Claims
- 1. A compound of the formula ##STR20## wherein R.sup.1 is hydrogen or a conventional amino-protecting group,
- R.sup.2 is hydrogen, or alkanoyl having 2 to 4 carbon atoms,
- R.sup.3 is hydrogen or lower alkanoyloxy having 2 to 3 carbon atoms, and when R.sup.2 and R.sup.3 are each hydrogen, R.sup.4 is also hydrogen, and
- R.sup.4 is hydrogen, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl, 1-(ethoxycarbonyloxy)ethyl, 1-(pivaloyloxy)ethyl, 1-(cyclohexylacetoxy)ethyl, or 1-(cyclohexyloxycarbonyloxy)ethyl.
- 2. The compound of claim 1 which is 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(Z)-prop-1-en-1-yl]-3-cephem-4-carboxylic acid.
- 3. The compound of claim 1 which is 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-](E)-prop-1-en-1-yl]-3-cephem-4-carboxylic acid.
- 4. The compound of claim 1 wherein R.sup.4 is (5-methyl-2-oxo--1,3-dioxolen-4-yl)methyl.
- 5. The compound of claim 4 (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(Z)-prop-1-en-1-yl]-3-cephem-4-carboxylate.
- 6. The compound of claim 1 wherein R.sup.4 is 1-(ethoxycarbonyloxy)ethyl.
- 7. The compound of claim 6, 1-(ethoxycarbonyloxy)ethyl 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(Z)-prop-1-en-1-yl]-3-cephem-4-carboxylate.
- 8. The compound of claim 1 where in R.sup.4 is 1-(pivaloyloxy)ethyl.
- 9. The compound of claim 8, 1-(pivaloyloxy)ethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(Z)-1-propenyl]-3-cephem-4-carboxylate.
- 10. The compound of claim 1 wherein R.sup.4 is 1-(cyclohexylacetoxy)ethyl.
- 11. The compound of claim 10, 1-(cyclohexylacetoxy)ethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(Z)-1-propenyl]-3-cephem-4-carboxylate.
- 12. The compound of claim 1 wherein R.sup.4 is 1-cyclohexyloxycarbonyloxy)ethyl.
- 13. The compound of claim 12, 1-(cyclohexyloxycarbonyloxy)ethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(Z)-1-propenyl]-3-cephem-4-carboxylate.
REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of Ser. No. 882,110 filed July 3, 1986 and now abandoned, which is in turn a continuation-in-part of co-pending application Ser. No. 748,359 filed June 24, 1985, now U.S. Pat. No. 4,708,955 patented Nov. 24, 1987. The specifications of those applications are incorporated herein by reference.
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
882110 |
Jul 1986 |
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Parent |
748359 |
Jun 1985 |
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