to 4 carbon atoms, Alk is a methylene, ethylene or ethylidene chain and Ar is a phenyl, pyridyl or furyl ring optionally substituted by a chlorine atom or a methoxy radical.
- 3. The compound according to claim 1 which is 1-Benzyl-3-(.beta.-N-morpholinoethoxy)-4-phenyl-3-pyrrolin-2-one.
- 4. The compound according to claim 1 which is 1-n-Butyl-3-[N.sub.1 -.beta.-(N.sub.4 -methyl)-piperazinoethoxy]-4-phenyl-3-pyrrolin-2-one.
- 5. The compound according to claim 1 which is 1-Ethyl-3-(.beta.-piperidinoethoxy)-4-phenyl-3-pyrrolin-2-one.
- 6. The compound according to claim 1 which is 1-(4'-Methoxybenzyl)-3-[N.sub.1 -.beta.-(N.sub.4 -methyl)-piperazino-ethoxy]-4-phenyl-3-pyrrolin-2-one.
- 7. The compound according to claim 1 which is 1-Methyl-3-[N.sub.1 -.beta.-(N.sub.4 -methyl)-piperazinoethoxy]-4-phenyl-3-pyrrolin-2-one.
- 8. A pharmaceutical composition comprising an antihypertensive effective amount of at least one compound according to claim 1, in admixture with a solid or liquid pharmaceutical diluent or carrier.
Priority Claims (1)
Number |
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2636723 |
Aug 1976 |
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Parent Case Info
This is a divisional of U.S. Ser. No. 922,018, filed July 5, 1978, now U.S. Pat. No. 4,205,078, which is a continuation of U.S. Ser. No. 821,259, filed Aug. 3, 1977, which is now abandoned.
Non-Patent Literature Citations (1)
Entry |
Kurkovskaya et al., "Chem. Abstracts " vol. 83 (1975) No. 96135k. |
Divisions (1)
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922018 |
Jul 1978 |
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Continuations (1)
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821259 |
Aug 1977 |
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